Basic information Safety Supplier Related

FMoc-Val-Cit-PAB-PNP

Basic information Safety Supplier Related

FMoc-Val-Cit-PAB-PNP Basic information

Product Name:
FMoc-Val-Cit-PAB-PNP
Synonyms:
  • {4-[(2S)-5-(carbamoylamino)-2-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanamido]pentanamido]phenyl}methyl 4-nitrophenyl carbonate
  • Moc-Val-Cit-PAB-PNP
  • 4-[[(2S)-1-amino-5-(carbamoylamino)-1-oxopentan-2-yl]-[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
  • Fmoc-Val-Cit-PAB-PNP, >95%
  • FMoc-Val-Cit-PAB-PNP
  • (9H-fluoren-9-yl)methyl ((S)-3-methyl-1-(((S)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-1-oxobutan-2-yl)carbamate
  • L-Ornithinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-
  • FMOC-VAL-CIT-PAB-PNP (9-FLUORENYLMETHYLOXYCARBONYL-VALYL-CITRULLYL-(4-AMINOBENZYL)-(4-NITROPHENYL)CARBONATE)
CAS:
863971-53-3
MF:
C40H42N6O10
MW:
766.8
Product Categories:
  • Pharmaceutical
  • ADCs
  • ADC-Linker
  • ADC-Linkers
Mol File:
863971-53-3.mol
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FMoc-Val-Cit-PAB-PNP Chemical Properties

Melting point:
189 °C(dec.)
Boiling point:
1024.0±65.0 °C(Predicted)
Density 
1.335±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
form 
powder to crystal
pka
10.63±0.46(Predicted)
color 
White to Light yellow
Sequence
Fmoc-Val-Cit-PAB-PNP
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Safety Information

HS Code 
2924.29.7790
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FMoc-Val-Cit-PAB-PNP Usage And Synthesis

Description

Fmoc-Val-Cit-PAB-PNP is a a cleavable ADC linker used in antibody drug conjugate. The Val-Cit linker was designed to be cleaved by cathepsin B. PNP group is a good leaving group when reacting with amine bearing payload.

Biological Activity

Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker that can be used to synthesize antibody drug conjugates (ADCs).

FMoc-Val-Cit-PAB-PNPSupplier

Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd. Gold
Tel
13414494621
Email
chenchao02lzu@126.com
Changzhou PBpharmaceutical R&D Co.,Ltd Gold
Tel
0519-83990708
Email
lxy2046@yeah.net
Zhenjiang Renzhi Biotechnology Co., Ltd. Gold
Tel
18762678737
Email
751546636@qq.com
Heze Development Zone chuangli Chemical Co., Ltd. Gold
Tel
+86-530-529 6766,+86-15666160102 15666160102
Email
info@chuangli-chem.com
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com