SENKIRKIN
SENKIRKIN Basic information
- Product Name:
- SENKIRKIN
- Synonyms:
-
- RENARIDINE
- SENKIKIN
- SENKIRKIN
- (4Z)-4-Ethylidene-7-hydroxy-6,7,14-trimethyl-2,9-dioxa-14-azabicyclo[9.5.1]heptadec-11-ene-3,8,17-trione
- 11,16-trione,12-hydroxy-4-methyl-8-secosenecionan-8
- 2,12-Dihydroxy-4-methyl-11,16-dioxosenecionanium
- 4,8-Secosenecionan-8,11,16-trione, 12-hydroxy-4-methyl-
- 8,12-dihydroxy-4-methyl-11,16-dioxo-senecionaniu
- CAS:
- 2318-18-5
- MF:
- C19H27NO6
- MW:
- 365.42
- Product Categories:
-
- Heterocycles
- Mutagenesis Research Chemicals
- Mol File:
- 2318-18-5.mol
SENKIRKIN Chemical Properties
- Melting point:
- 197°C
- Boiling point:
- 497.19°C (rough estimate)
- Density
- 1.2439 (rough estimate)
- refractive index
- 1.5180 (estimate)
- storage temp.
- -20°C
- pka
- 12.67±0.40(Predicted)
- LogP
- 0.690 (est)
- IARC
- 3 (Vol. 31, Sup 7) 1987
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 22
- RIDADR
- 1544
- WGK Germany
- 3
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Hazardous Substances Data
- 2318-18-5(Hazardous Substances Data)
SENKIRKIN Usage And Synthesis
Description
A further hepatotoxiC alkaloid present in Senecio kirkii Hook, S. renardi and Nardosrnia laevigata. The base has [α]25D - 16° (c 1.89, MeOH) or[α]15D - 6.2° (c 1.91, CHCI3). It forms colourless plates when crystallized from either Me2CO or AcOEt and yields a picrate, m.p. 225.5-226°C and a picrolonate, m.p. 109- 110°C. The ultraviolet spectrum shows a single absorption maximum at 219 mp.. Several crystalline salts and derivatives are known, e.g. the aurichloride, m.p. 182.5-183.5°C; platinichloride, m.p. 196-7°C (dec.); bitartrate, m.p. 201°C; reineckate, m.p. 169-171°C; picrate, m.p. 225- 225.5°C; picrolonate, m.p. 138°C and the methiodide, m.p. 194-6°C (dec.). The O-acetate occurs naturally (q.v.) in Senecio kirkii.
Definition
ChEBI: Senkirkine is a macrolide.
Safety Profile
Poison by ingestion and intraperitoneal routes. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Nox
References
Briggs, Mangan, Russell., J. Chern. Soc., 1891 (1948)
Massagetov, Kuzovkov.,J. Gen. Chern., USSR, 23, 158 (1953)
Danilova, Konovalova., ibid, 30, 1921 (1961)
Danilova, Koretskaya, Utkin., ibid, 31, 3815 (1961)
Wunderlich., Chern. Ind., 2089 (1962)
Briggs et al., J. Chern. Soc., 2492 (1965)
SENKIRKINSupplier
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Tel
- 86-029-85456576
- daisy_wang@vip.163.com
- Tel
- 021-51320588
- tauto@tautobiotech.com
- Tel
- 027-87465837 19945049750
- sales@finetechnology-ind.com
SENKIRKIN(2318-18-5)Related Product Information
- alpha-Terpineol
- alpha-Cyperone
- beta-Sitosterol
- Hydroxyecdysone
- hydroxygenkwanin
- 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one
- Artemether
- MOSLOFLAVONE
- beta-Eudesmol
- (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one
- SENKIRKIN
- (S)-ALLYL LACTATE
- 1,4-DIACETOXY-2-OXOBUTANE