Zenocutuzumab
Zenocutuzumab Basic information
- Product Name:
- Zenocutuzumab
- Synonyms:
-
- Zenocutuzumab
- Research Grade Zenocutuzumab (DHC09609)
- Research Grade Zenocutuzumab
- CAS:
- 1969309-56-5
- MW:
- 0
- Mol File:
- Mol File
More
Less
Zenocutuzumab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
More
Less
Zenocutuzumab Usage And Synthesis
Uses
Zenocutuzumab (MCLA-128) is a bispecific humanized IgG1 antibody containing two different Fab arms, targeting extracellular domains of HER2 and HER3[1].
in vivo
Zenocutuzumab (2.5-25 mg/kg; i.p.; once weekly; for 28 days) causes a statistically significant reduction of growth, including tumor regression[1].
| Animal Model: | 6 to 12-week-old female NSG? (LUAD-0061AS3), BALB/c nude (OV-10–0050) or athymic nude (ST2891, ST3204 and CTG-0953) mice injected with NRG1 fusion-positive patient-derived xenograft (PDX) tumors[1]. |
| Dosage: | 2.5 mg/kg, 8 mg/kg, or 25 mg/kg |
| Administration: | i.p.; once weekly; for 28 days |
| Result: | Blocked growth of lung and ovarian cancer PDX models. |
References
[1] Alison M Schram, et al. Zenocutuzumab, a HER2xHER3 Bispecific Antibody, Is Effective Therapy for Tumors Driven by NRG1 Gene Rearrangements. Cancer Discov. 2022 May 2;12(5):1233-1247. DOI:10.1158/2159-8290.CD-21-1119
ZenocutuzumabSupplier
ShangHai Biochempartner Co.,Ltd
- Tel
- 177-54423994 17754423994
- 2853530910@QQ.com
Wuhan Chemstan Biotechnology Co., Ltd.
- Tel
- 027-65317797 15926423062
- 422450190@qq.com
TargetMol Chemicals Inc.
- Tel
- 4008200310
- marketing@tsbiochem.com
Biolab Reagents
- Tel
- 027-65279366 18108604356
- products@biolabreagent.com
Wuhan Jingkangen Biomedical Technology Co., Ltd
- Tel
- 13720134139 086-15871494362 13720134139
- orders@jknbiochem.com