t-Boc-N-Amido-PEG8-propargyl Chemical Properties

Boiling point:

565.0±50.0 °C(Predicted)

Density 

1.076±0.06 g/cm3(Predicted)

solubility 

Soluble in DMSO, DCM, DMF

pka

12.23±0.46(Predicted)

t-Boc-N-Amido-PEG8-propargyl Usage And Synthesis

Description

t-Boc-N-Amido-PEG8-propargyl has an alkyne group and Boc-protected amine. The alkyne group reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. The deprotection of Boc-protected amine can be peformed under mild acidic conditions. The hydrophilic PEG chain enhances the solubility of the molecule in aqueous solution.

Uses

Boc-NH-PEG8-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-NH-PEG8-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

t-Boc-N-Amido-PEG8-propargyl(2183440-31-3)Related Product Information

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