trans-2-Aminocyclopentanol hydrochloride Chemical Properties

Melting point:

191-196 °C(lit.)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

powder to crystal

color 

White to Light yellow to Light orange

BRN 

4143621

InChI

InChI=1/C5H11NO.ClH/c6-4-2-1-3-5(4)7;/h4-5,7H,1-3,6H2;1H/t4-,5-;/s3

InChIKey

ZFSXKSSWYSZPGQ-TXRIQCMBNA-N

SMILES

[C@@H]1(O)CCC[C@H]1N.[H]Cl |&1:0,5,r|

CAS DataBase Reference

68327-11-7(CAS DataBase Reference)

Safety Information

WGK Germany 

3

HS Code 

29221990

MSDS

• Language:English Provider:SigmaAldrich

trans-2-Aminocyclopentanol hydrochloride Usage And Synthesis

Uses

(1R,2R)-2-Aminocyclopentanol hydrochloride is a useful research chemical.

Synthesis

To a 100 mL autoclave was added 15 g (70.7 mmol) of (R,R)-2-benzyloxycarbonylaminocyclopentanol and 0.3 g of 5% palladium-carbon catalyst, and 45 mL of degassed methanol under nitrogen protection. The reaction mixture was stirred under 2 MPa hydrogen pressure at 50 °C for 3 hours. Upon completion of the reaction, the palladium-carbon catalyst was removed by diatomaceous earth filtration. Concentrated hydrochloric acid was slowly added to the filtrate to adjust the pH to 3. Subsequently, the aqueous phase was concentrated to afford 7.9 g of trans-(-)-2-aminocyclopentanol hydrochloride in 79.2% yield.

References

[1] Patent: EP1398310, 2004, A1. Location in patent: Page 17
[2] Patent: EP1398310, 2004, A1. Location in patent: Page 17

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