FMoc-Val-Cit-PAB-PNP
FMoc-Val-Cit-PAB-PNP Basic information
- Product Name:
- FMoc-Val-Cit-PAB-PNP
- Synonyms:
-
- {4-[(2S)-5-(carbamoylamino)-2-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methylbutanamido]pentanamido]phenyl}methyl 4-nitrophenyl carbonate
- Moc-Val-Cit-PAB-PNP
- 4-[[(2S)-1-amino-5-(carbamoylamino)-1-oxopentan-2-yl]-[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
- Fmoc-Val-Cit-PAB-PNP, >95%
- FMoc-Val-Cit-PAB-PNP
- (9H-fluoren-9-yl)methyl ((S)-3-methyl-1-(((S)-1-((4-((((4-nitrophenoxy)carbonyl)oxy)methyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-1-oxobutan-2-yl)carbamate
- L-Ornithinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-
- FMOC-VAL-CIT-PAB-PNP (9-FLUORENYLMETHYLOXYCARBONYL-VALYL-CITRULLYL-(4-AMINOBENZYL)-(4-NITROPHENYL)CARBONATE)
- CAS:
- 863971-53-3
- MF:
- C40H42N6O10
- MW:
- 766.8
- Product Categories:
-
- Pharmaceutical
- ADCs
- ADC-Linker
- ADC-Linkers
- Mol File:
- 863971-53-3.mol
More
Less
FMoc-Val-Cit-PAB-PNP Chemical Properties
- Melting point:
- 189 °C(dec.)
- Boiling point:
- 1024.0±65.0 °C(Predicted)
- Density
- 1.335±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- form
- powder to crystal
- pka
- 10.63±0.46(Predicted)
- color
- White to Light yellow
- Sequence
- Fmoc-Val-Cit-PAB-PNP
More
Less
FMoc-Val-Cit-PAB-PNP Usage And Synthesis
Description
Fmoc-Val-Cit-PAB-PNP is a a cleavable ADC linker used in antibody drug conjugate. The Val-Cit linker was designed to be cleaved by cathepsin B. PNP group is a good leaving group when reacting with amine bearing payload.
Biological Activity
Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker that can be used to synthesize antibody drug conjugates (ADCs).
FMoc-Val-Cit-PAB-PNPSupplier
Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd. Gold
- Tel
- 13414494621
- chenchao02lzu@126.com
Changzhou PBpharmaceutical R&D Co.,Ltd Gold
- Tel
- 0519-83990708
- lxy2046@yeah.net
Zhenjiang Renzhi Biotechnology Co., Ltd. Gold
- Tel
- 18762678737
- 751546636@qq.com
YJ Pharma Gold
- Tel
- 13962794339 13962794339
- 3686954964@qq.com
Shanghai Topbiochem Technology Co., Ltd
- Tel
- 021-58170097
- info@topbiochem.com