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ERYTHROMYCIN B

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ERYTHROMYCIN B Basic information

Product Name:
ERYTHROMYCIN B
Synonyms:
  • Erythromycin B/3R,4S,5S,6R,7R,9R,11R,12S,13R,14R)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-7,12-dihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3,5,7,9,11,13-hex
  • ERYTHROMYCIN B (150 MG)
  • 12-deoxy-erythromyci
  • 12-deoxyerythromycin
  • abbot24091
  • berythromycin
  • Erythromycin B (100 mg)
  • 12-DeoxyerythroMycin, BerythroMycin
CAS:
527-75-3
MF:
C37H67NO12
MW:
717.93
Mol File:
527-75-3.mol
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ERYTHROMYCIN B Chemical Properties

Melting point:
191-195 °C
Boiling point:
807.6±65.0 °C(Predicted)
Density 
1.17±0.1 g/cm3(Predicted)
solubility 
Chloroform (Slightly), Ethanol (Slightly), Ethyl Acetate (Slightly, Heated)
pka
13.49±0.70(Predicted)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
HS Code 
2941500000
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ERYTHROMYCIN B Usage And Synthesis

Uses

Erythromycin B is a co-metabolite of Erythromycin A (E649950), an antibacterial agent.

Uses

Erythromycin B (12-deoxyerythromycin A) is a minor co-metabolite of erythromycin produced Saccharopolyspora erythreae. Erythromycin B exhibits broad spectrum antibiotic activity, albeit less potent than erythromycin A. Erythromycin B played an integral part of the SAR studies of semi-synthetic erythromycins, however none reached clinical development.

Definition

ChEBI: Erythromycin B is an erythromycin that consists of erythronolide B having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attahced at positions 4 and 6 respectively. It is functionally related to an erythronolide B.

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