Ethyl 2-amino-5-bromothiazole-4-carboxylate
- Product Name
- Ethyl 2-amino-5-bromothiazole-4-carboxylate
- CAS No.
- 61830-21-5
- Chemical Name
- Ethyl 2-amino-5-bromothiazole-4-carboxylate
- Synonyms
- ethyl 2-a;Ethyl 2-amino-5-bromothiazole-4-carboxy;Ethyl 2-amino-5-bromothiazole-4-carboxylate;Ethyl 2-amino-5-bromo-4-thiazolecarboxylate;4-Ethyl 2-amino-5-bromothiazole-4-carboxylate;Ethyl 2-Amino-5-bromothiazole-4-carboxylicacid;2-Amino-5-bromo-4-(ethoxycarbonyl)-1,3-thiazole;ethyl 2-amino-5-bromo-1,3-thiazole-4-carboxylate;2-amino-5-bromthiazol-4-carbonic acid ethyl ester;2-AMINO-5-BROMOTHIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
- CBNumber
- CB0102119
- Molecular Formula
- C6H7BrN2O2S
- Formula Weight
- 251.1
- MOL File
- 61830-21-5.mol
Ethyl 2-amino-5-bromothiazole-4-carboxylate Property
- Melting point:
- 115-117 °C
- Boiling point:
- 357.0±22.0 °C(Predicted)
- Density
- 1.731±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- pka
- 0.88±0.10(Predicted)
- color
- brown
- CAS DataBase Reference
- 61830-21-5(CAS DataBase Reference)
Safety
- HazardClass
- IRRITANT
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E899413
- Product name
- Ethyl2-amino-5-bromothiazole-4-carboxylate
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 448854
- Product name
- Ethyl 2-amino-5-bromothiazole-4-carboxylate
- Packaging
- 100mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- OR2808
- Product name
- Ethyl2-amino-5-bromo-1,3-thiazole-4-carboxylate
- Packaging
- 100g
- Price
- $534
- Updated
- 2021/12/16
- Product number
- 057464
- Product name
- Ethyl 2-amino-5-bromothiazole-4-carboxylate
- Purity
- 99%
- Packaging
- 100g
- Price
- $559
- Updated
- 2021/12/16
- Product number
- OR2808
- Product name
- Ethyl2-amino-5-bromo-1,3-thiazole-4-carboxylate
- Packaging
- 5g
- Price
- $70
- Updated
- 2021/12/16
Ethyl 2-amino-5-bromothiazole-4-carboxylate Chemical Properties,Usage,Production
Uses
Ethyl 2-amino-5-bromothiazole-4-carboxylate is an organic synthetic reagent for the preparation of anticonvulsants.
Synthesis
5398-36-7
61830-21-5
GENERAL METHOD: Ethyl 2-aminothiazole-4-carboxylate (0.1 mol) was dissolved in a minimal amount of glacial acetic acid, and bromine (0.11 mol) was added drop-wise while stirring continuously at room temperature. The reaction mixture was heated at 80°C for 90 min followed by stirring at room temperature for 12 hrs. After completion of the reaction, the mixture was filtered and washed with deionized water. The resulting precipitate was dissolved in hot water, the aqueous solution was alkalized with ammonia, filtered again, the precipitate was washed with deionized water and finally dried. Recrystallization by mixed ethanol/water solvent gave ethyl 2-amino-5-bromo-4-thiazolecarboxylate (compounds 3a-f).
References
[1] Medicinal Chemistry Research, 2015, vol. 24, # 8, p. 3194 - 3211
[2] Journal of Medicinal Chemistry, 1977, vol. 20, p. 572 - 576
[3] Tetrahedron Letters, 2002, vol. 43, # 39, p. 7051 - 7053
[4] Patent: US2007/281979, 2007, A1. Location in patent: Page/Page column 22
[5] Patent: US2007/4700, 2007, A1. Location in patent: Page/Page column 23
Ethyl 2-amino-5-bromothiazole-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 2-amino-5-bromothiazole-4-carboxylate manufacturers
- Product
- Ethyl 2-amino-5-bromothiazole-4-carboxylate 61830-21-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-10
- Product
- Ethyl 2-amino-5-bromothiazole-4-carboxylate 61830-21-5
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- customise
- Release date
- 2018-08-09