t-Boc-N-Amido-PEG4-Ms Chemical Properties

Boiling point:

510.9±45.0 °C(Predicted)

Density 

1.166±0.06 g/cm3(Predicted)

storage temp. 

Storage temp. 2-8°C

solubility 

Soluble in DCM

pka

12.22±0.46(Predicted)

form 

Liquid

color 

Colorless to light yellow

t-Boc-N-Amido-PEG4-Ms Usage And Synthesis

Description

t-Boc-N-Amido-PEG4-Ms is contains a t-Boc protected amine and a mesyl group. The t-Boc can be removed under acidic conditions. The mesyl group is a good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases the water solubility of the compound. Longer PEG chains increase the water solubility properties of the compound.

Uses

Boc-NH-PEG4-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

t-Boc-N-Amido-PEG4-Ms(1447797-72-9)Related Product Information

• t-Boc-N-Amido-PEG4-propargyl
• 2,2-DIMETHYL-4-OXO-3,8,11,14-TETRAOXA-5-AZAHEXADECAN-16-OIC ACID
• Boc-NH-PEG7-CH2CH2COOH
• 22-Amino-5,8,11,14,17,20-hexaoxa-2-azadocosanoic acid 1,1-dimethylethyl ester
• t-boc-N-amido-PEG5-azide
• t-Boc-N-amido-PEG5-acid
• Thiol-dPEG4-t-boc-N-amido
• t-Boc-N-amido-PEG4-(CH2)3CO2H
• t-Boc-N-amido-PEG5-MS
• t-Boc-N-amido-PEG5-NHS ester
• t-Boc-N-Amido-PEG7-propargyl
• t-Boc-N-Amido-PEG3-propargyl
• t-Boc-N-Amido-PEG6-Propargyl
• Boc-N-amido-PEG3-sulfonic acid
• t-Boc-N-Amido-PEG5-propargyl
• 5,8,11-Trioxa-2-azatridecanoic acid, 13-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester
• t-Boc-N-Amido-PEG8-propargyl