4-PIPERAZIN-1-YL-PHENYLAMINE Chemical Properties

Melting point:

119-123 °C (lit.)

Boiling point:

380.2±27.0 °C(Predicted)

Density 

1.107±0.06 g/cm3(Predicted)

storage temp. 

2-8°C, protect from light

form 

Powder

pka

9.12±0.10(Predicted)

color 

White to purple

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-37/38-41

Safety Statements 

26-39

WGK Germany 

2

HS Code 

2933998090

MSDS

• Language:English Provider:SigmaAldrich

4-PIPERAZIN-1-YL-PHENYLAMINE Usage And Synthesis

Uses

4-Piperazinoaniline(CAS#67455-41-8)is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.

Synthesis

General procedure for the synthesis of 1-(4-aminophenyl)piperazine from 1-(4-nitrophenyl)piperazine: 1-(4-nitrophenyl)piperazine (414 mg, 2 mmol) was dissolved in a mixed solvent of ethanol (15 mL) and tetrahydrofuran (15 mL), and 10% palladium/carbon catalyst (50 mg) was added. The reaction was stirred for 3 h at room temperature under hydrogen atmosphere. The progress of the reaction was monitored by thin layer chromatography (TLC) during the reaction. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad to remove the catalyst. The filtrate was concentrated under reduced pressure to afford the target product 1-(4-aminophenyl)piperazine (319 mg, 90.0% yield).

References

[1] Synthetic Communications, 2012, vol. 42, # 2, p. 213 - 222
[2] RSC Advances, 2015, vol. 5, # 113, p. 93433 - 93437
[3] Green Chemistry, 2017, vol. 19, # 14, p. 3400 - 3407
[4] Tetrahedron Letters, 1999, vol. 40, # 31, p. 5655 - 5659
[5] Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry, 2011, vol. 41, # 1, p. 114 - 119

4-PIPERAZIN-1-YL-PHENYLAMINE(67455-41-8)Related Product Information

• 1-METHYL-4-(4-NITROPHENYL)PIPERAZINE
• 1-(4-Nitrophenyl)piperazine
• 4-(4-Methylpiperazino)aniline
• 2-PIPERAZIN-1-YL-PHENYLAMINE
• 3-(4-Methylpiperazin-1-yl)aniline
• 3-CHLORO-4-(4-METHYL-PIPERAZIN-1-YL)-PHENYLAMINE
• 3-Fluoro-4-(4-methylpiperazin-1-yl)aniline
• 2-(4-METHYL-PIPERAZIN-1-YL)-PHENYLAMINE
• 4-[4-(4-METHYLOXY-PHENYL)-PIPERAZIN-1-YL]-PHENYLAMINE
• 4-(4-ETHYL-PIPERAZIN-1-YL)-PHENYLAMINE
• BUTTPARK 83\09-70
• N-[4-(4-METHYLPIPERAZINO)PHENYL]PENTANAMIDE
• 4-(4-BENZYL-PIPERAZIN-1-YL)-PHENYLAMINE
• N-[4-(4-METHYLPIPERAZINO)PHENYL]ACETAMIDE
• 2,2-DIMETHYL-N-[4-(4-METHYLPIPERAZINO)PHENYL]PROPANAMIDE
• 2-(4-METHANESULFONYL-PIPERAZIN-1-YL)-PHENYLAMINE
• 3-PIPERAZIN-1-YL-PHENYLAMINE DOUBLE HYDROCHLORIDE
• 2,4-BIS-(4-METHYL-PIPERAZIN-1-YL)-PHENYLAMINE