t-Boc-N-Amido-PEG8-propargyl

Product Name: t-Boc-N-Amido-PEG8-propargyl
CAS No.: 2183440-31-3
Chemical Name: t-Boc-N-Amido-PEG8-propargyl
Synonyms: Boc-NH-PEG8-Alkyne;Propargyl-PEG8-NHBoc;Boc-NH-PEG8-propargyl;Propargyl-PEG9-Boc Amine;t-Boc-N-Amido-PEG8-propargyl;tert-Butyl (3,6,9,12,15,18,21,24-octaoxaheptacos-26-yn-1-yl)carbamate;5,8,11,14,17,20,23,26-Octaoxa-2-azanonacos-28-ynoic acid, 1,1-dimethylethyl ester;Propargyl-PEG8-NHBoc/5,8,11,14,17,20,23,26-Octaoxa-2-azanonacos-28-ynoic acid, 1,1-dimethylethyl ester
CBNumber: CB24849672
Molecular Formula: C24H45NO10
Formula Weight: 507.61
MOL File: 2183440-31-3.mol

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t-Boc-N-Amido-PEG8-propargyl Property

Boiling point:: 565.0±50.0 °C(Predicted)
Density: 1.076±0.06 g/cm3(Predicted)
solubility: Soluble in DMSO, DCM, DMF
pka: 12.23±0.46(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-23850
Product name: t-Boc-N-Amido-PEG8-propargyl
Purity: 98%
Packaging: 100mg
Price: $280
Updated: 2021/12/16

BroadPharm

Product number: BP-23850
Product name: t-Boc-N-Amido-PEG8-propargyl
Purity: 98%
Packaging: 250mg
Price: $480
Updated: 2021/12/16

BroadPharm

Product number: BP-23850
Product name: t-Boc-N-Amido-PEG8-propargyl
Purity: 98%
Packaging: 500mg
Price: $750
Updated: 2021/12/16

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t-Boc-N-Amido-PEG8-propargyl Chemical Properties,Usage,Production

Description

t-Boc-N-Amido-PEG8-propargyl has an alkyne group and Boc-protected amine. The alkyne group reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. The deprotection of Boc-protected amine can be peformed under mild acidic conditions. The hydrophilic PEG chain enhances the solubility of the molecule in aqueous solution.

Uses

Boc-NH-PEG8-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-NH-PEG8-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

t-Boc-N-Amido-PEG8-propargyl Preparation Products And Raw materials

Raw materials

Preparation Products

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t-Boc-N-Amido-PEG8-propargyl Suppliers

China 30 United States 3 Global 33

Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883
Fax: 0731-82251112
Email: sales@huatengsci.com
Country: China
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Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
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Xi'an Confluore Biological Technology Co., Ltd.

Tel: +86-156-80926068 +86-15680926068
Email: 1924344760@qq.com
Country: China
ProdList: 4952
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Alfa Chemistry

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Fax: 1-516-927-0118
Email: Info@alfa-chemistry.com
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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Shaanxi Xinyan Bomei Biotechnology Co., Ltd.

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Guangzhou Hongyuan Chemical Co.,Ltd

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Zhengzhou Akem Chemical Co., Ltd

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Beijing Jin Ming Biotechnology Co., Ltd.

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Xi'an Qiyue Biotechnology Co., Ltd.

Tel: 400-400-6966-012-012 17778955912
Email: 2957605606@qq.com
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View Lastest Price from t-Boc-N-Amido-PEG8-propargyl manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Propargyl-PEG8-NHBoc 2183440-31-3
Price: US $0.00/g
Min. Order: 1g
Purity: >98.00%
Supply Ability: 1g
Release date: 2024-03-26

2183440-31-3, t-Boc-N-Amido-PEG8-propargylRelated Search:

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t-Boc-N-Amido-PEG8-propargyl

Boc-NH-PEG8-propargyl

Propargyl-PEG8-NHBoc

Propargyl-PEG9-Boc Amine

Boc-NH-PEG8-Alkyne

Propargyl-PEG8-NHBoc/5,8,11,14,17,20,23,26-Octaoxa-2-azanonacos-28-ynoic acid, 1,1-dimethylethyl ester

5,8,11,14,17,20,23,26-Octaoxa-2-azanonacos-28-ynoic acid, 1,1-dimethylethyl ester

tert-Butyl (3,6,9,12,15,18,21,24-octaoxaheptacos-26-yn-1-yl)carbamate

2183440-31-3

213440-31-3

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