Basic information Chemical properties Penetration enhancer Application References Safety Supplier Related

Laurocapram

Laurocapram, also known as azone, lauric Lun, N-lauryl caprolactam, quinacridone, nitrogen ketone. Its chemical name is 1-n-dodecyl azetidin-2-one, which is a new high security penetration enhancer. It is colorless transparent liquid at room temperature, slightly viscous, odorless. It can form emulsion with water, soluble in various organic solvents, and it has good lubricity, which promote the hydrophilic and lipophilic drug product activity or cosmetics nutrients to penetrate into the skin, greatly reducing the drug remain time in the stratum corneum, significantly enhancing drug efficacy and cosmetic results. Thus, we can reduce the amount of primary medical and reduce costs. Azone transdermal absorption enhancing effect lags behind.

Basic information Chemical properties Penetration enhancer Application References Safety Supplier Related

Laurocapram Basic information

Product Name:
Laurocapram
Synonyms:
  • n0252
  • acecloguanosine
  • N-Dodecyl Nitrogen Heterocyclic Heptane-2-Ketone
  • Lauocapram
  • Azone, Laurocapram
  • DODECYLAZACYCLOHEPTAN-2-ONE
  • 1-n-Dodecylazacycloneptan-2-one
  • 1-Dodecylhexahydro-1H-azepine-2-one
CAS:
59227-89-3
MF:
C18H35NO
MW:
281.48
EINECS:
261-668-9
Product Categories:
  • Cosmetic
  • Pharmaceutical intermediates, pharmaceutical raw materials
  • ketone
  • 59227-89-3
  • bc0001
  • john's
Mol File:
59227-89-3.mol
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Laurocapram Chemical Properties

Melting point:
-7°
Boiling point:
bp50m 160°
Density 
0.906-0.926
refractive index 
1.470-1.473
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka
-0.43±0.20(Predicted)
form 
Oil
color 
Colourless
Merck 
14,5385
LogP
6.570 (est)
CAS DataBase Reference
59227-89-3(CAS DataBase Reference)
EPA Substance Registry System
Laurocapram (59227-89-3)
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Safety Information

Safety Statements 
24/25
RTECS 
CM3995000
HS Code 
29339900
Hazardous Substances Data
59227-89-3(Hazardous Substances Data)
Toxicity
LD50 rats, mice (g/kg): 8 i.v., i.p. (Stoughton)
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Laurocapram Usage And Synthesis

Chemical properties

Colorless or slightly yellow transparent liquid, insoluble in water, it can form emulsion with water, soluble in various organic solvents.

Penetration enhancer

Laurocapram, also known as azone, lauric Lun, N-lauryl caprolactam, quinacridone, nitrogen ketone. Its chemical name is 1-n-dodecyl azetidin-2-one, which is a new high security penetration enhancer. It is colorless transparent liquid at room temperature, slightly viscous, odorless. It can form emulsion with water, soluble in various organic solvents, and it has good lubricity, which promote the hydrophilic and lipophilic drug product activity or cosmetics nutrients to penetrate into the skin, greatly reducing the drug remain time in the stratum corneum, significantly enhancing drug efficacy and cosmetic results. Thus, we can reduce the amount of primary medical and reduce costs. Azone transdermal absorption enhancing effect lags behind.
Laurocapram on hydrophilic and lipophilic drugs have significantly transdermal Aided role.  It has good aided effect on many kinds of plant extracts in emulsion state or colloidal state, and alkaloids effect is particularly evident. Transdermal penetration is stronger than dimethyl sulfoxide. 8-bromo cyclic nucleotide containing 1% azone permeability effect is equivalent to 12 times the 50% dimethyl sulfoxide. Often in combination with propylene glycol, synergy, the best use of transdermal concentration of 0.1% to 5%, safe and low toxic, non-irritating. The chemical property is stable, and it is kept up to four years at the room temperature.
It can be considered a decyl methyl sulfoxide with pyrrolidone composite for good novel penetration enhancers, skin irritation. It can promote the drug through the skin barrier corticosteroids, indomethacin, fluorouracil, hydroquinone and many other drugs transdermal absorption, improving local and systemic blood concentration, and improving the bioavailability of the drug. Lipophilic, they have transdermal effect for hydrophilic drugs. It can soften the skin and enhance its permeability. They have anti-inflammatory, analgesic and anti-itching effect. Low toxicity, oral LD50> 7g/kg, it is not compatible with strong acids or Vaseline to avoid reduce the effect.

Application

Laurocapram is used as the penetration enhancer in cosmetic preparations and personal-care products. Laurocapram is combined as an excipient (an inert substance) not an active ingredient. Excipients are added to ensure that the shelf-life of the active ingredients can be long enough to be active until internal use. It can be used as a topical smear, massage penetration enhancers; pesticides, as a pro-absorbing agent and sterilization plant growth regulators, pesticides pro penetration; in addition, can be used for coloring and dyeing leather and other areas of accelerator.

References

http://www.chemicalland21.com/lifescience/foco/LAUROCAPRAM.htm

Uses

antifungal lipopeptide

Uses

Laurocapram is a useful intermediate.

Uses

Pharmaceutic aid (excipient).

Laurocapram Preparation Products And Raw materials

Preparation Products

Raw materials

LaurocapramSupplier

TINAMEN Gold
Tel
15607209205
Email
tianmenzhengyi@qq.com
Products Intro
Product Name:Laurocapram
CAS:59227-89-3
Purity:97.0—102% Package:500ml;1KG;5KG
Jiangxi Xinsen Natural Vegetable Oil Co., Ltd. Gold
Tel
0796-8284836 17379666713
Email
592432494@qq.com
Products Intro
Product Name:Laurocapram
CAS:59227-89-3
Package:1kg/RMB 140;5kg10kg
Jiangxi Xuesong Natural Medicinal Oil Co. LTD Gold
Tel
18679669723 18679669723
Email
2134411736@qq.com
Products Intro
Product Name:Laurocapram
CAS:59227-89-3
Purity:99% Package:1kg;25kg
Jiangxi Planty Manor Health Industry Co., Ltd. Gold
Tel
0796-18507969315 18507969315
Email
3686433662@qq.com
Products Intro
Product Name:Laurocapram
CAS:59227-89-3
Purity:99% Package:1kg;25kg
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Email
sales@boylechem.com
Products Intro
Product Name:LaurocapraM
CAS:59227-89-3