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Doxylamine succinate

Basic information Safety Supplier Related

Doxylamine succinate Basic information

Product Name:
Doxylamine succinate
Synonyms:
  • LABOTEST-BB LT00244822
  • DOXYLAMINE SUCCINATE
  • DOXYLAMINE SUCCINATE SALT
  • 2-(alpha-(2-(dimethylamino)ethoxy)-alpha-methylbenzyl)-pyridinsuccinate(1
  • 2-(alpha-(2-dimethylaminoethoxy)-alpha-methylbenzyl)pyridinesuccinate
  • 2-dimethylaminoethoxyphenylmethyl-2-picolinesuccinate
  • alsadorm
  • decapryn
CAS:
562-10-7
MF:
C21H28N2O5
MW:
388.46
EINECS:
209-228-7
Product Categories:
  • API
  • DECAPRYN
  • Antagonists
  • Histaminergics
  • Neurotransmitters
  • Other APIs
  • Amines
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Neurochemicals
  • Pharmaceuticals
Mol File:
562-10-7.mol
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Doxylamine succinate Chemical Properties

Melting point:
95-98?C
Flash point:
9℃
storage temp. 
2-8°C
solubility 
Very soluble in water, freely soluble in ethanol (96 per cent).
form 
Solid
color 
White to Off-White
Stability:
Stable, but may be light sensitive. Incompatible with strong oxidizing agents, acids, bases.
InChIKey
KBAUFVUYFNWQFM-UHFFFAOYSA-N
LogP
2.519 (est)
CAS DataBase Reference
562-10-7(CAS DataBase Reference)
IARC
3 (Vol. 79) 2001
EPA Substance Registry System
Doxylamine succinate (1:1) (562-10-7)
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Safety Information

Hazard Codes 
Xn,T,F
Risk Statements 
22-36/37/38-20/21/22-39/23/24/25-23/24/25-11
Safety Statements 
26-36/37-45-16-7
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
2
RTECS 
US9275000
HS Code 
2933399090
Toxicity
LD50 in mice, rabbits (mg/kg): 470, 250 orally; 62, 49 i.v.; in mice, male rats, female rats (mg/kg): 460, 440, 445 s.c. (Brown, Werner)

MSDS

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Doxylamine succinate Usage And Synthesis

Chemical Properties

white to light cream powder

Uses

antihistaminic, hypnotic

Uses

Doxylamine succinate salt has been used as a therapeutic drug to check developmental toxicity.

Uses

H1 Histamine receptor antagonist. Antihistaminic; sedative; hypnotic.

Definition

ChEBI: Doxylamine succinate is an organic molecular entity.

brand name

Decapryn (Sanofi Aventis); Unisom (Pfizer).

General Description

The acid succinate salt (bisuccinate)of doxylamine, 2-[ -[2-(dimethylamino)ethoxy]- -methylbenzyl]pyridine bisuccinate (Decapryn Succinate), isa white to creamy-white powder with a characteristic odor.It is soluble in water (1:1), alcohol (1:2), and chloroform(1:2). A 1% solution has a pH of about 5.Doxylamine succinate is comparable in potency todiphenhydramine. It is indicated for the relief of seasonalrhinitis symptoms, but is also used as a nighttime sedative.Concurrent use of alcohol and other CNS depressantsshould be avoided.

General Description

White or creamy white powder. pH (1% aqueous solution) between 4.9 and 5.1.

Air & Water Reactions

Water soluble.

Health Hazard

SYMPTOMS: Symptoms of exposure to Doxylamine succinate may include drowsiness, excitability, nervousness, dizziness and sleeplessness.

Fire Hazard

Flash point data for Doxylamine succinate are not available. Doxylamine succinate is probably combustible.

Biochem/physiol Actions

H1 histamine receptor antagonist; hypnotic.Doxylamine suppresses histamine at the H1 receptor. It is associated with the short term management of insomnia and temporary relief of common cold symptoms. On the other hand, doxylamine intoxication is linked with rhabdomyolysis and secondary acute renal failure.Studies in mice show that doxylamine induces liver microsomal cytochrome P450 and other enzymes involved in thyroxine (T4) metabolism. In combination with pyridoxine hydrochloride, this drug is used to treat morning sickness.

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