Basic information Safety Supplier Related

Nicaraven

Basic information Safety Supplier Related

Nicaraven Basic information

Product Name:
Nicaraven
Synonyms:
  • n,n'-propylenedinicotinamide
  • NICARAVEN
  • 1,2-bis(nicotinamido)propane
  • AVS
  • N,N'-(1-Methylethylene)bis(pyridine-3-carboxamide)
  • N,N'-(1-Methylethylene)bisnicotinamide
  • N,N'-Propylenebis(nicotinamide)
  • N,N'-Propylenebisnicotinamide
CAS:
79455-30-4
MF:
C15H16N4O2
MW:
284.31
EINECS:
1806241-263-5
Product Categories:
  • Inhibitors
Mol File:
79455-30-4.mol
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Nicaraven Chemical Properties

Melting point:
156-157°
Boiling point:
635.9±40.0 °C(Predicted)
Density 
1.213±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMF: 5 mg/ml; DMSO: 10 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): 2 mg/ml
form 
A crystalline solid
pka
12.93±0.46(Predicted)
color 
White to off-white
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Nicaraven Usage And Synthesis

Description

Nicaraven is an antioxidant that exhibits hydroxyl radical scavenging activity in vitro. Nicaraven (1-3 mg/kg per min, i.v.) reduces occurrence of chronic cerebral vasospasms in a dose-dependent manner in a canine model of subarachnoid hemorrhage. In a canine model of warm hepatic ischemia and reperfusion injury, nicaraven (2 mg/kg per min, i.v.) reduces liver enzyme release and inhibits lipid peroxidation and neutrophil infiltration in the liver. Nicaraven (100 mg/kg per day, i.p.) also decreases plasma levels of the inflammatory cytokines Il-6 and Tnf-α and the urinary levels of 8-oxo-2''-deoxyguanosine, a marker of DNA oxidation, in a mouse model of radiation-induced injury.

Uses

Nicaraven is a novel chemically synthesized hydroxyl radical-specific scavenger.

in vivo

Nicaraven inhibits lipid peroxidation in the liver, improves hepatic and systemic hemodynamics and energy metabolism, and suppresses liver enzyme release, endothelin-1 elevation in hepatic venous blood, histologic damage, and neutrophil infiltration into the liver[1]. Nicaraven increases the number of c-kit(+) stem/progenitor cells in bone marrow and peripheral blood, with a recovery rate around 60-90% of age-matched non-irradiated healthy mice. The potency of colony forming from hematopoietic stem/progenitor cells as indicator of function is completely protected with nicaraven treatment[2]. Administration of nicaraven significantly increases the number, improves the colony-forming capacity, and decreases the DNA damage of hematopoietic stem/progenitor cells. The urinary levels of 8-oxo-2′-deoxyguanosine, a marker of DNA oxidation, are significantly lower in mice that are given nicaraven compared with those that receive a placebo. The administration of nicaraven significantly decreases the levels of the inflammatory cytokines IL-6 and TNF-α in the plasma of mice[3].

References

[1] Komiya T, et al. A novel free radical scavenger, nicaraven, inhibits human platelet aggregation in vitro. Clin Neuropharmacol. 1999 Jan-Feb;22(1):11-4. DOI:10.1097/00002826-199901000-00003
[2] Yokota R, et al. A novel hydroxyl radical scavenger, nicaraven, protects the liver from warm ischemia and reperfusion injury. Surgery. 2000 Jun;127(6):661-9. DOI:10.1067/msy.2000.105864
[3] Ali H, et al. The potential benefits of nicaraven to protect against radiation-induced injury in hematopoietic stem/progenitor cells with relative low dose exposures. DOI:10.1016/j.bbrc.2014.08.112
[4] Nicaraven attenuates radiation-induced injury in hematopoietic stem/progenitor cells in mice. PLoS One. 2013;8(3):e60023. DOI:10.1371/journal.pone.0060023

NicaravenSupplier

nanjing Gold
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+86-21-20908456
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Dalian Meilun Biotech Co., Ltd.
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Shanghai T&W Pharmaceutical Co., Ltd.
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+86 21 61551611
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