Basic information Uses Safety Supplier Related

FMoc-Val-Cit-PAB

Basic information Uses Safety Supplier Related

FMoc-Val-Cit-PAB Basic information

Product Name:
FMoc-Val-Cit-PAB
Synonyms:
  • FMoc-Val-Cit-PAB
  • Fmoc-Val-Cit-PAB-OH
  • (9H-fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate
  • L-Ornithinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
  • (9H-fluoren-9-yl)methyl((S)-1-((())-1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate
  • (9H-fluoren-9-yl)methyl N-[(1S)-1-{[(1S)-4-(carbamoylamino)-1-{[4-(hydroxymethyl)phenyl]carbamoyl}butyl]carbamoyl}-2-methylpropyl]carbamate
  • Fmoc-val-citrulline-para-aminobenzyl-OH
  • (9H-fluoren-9-yl)methyl ((2S)-1-((1-((4-(hydroxymethyl)phenyl)amino)-1-oxo-5-ureidopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate
CAS:
159858-22-7
MF:
C33H39N5O6
MW:
601.69
Product Categories:
  • ADCs
  • ADC Linker
  • ADC-Linker
  • ADC-Linkers
Mol File:
159858-22-7.mol
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FMoc-Val-Cit-PAB Chemical Properties

Melting point:
204 °C(dec.)
Boiling point:
914.2±65.0 °C(Predicted)
Density 
1.276±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
form 
powder to crystal
pka
10.63±0.46(Predicted)
color 
White to Almost white
CAS DataBase Reference
159858-22-7
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Safety Information

HS Code 
2924.29.7790
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FMoc-Val-Cit-PAB Usage And Synthesis

Uses

Fmoc-Val-Cit-PAB is a commonly used bridge for a degradable antibody-conjugated drug (ADC).

Description

Fmoc-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Fmoc can be deprotected under basic condition.

FMoc-Val-Cit-PABSupplier

Shenzhen Yuzhong Pharmaceutical Technology Co., Ltd. Gold
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13414494621
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chenchao02lzu@126.com
Zhenjiang Renzhi Biotechnology Co., Ltd. Gold
Tel
18762678737
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751546636@qq.com
Changzhou PBpharmaceutical R&D Co.,Ltd Gold
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0519-83990708
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lxy2046@yeah.net
Hangzhou Sinoda Pharmaceutical Technology Co. LTD Gold
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0571-87213919 17306812703
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3007955328@qq.com
YJ Pharma Gold
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13962794339 13962794339
Email
3686954964@qq.com
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