2-Methoxyethyl acetate Chemical Properties

Melting point:

−65 °C(lit.)

Boiling point:

145 °C(lit.)

Density 

1.009 g/mL at 25 °C(lit.)

vapor pressure 

4.7 hPa (20 °C)

refractive index 

n20/D 1.402(lit.)

Flash point:

111 °F

storage temp. 

Store below +30°C.

solubility 

Soluble in alcohol and ether (Weast, 1986).

form 

Solid

color 

White

explosive limit

1.7-8.8%(V)

Water Solubility 

Miscible (Lyman et al., 1982)

λmax

λ: 254 nm Amax: 1.00
λ: 275 nm Amax: 0.15
λ: 300 nm Amax: 0.05
λ: 350-400 nm Amax: 0.01

Merck 

14,6039

BRN 

1700761

Henry's Law Constant

(x 10^-6 atm?m³/mol): 3.28 at 30.00 °C (headspace-GC, Hovorka et al., 2002)

Exposure limits

NIOSH REL: TWA 0.1 ppm (0.5 mg/m³), IDLH 200 ppm; OSHA PEL: TWA 25 ppm (120 mg/m³); ACGIH TLV: TWA 5 ppm (24 mg/m³).

CAS DataBase Reference

110-49-6(CAS DataBase Reference)

EPA Substance Registry System

Ethylene glycol monomethyl ether acetate (110-49-6)

Safety Information

Hazard Codes 

T

Risk Statements 

60-61-20/21/22

Safety Statements 

53-45

RIDADR 

UN 1189 3/PG 3

WGK Germany 

1

RTECS 

KL5950000

Autoignition Temperature

380 °C DIN 51794

HS Code 

2915 39 00

HazardClass 

3

PackingGroup 

III

Hazardous Substances Data

110-49-6(Hazardous Substances Data)

Toxicity

LD50 orally in rats: 3.4 g/kg (Smyth)

IDLA

200 ppm

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Methoxyethyl acetate Usage And Synthesis

Description

Methoxyethyl acetate is a colorless liquid with a mild, ether-like odor. Odor threshold= 0.33 ppm. Molecular weight= 118.15; Specific gravity (H2O:1)= 1.01;Boiling point=145℃; Freezing/Melting point=65℃; Vapor pressure= 2 mmHg at 20℃; Flash point=48.9℃ (cc); Autoignition temperature=380℃. Explosive limits: LEL= 1.7%; UEL= 8.2%. Hazard Identification (based on NFPA-704 M Rating System): Health 1, Flammability 2, Reactivity 0. Soluble in water.

Chemical Properties

CLEAR LIQUID

Chemical Properties

Methoxyethyl acetate is a colorless liquid. Mild, ethereal odor.

Physical properties

Colorless liquid with a mild, ether-like odor. Experimentally determined detection and recognition odor threshold concentrations were 1.6 mg/m³ (330 ppb_v) and 3.1 mg/m³ (640 ppb_v), respectively (Hellman and Small, 1974).

Uses

Lacquer industry; textile printing; manufacture of photographic film, coatings, and adhesives

Uses

Industrial solvent.

General Description

A clear colorless liquid with a pleasant odor. Flash point of 135°F. Denser than water and soluble in water. Vapors are heavier than air.

Air & Water Reactions

Flammable. Water soluble. Reacts slowly in water to form acetic acid and methyl alcohol; the reaction is not violent.

Reactivity Profile

Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Hazard

Toxic by ingestion, inhalation, and skin absorption. Moderate fire risk. Toxic by skin absorption.

Health Hazard

May cause irritation if splashed into eyes. Can be absorbed through the skin. Swallowing a large single dose or absorbing larged amount through skin could result in death. It is unlikely that air levels of the compound would be dangerous unless it is heated.

Fire Hazard

Special Hazards of Combustion Products: Irritating vapors and toxic gases, such as carbon monoxide, may be formed when involved in fire.

Safety Profile

Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. hfddly toxic by inhalation and skin contact. Human systemic effects by inhalation: eye lachrymation, cough, and pulmonary changes. Experimental reproductive effects. Mutation data reported. An inhalation irritant in humans. An eye irritant. Flammable liquid when exposed to heat or flame; can react with oxidizing materials. A moderate explosion hazard. To fight fire, use CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also GLYCOL ETHERS.

Potential Exposure

Methoxyethyl acetate is used as a solvent for resins, oils, greases and inks. It is also an ingredient of lacquers, paints and adhesives.

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Medical observation is recommended for 2448 h after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a corticosteroid spray.

Environmental Fate

Chemical/Physical. Hydrolyzes in water forming methyl cellosolve and acetic acid. At an influent concentration of 1,024 mg/L, treatment with GAC resulted in an effluent concentration of 886 mg/L. The adsorbability of the carbon used was 28 mg/g carbon (Guisti et al., 1974).

storage

Color Code—Red: Flammability Hazard: Store in a flammable liquid storage area or approved cabinet away from ignition sources and corrosive and reactive materials. Prior to working with this chemical you should be trained on its proper handling and storage. Before entering confined space where this chemical may be present, check to make sure that an explosive concentration does not exist. 2-Methoxyethyl acetate must be stored to avoid contact with oxidizers (such as perchlorates, peroxides, permanganates, chlorates, and nitrates) and strong caustics, since violent reactions occur. Sources of ignition, such as smoking and open flames are prohibited where 2-methoxyethyl acetate is used, handled, or stored in a manner that could create a potential fire or explosion hazard. Wherever 2-methoxyethyl acetate is used, handled, manufactured, or stored, use explosion-proof electrical equipment and fittings.

Shipping

UN1189 Ethylene glycol monomethyl ether acetate, Hazard Class: 3; Labels: 3-Flammable liquid.

Purification Methods

Shake the methoxy-ethane with anhydrous Na2CO3, filter and distil it in a vacuum. Redistillation can be then be carried out at atmospheric pressure. [Dunbar & Bolstad J Org Chem 21 1041 1956, Beilstein 2 IV 214.]

Incompatibilities

Forms explosive mixture with air. Strong oxidants, strong bases, strong acids, and nitrates. May be able to form explosive peroxides.

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed. Beware of possible presence of peroxides in which case open burning may be used

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