(R)-1-Boc-3-methylpiperazine Chemical Properties

Melting point:

40-45 °C

Boiling point:

268.7±15.0 °C(Predicted)

Density 

0.997±0.06 g/cm3(Predicted)

Flash point:

223 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

8.52±0.40(Predicted)

form 

Crystalline Powder

color 

White

optical activity

[α]/D +16±2°, c = 1 in dioxane

InChIKey

FMLPQHJYUZTHQS-MRVPVSSYSA-N

CAS DataBase Reference

163765-44-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

37/38-41-36/37/38

Safety Statements 

26-39-37/39

WGK Germany 

3

F 

10-34

HS Code 

29335990

MSDS

• Language:English Provider:SigmaAldrich

(R)-1-Boc-3-methylpiperazine Usage And Synthesis

Chemical Properties

White solid

Uses

(R)-4-Boc-2-methylpiperazine is a reagent used in organic synthesis. Used in the synthesis of orally bioavailable inhibitors of 11-β-hydroxysteroid. (R)-4-Boc-2-methylpiperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Synthesis

To a solution of (R)-methylpiperazine (400 mg) in dichloromethane (20 mL) at 0 ℃ was added di-tert-butyl dicarbonate (871 mg). The reaction was stirred at room temperature for 4 h and then quenched with water (20 mL), followed by extraction into dichloromethane (2 x 40 mL). The combined organics were washed with saturated aqueous brine solution (40 mL), dried (MgSO4), and concentrated to give (R)-1-Boc-3-methylpiperazine as a white solid (669 mg, 84%).

(R)-1-Boc-3-methylpiperazine(163765-44-4)Related Product Information

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