Doxylamine succinate Chemical Properties

Melting point:

95-98?C

Flash point:

9℃

storage temp. 

2-8°C

solubility 

Very soluble in water, freely soluble in ethanol (96 per cent).

color 

White to Off-White

Stability:

Stable, but may be light sensitive. Incompatible with strong oxidizing agents, acids, bases.

InChIKey

KBAUFVUYFNWQFM-UHFFFAOYSA-N

LogP

2.519 (est)

CAS DataBase Reference

562-10-7(CAS DataBase Reference)

IARC

3 (Vol. 79) 2001

EPA Substance Registry System

Doxylamine succinate (1:1) (562-10-7)

Safety Information

Hazard Codes 

Xn,T,F

Risk Statements 

22-36/37/38-20/21/22-39/23/24/25-23/24/25-11

Safety Statements 

26-36/37-45-16-7

RIDADR 

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany 

2

RTECS 

US9275000

HS Code 

2933399090

Toxicity

LD50 in mice, rabbits (mg/kg): 470, 250 orally; 62, 49 i.v.; in mice, male rats, female rats (mg/kg): 460, 440, 445 s.c. (Brown, Werner)

MSDS

• Language:English Provider:SigmaAldrich

Doxylamine succinate Usage And Synthesis

Chemical Properties

white to light cream powder

Uses

antihistaminic, hypnotic

Uses

Doxylamine succinate salt has been used as a therapeutic drug to check developmental toxicity.

Uses

H1 Histamine receptor antagonist. Antihistaminic; sedative; hypnotic.

Definition

ChEBI: Doxylamine succinate is an organic molecular entity.

brand name

Decapryn (Sanofi Aventis); Unisom (Pfizer).

General Description

The acid succinate salt (bisuccinate)of doxylamine, 2-[ -[2-(dimethylamino)ethoxy]- -methylbenzyl]pyridine bisuccinate (Decapryn Succinate), isa white to creamy-white powder with a characteristic odor.It is soluble in water (1:1), alcohol (1:2), and chloroform(1:2). A 1% solution has a pH of about 5.Doxylamine succinate is comparable in potency todiphenhydramine. It is indicated for the relief of seasonalrhinitis symptoms, but is also used as a nighttime sedative.Concurrent use of alcohol and other CNS depressantsshould be avoided.

General Description

White or creamy white powder. pH (1% aqueous solution) between 4.9 and 5.1.

Air & Water Reactions

Water soluble.

Health Hazard

SYMPTOMS: Symptoms of exposure to Doxylamine succinate may include drowsiness, excitability, nervousness, dizziness and sleeplessness.

Fire Hazard

Flash point data for Doxylamine succinate are not available. Doxylamine succinate is probably combustible.

Biochem/physiol Actions

H1 histamine receptor antagonist; hypnotic.Doxylamine suppresses histamine at the H1 receptor. It is associated with the short term management of insomnia and temporary relief of common cold symptoms. On the other hand, doxylamine intoxication is linked with rhabdomyolysis and secondary acute renal failure.Studies in mice show that doxylamine induces liver microsomal cytochrome P450 and other enzymes involved in thyroxine (T4) metabolism. In combination with pyridoxine hydrochloride, this drug is used to treat morning sickness.

Doxylamine succinate(562-10-7)Related Product Information

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