FMoc-Val-Cit-PAB
FMoc-Val-Cit-PAB Basic information
- Product Name:
- FMoc-Val-Cit-PAB
- Synonyms:
-
- FMoc-Val-Cit-PAB
- Fmoc-Val-Cit-PAB-OH
- (9H-fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate
- L-Ornithinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
- (9H-fluoren-9-yl)methyl((S)-1-((())-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate
- (9H-fluoren-9-yl)methyl N-[(1S)-1-{[(1S)-4-(carbamoylamino)-1-{[4-(hydroxymethyl)phenyl]carbamoyl}butyl]carbamoyl}-2-methylpropyl]carbamate
- Fmoc-val-citrulline-para-aminobenzyl-OH
- (9H-fluoren-9-yl)methyl ((2S)-1-((1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate
- CAS:
- 159858-22-7
- MF:
- C33H39N5O6
- MW:
- 601.69
- Product Categories:
-
- ADCs
- ADC Linker
- ADC-Linker
- ADC-Linkers
- Mol File:
- 159858-22-7.mol
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FMoc-Val-Cit-PAB Chemical Properties
- Melting point:
- 204 °C(dec.)
- Boiling point:
- 914.2±65.0 °C(Predicted)
- Density
- 1.276±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- form
- powder to crystal
- pka
- 10.63±0.46(Predicted)
- color
- White to Almost white
- CAS DataBase Reference
- 159858-22-7
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FMoc-Val-Cit-PAB Usage And Synthesis
Uses
Fmoc-Val-Cit-PAB is a commonly used bridge for a degradable antibody-conjugated drug (ADC).
Description
Fmoc-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Fmoc can be deprotected under basic condition.
FMoc-Val-Cit-PABSupplier
Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd. Gold
- Tel
- 13414494621
- chenchao02lzu@126.com
Zhenjiang Renzhi Biotechnology Co., Ltd. Gold
- Tel
- 18762678737
- 751546636@qq.com
Changzhou PBpharmaceutical R&D Co.,Ltd Gold
- Tel
- 0519-83990708
- lxy2046@yeah.net
Hangzhou Sinoda Pharmaceutical Technology Co. LTD Gold
- Tel
- 0571-87213919 17306812703
- 3007955328@qq.com
Daicel Chiral Technologies (China)CO.,LTD
- Tel
- 021-50460086-9 15921403865
- han_yajun@dctc.daicel.com