Trimethylacetic anhydride Chemical Properties

Boiling point:

193 °C(lit.)

Density 

0.918 g/mL at 25 °C(lit.)

vapor pressure 

62.1Pa at 25℃

refractive index 

n20/D 1.409(lit.)

Flash point:

135 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Miscible with acetonitrile.

form 

Liquid

color 

Clear colorless

Sensitive 

Moisture Sensitive

BRN 

386552

InChI

InChI=1S/C10H18O3/c1-9(2,3)7(11)13-8(12)10(4,5)6/h1-6H3

InChIKey

PGZVFRAEAAXREB-UHFFFAOYSA-N

SMILES

C(C)(C)(C)C(=O)OC(=O)C(C)(C)C

LogP

2.15

CAS DataBase Reference

1538-75-6(CAS DataBase Reference)

EPA Substance Registry System

Propanoic acid, 2,2-dimethyl-, anhydride (1538-75-6)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2920 8/PG 2

WGK Germany 

3

F 

9-13-21

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29159000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Trimethylacetic anhydride Usage And Synthesis

Description

Trimethylacetic anhydride is a pivalic acid derivative that is used in organic synthesis. The compound's reaction mechanism is believed to be the formation of an alkanoic acid, which reacts with a hydroxyl group to form an anhydride. Trimethyl acetic anhydride has been shown to have pharmacokinetic properties and can be used as a nonsteroidal anti-inflammatory drug. This compound has also been found to have a matrix effect on crystalline cellulose and is capable of forming nitrogen-containing carboxylic acids.

Chemical Properties

clear colourless liquid

Uses

A metabolite of a double prodrug (6-dGCV-DPiv

Uses

Trimethylacetic anhydride was used:

• in solid-phase oligonucleotide synthesis
• in kinetic resolution of racemic 2-hydroxy-γ-butyrolactones with diphenylacetic acid
• as acylation and esterification reagent for anilines
• as acylation and esterification reagent for phenols

Flammability and Explosibility

Not classified

Trimethylacetic anhydride(1538-75-6)Related Product Information

• Iodomethyl pivalate
• Pivalic acid
• silver pivalate
• zinc pivalate
• 4-Dimethylaminopyridine
• PotassiuM triMethylacetate, 95%
• Pivaldehyde
• Ethyl trimethylacetate
• DIISOBUTYL ETHER
• Isobutyl propionate
• Isobutyl isobutyrate
• ISOBUTYRIC ACID N-PROPYL ESTER
• VALERIC ANHYDRIDE
• Propionic anhydride
• Methyl trimethylacetate
• Isobutyl acetate
• Isobutyl formate
• TRIMETHYLACETIC ANHYDRIDE