(S)-1-Boc-3-methylpiperazine Chemical Properties

Melting point:

40-45 °C

alpha 

-16 º (c=1 in dioxane)

Boiling point:

268.7±15.0 °C(Predicted)

Density 

0.997±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

form 

Crystalline Powder

pka

8.52±0.40(Predicted)

color 

White to yellow

optical activity

[α]/D -16±2°, c = 1 in dioxane

Sensitive 

Air Sensitive

InChI

InChI=1S/C10H20N2O2/c1-8-7-12(6-5-11-8)9(13)14-10(2,3)4/h8,11H,5-7H2,1-4H3/t8-/m0/s1

InChIKey

FMLPQHJYUZTHQS-QMMMGPOBSA-N

SMILES

N1(C(OC(C)(C)C)=O)CCN[C@@H](C)C1

CAS DataBase Reference

147081-29-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

37/38-41-34

Safety Statements 

26-39-45-36/37/39

RIDADR 

3259

WGK Germany 

3

F 

10-34

HS Code 

29335990

MSDS

• Language:English Provider:SigmaAldrich

(S)-1-Boc-3-methylpiperazine Usage And Synthesis

Description

(S)-1-Boc-3-methylpiperazine is a hydrophobic compound that is structurally modified from the tetracyclic family of drugs. It has been shown to inhibit tumor cell growth by binding to the oncogene, KRASG12C, and downregulating its expression. This compound also inhibits cancer cell growth through the inhibition of the PI3K/AKT signaling pathway. The pharmacological effects of (S)-1-Boc-3-methylpiperazine are dependent on its ability to bind with high affinity to KRASG12C and inhibit its activity.

Chemical Properties

colorless to yellow liquid

Uses

Laboratory chemicals, Manufacture of substances.

Uses

Reactant involved in the synthesis of biologically activy molecules including:

• CCR5 antagonists with anti-HIV-1 activity
• Opioid receptor antagonists
• Human growth hormone secretagogue receptor antagonists for treatment of obesity
• Fatty acid oxidation inhibitors

Uses

(S)-4-Boc-2-methylpiperazine ((S)-1-Boc-3-methylpiperazine) is a reagent used in the synthesis of benzamide peptidomimetic as non-ATP competitive inihbitors.

(S)-1-Boc-3-methylpiperazine(147081-29-6)Related Product Information

• (S)-1-Boc-3-benzylpiperazine
• (S)-tert-butyl 3-formylpiperidine-1-carboxylate
• (3S)-3-AMinoazepane-1-carboxylic Acid tert-Butyl Ester
• (S)-1-N-Boc-3-ethylpiperazine
• (S)-1-BOC-3-PROPYLPIPERAZINE
• R-N-4-Boc-N-1-Cbz-2-piperazine carboxylic acid
• N-4-Boc-2-piperazinecarboxylic acid
• (S)-1-Boc-3-methylpiperazine
• 1-BOC-3,5-DIMETHYL-PIPERAZINE
• t-Butyl(2R,5S)-2,5-dimethylpiperazine-1-carboxylate
• (R)-4-N-Boc-piperazine-2-carboxylic acid methyl ester
• (R)-1-BOC-3-(Hydroxymethyl)piperazine
• (S)-2-tert-Butylcarboxamide-4-tert-butoxycarbonyl piperazine
• (1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE
• (S)-1-N-Boc-2-methylpiperazine
• 4-N-Boc-2-Methyl-piperazine
• 1-Boc-2-Methylpiperazine
• (R)-1-Boc-3-methylpiperazine