t-Boc-N-amido-PEG5-MS
- Product Name
- t-Boc-N-amido-PEG5-MS
- CAS No.
- 2128735-28-2
- Chemical Name
- t-Boc-N-amido-PEG5-MS
- Synonyms
- Boc-NH-PEG5-Ms;Boc-N-Amido-PEG5-Ms;t-Boc-N-amido-PEG5-MS;5,8,11,14,17-Pentaoxa-18-thia-2-azanonadecanoic acid, 1,1-dimethylethyl ester, 18,18-dioxide
- CBNumber
- CB84680271
- Molecular Formula
- C16H33NO9S
- Formula Weight
- 415.5
- MOL File
- 2128735-28-2.mol
t-Boc-N-amido-PEG5-MS Property
- Boiling point:
- 542.5±50.0 °C(Predicted)
- Density
- 1.161±0.06 g/cm3(Predicted)
- pka
- 12.23±0.46(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BP-23788
- Product name
- t-Boc-N-Amido-PEG5-Ms
- Purity
- 98%
- Packaging
- 250mg
- Price
- $480
- Updated
- 2021/12/16
t-Boc-N-amido-PEG5-MS Chemical Properties,Usage,Production
Description
t-Boc-N-Amido-PEG5-Ms is a PEG linker that contains a Boc protecting group and a mesyl group. The t-Boc group can be removed under acidic conditions to produce a reactive free amine. The mesyl group is a good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases the water solubility of the compound. Longer PEG chains increase the water solubility properties of the compound.
Uses
Boc-N-Amido-PEG5-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
t-Boc-N-amido-PEG5-MS Preparation Products And Raw materials
Raw materials
Preparation Products
t-Boc-N-amido-PEG5-MS Suppliers
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View Lastest Price from t-Boc-N-amido-PEG5-MS manufacturers
- Product
- Boc-NH-PEG5-Ms 2128735-28-2
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-25