Cimifugin
Cimifugin Basic information
- Product Name:
- Cimifugin
- Synonyms:
-
- Cimifugin, 99.5%
- CIMIFUGIN(P)
- (2S)-7-(Hydroxymethyl)-2-(2-hydroxypropan-2-yl)-4-methoxy-2,3-dihydrofuro[3,2-g]chromen-5-one
- Cimifugin
- (S)-2,3-Dihydro-7-(hydroxymethyl)-2-(1-hydroxy-1-methylethyl)-4-methoxy-5H-furo[3,2-g][1]benzopyran-5-one
- CiMitin
- Cimifugin, 98%, from Saposhnikovia divaricata (Turcz.) Schischk.
- Cimifugin (Cimitin)
- CAS:
- 37921-38-3
- MF:
- C16H18O6
- MW:
- 306.31
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 37921-38-3.mol
Cimifugin Chemical Properties
- Melting point:
- 107～109℃
- Boiling point:
- 546.4±50.0 °C(Predicted)
- Density
- 1.361±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- pka
- 14.25±0.29(Predicted)
- form
- powder
- color
- White-beige
Cimifugin Usage And Synthesis
Components
The main components of Cimicifuga are triterpenoid polyoxygenates, chromogen ketones, phenolic acids, various chromones, odontoamol and odontoamicin. Among them, the identified structures are: isoferulic acid, 3-acetyl caffeic acid, caffeic ester glucoside, cimifugin, cimifugin glucoside, 6-isoxanthine nucleoside, cimidahurine, cimidahurinie, D-glucose, sucrose, etc.
Chemical Properties
Soluble in methanol, DMSO and other solvents, insoluble in petroleum ether. Sourced from the rhizome of Asclepias (Cimicifnga foetida L.)
Uses
Cimifugin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
- Siler Root
- Siler Root Dry Extract
- Siler Root Powder
Definition
ChEBI: Cimifugin is an oxacycle and an organic heterotricyclic compound.
in vivo
Cimifugin (Cimitin; 12.5 or 50 mg/kg/day; intragastrically; 2 days) significantly inhibits TSLP and IL-33 in the initial stage of Mice are sensitized and challenged with FITC to establish type 2 atopic dermatitis (AD) model. Simultaneously, Cimifugin reduces the separated gap among the epithelial cells and increased the expression of TJs[1].
target
IFN-γ | IL Receptor | AChE | BChE
CimifuginSupplier
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Cimifugin(37921-38-3)Related Product Information
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- Cimifugin
- Methoxy