2-(2-Aminoethyl)isothiourea dihydrobromide
2-(2-Aminoethyl)isothiourea dihydrobromide Basic information
- Product Name:
- 2-(2-Aminoethyl)isothiourea dihydrobromide
- Synonyms:
-
- s-(beta-aminoethyl)isothiuroniumbromidehydrobromide
- s-aminoethylisothiuroniumbromidehydrobromide
- s-beta-aminoethylisothiuroniumbromohydrate
- surrectan
- usafxr-31
- (2-aminoethyl)-2-thio-pseudouredihydrobromide
- 2-(2-aminoethyl)-2-thiopseudoureahydrobromide
- 2-(beta-aminoethyl)isothiouroniumbromidehydrobromide
- CAS:
- 56-10-0
- MF:
- C3H11Br2N3S
- MW:
- 281.01
- EINECS:
- 200-257-0
- Mol File:
- 56-10-0.mol
2-(2-Aminoethyl)isothiourea dihydrobromide Chemical Properties
- Melting point:
- 190-196 °C(lit.)
- Density
- 1.94 g/cm3
- storage temp.
- Store below +30°C.
- solubility
- 50g/l
- form
- powder to crystal
- color
- White to Almost white
- Water Solubility
- almost transparency
- Merck
- 14,178
- BRN
- 3911163
- CAS DataBase Reference
- 56-10-0(CAS DataBase Reference)
- EPA Substance Registry System
- Carbamimidothioic acid, 2-aminoethyl ester, dihydrobromide (56-10-0)
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36/37-22
- WGK Germany
- 3
- RTECS
- UM0175000
- F
- 10-21
- TSCA
- Yes
- HS Code
- 2930 90 98
- Toxicity
- LD50 in mice (mg/kg): 100 i.v., 280 s.c., 480 i.p., 1600 orally (Pospisil)
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
2-(2-Aminoethyl)isothiourea dihydrobromide Usage And Synthesis
?Synthesis
Ethylamine thiourea is synthesized by using cycloethylamine, hydrobromic acid and thiourea as raw materials: firstly, thiourea is mixed with hydrogen bromide acid, and cycloethylamine is added dropwise at a temperature below 150 °C. After the reaction is completed, add activated carbon to filter, and then reduce Dehydration under pressure, crystals are precipitated when the temperature is below 50°C, filtered, and washed twice with absolute ethanol.
Description
S-
Chemical Properties
Crystals, hygroscopic.
Uses
2-(2-Aminoethyl)isothiourea dihydrobromide inhibits nitric oxide synthase (NOS).
Uses
Has radioprotective activity against x-rays.
Uses
NOS inhibitor
Purification Methods
Crystallise the salt from absolute EtOH/ethyl acetate or MeOH. Store dry as it is hygroscopic in a humid atmosphere. It is a radioprotective agent. When refluxed in EtOH for 16hours or H2O for 30minutes, it decomposes to 2-amino-4(5H)-thiazoline hydrobromide which on recrystallisation from isoPrOH/EtOAc has m 175-176o [Doherty et al. J Am Chem Soc 79 5667 1957].
References
[1]. garvey ep, oplinger ja, tanoury gj, et al. potent and selective inhibition of human nitric oxide synthases. inhibition by non-amino acid isothioureas. j biol chem. 1994 oct 28;269(43):26669-76.
2-(2-Aminoethyl)isothiourea dihydrobromide Preparation Products And Raw materials
Raw materials
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2-(2-Aminoethyl)isothiourea dihydrobromide(56-10-0)Related Product Information
- N-Aminothiourea
- 1-PHENYL-2-THIOUREA
- 2-(2-Aminoethylamino)ethanol
- Dextromethorphan hydrobromide monohydrate
- Thiourea
- PHENAZINE ETHOSULFATE
- Allyl bromide
- Rocuronium bromide
- Galantamine Hydrobromide
- N,N'-Diethylthiourea
- N-Aminoethylpiperazine
- Ethylamine
- Hydrogen bromide
- Pyridine hydrobromide
- Sodium bromate
- Ethidium bromide
- Ethylamine hydrochloride
- Methyl bromide