ChemicalBook > Product Catalog > Biochemical Engineering > Nucleoside drugs > Nucleoside Intermediates > 2'-O-Methylcytidine
2'-O-Methylcytidine
2'-O-Methylcytidine Basic information
- Product Name:
- 2'-O-Methylcytidine
- Synonyms:
-
- 2'-OMe-C
- 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]pyrimidin-2-one
- 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidin-2-one
- 4-azanyl-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]pyrimidin-2-one
- 2'-OMe Cytidine
- 4-aMino-1-[(2R,3R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)-3-Methoxyoxolan-2-yl]-1,2-dihydropyriMidin-2-one
- 2'-O-Methylcytidine, >98.0%(HPLC)
- 2'-O-Methylcytidine, >=99%
- CAS:
- 2140-72-9
- MF:
- C10H15N3O5
- MW:
- 257.24
- EINECS:
- 2017-001-1
- Product Categories:
-
- Bases & Related Reagents
- Carbohydrates & Derivatives
- Biochemicals and Reagents
- Nucleosides, Nucleotides, Oligonucleotides
- Heterocycles
- Nucleotides
- Nucleoside Analogs
- Nucleosides
- Modified（deoxy）nucleoside
- Nucleosides-2'-OMe Nucleosides
- Mol File:
- 2140-72-9.mol
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2'-O-Methylcytidine Chemical Properties
- Melting point:
- 252-253 C
- Boiling point:
- 506.0±60.0 °C(Predicted)
- Density
- 1.68±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble in DMSO.
- pka
- 13.37±0.70(Predicted)
- form
- Powder
- color
- White to Off-white
- PH
- 4.2
- λmax
- 281 (pH 1)；273 (EtOH)
- InChI
- InChI=1S/C10H15N3O5/c1-17-8-7(15)5(4-14)18-9(8)13-3-2-6(11)12-10(13)16/h2-3,5,7-9,14-15H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,9-/m1/s1
- InChIKey
- RFCQJGFZUQFYRF-ZOQUXTDFSA-N
- SMILES
- OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](OC)[C@@H]1O
- CAS DataBase Reference
- 2140-72-9(CAS DataBase Reference)
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Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-24/25
- WGK Germany
- 3
- HS Code
- 29349990
MSDS
- Language:English Provider:SigmaAldrich
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2'-O-Methylcytidine Usage And Synthesis
Description
2'-O-Methylcytidine is a nucleoside with a hydroxyl group on the 2' carbon, making it an effective viral replication inhibitor. 2'-O-Methylcytidine is also metabolized by nucleotide salvage pathways and may be able to bind to the response element on DNA, which could inhibit protein synthesis in cancer cells. It is an inhibitor of hepatitis C virus (HCV) non-structural protein 5B (NS5B; IC50 = 3.8 μM). It inhibits HCV replication in a replicon assay (IC50 = 21.2 μM).
Chemical Properties
White powder
Uses
2'-O-Methylcytidine is used in the preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.
Uses
Cytidine analog.
Definition
ChEBI: 2'-O-methylcytidine is a methylcytidine.
2'-O-MethylcytidineSupplier
Zhejiang Huida Biotech Co., LTD Gold
- Tel
- 0571-0571-89903882 15990081639
- sunshixuan@huidabiotech.com
Jiangsu Synthgene Biotechnology Co.,Ltd. Gold
- Tel
- 18136497538
- znf@syngenebio.com
Wuhu Huaren Science and Technology Co., Ltd. Gold
- Tel
- 0553-0553-0553-5842013-801-801 18155347026
- jinhuaren@huarensh.com
Hefei Huana Biomedical Technology Co.,Ltd Gold
- Tel
- 17333066501
- shengwen.fang@huanaok.com.cn
Allbiosyn Biotechnology Co.,LTD Gold
- Tel
- 18666985712
- info@allbiosyn.com
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2'-O-Methylcytidine(2140-72-9)Related Product Information
- (Trifluoromethoxy)benzene
- Anisole
- Methoxyacetic acid
- 4-Methoxybenzoic acid
- p-Anisidine
- p-Anisaldehyde
- Methoxydiethylborane
- POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE
- 2'-O-Methyl-N4-Benzoyl-5'-O-DMT-Cytidine
- (R)-(-)-TETRAHYDROFURFURYL ALCOHOL
- (S)-(+)-1-DIMETHYLAMINO-2-PROPANOL
- 3-Methylcytidine
- 2''-METHYLCYTIDINE,2'-C-METHYLCYTIDINE
- 2''-DEOXY-5-METHYLCYTIDINE (5-METHYL-2''-DEOXYCYTIDINE),2'-DEOXY-5-METHYLCYTIDINE
- N4-BENZOYL-2'-O-METHYLCYTIDINE
- 2'-O-Methyl-N4-Acetyl-5'-O-DMT-Cytidine
- 5-Methylcytidine
- N4-Acetyl-2'-O-Methyl-cytidine