Boc-N-amido-PEG3-sulfonic acid Chemical Properties

Density 

1.219±0.06 g/cm3(Predicted)

pka

1.34±0.50(Predicted)

Boc-N-amido-PEG3-sulfonic acid Usage And Synthesis

Description

t-Boc-N-amido-PEG3-sulfonic acid is a PEG linker containing a t-Boc protected amine group and a sulfonic acid. The t-Boc protecting group can be removed under acidic conditions so that the amine can be further reacted. The sulfonic acid can undergo esterification, halogenation and displacement reactions. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.

Uses

Boc-NH-PEG3-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Boc-N-amido-PEG3-sulfonic acid(1817735-32-2)Related Product Information

• t-Boc-N-Amido-PEG4-propargyl
• 2,2-DIMETHYL-4-OXO-3,8,11,14-TETRAOXA-5-AZAHEXADECAN-16-OIC ACID
• Boc-NH-PEG7-CH2CH2COOH
• 22-Amino-5,8,11,14,17,20-hexaoxa-2-azadocosanoic acid 1,1-dimethylethyl ester
• t-boc-N-amido-PEG5-azide
• t-Boc-N-amido-PEG5-acid
• Thiol-dPEG4-t-boc-N-amido
• t-Boc-N-Amido-PEG3-propargyl
• t-Boc-N-Amido-PEG4-Azide
• t-Boc-N-Amido-PEG6-Propargyl
• t-Boc-N-Amido-PEG4-Ms
• t-Boc-N-amido-PEG4-(CH2)3CO2H
• t-Boc-N-amido-PEG5-MS
• t-Boc-N-amido-PEG5-NHS ester
• t-Boc-N-Amido-PEG7-propargyl
• t-Boc-N-Amido-PEG5-propargyl
• 5,8,11-Trioxa-2-azatridecanoic acid, 13-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester
• t-Boc-N-Amido-PEG8-propargyl