ChemicalBook > CAS DataBase List > Ethyl 2-amino-5-bromothiazole-4-carboxylate

Ethyl 2-amino-5-bromothiazole-4-carboxylate

Product Name
Ethyl 2-amino-5-bromothiazole-4-carboxylate
CAS No.
61830-21-5
Chemical Name
Ethyl 2-amino-5-bromothiazole-4-carboxylate
Synonyms
ethyl 2-a;Ethyl 2-amino-5-bromothiazole-4-carboxy;Ethyl 2-amino-5-bromothiazole-4-carboxylate;Ethyl 2-amino-5-bromo-4-thiazolecarboxylate;4-Ethyl 2-amino-5-bromothiazole-4-carboxylate;Ethyl 2-Amino-5-bromothiazole-4-carboxylicacid;2-Amino-5-bromo-4-(ethoxycarbonyl)-1,3-thiazole;ethyl 2-amino-5-bromo-1,3-thiazole-4-carboxylate;2-amino-5-bromthiazol-4-carbonic acid ethyl ester;2-AMINO-5-BROMOTHIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
CBNumber
CB0102119
Molecular Formula
C6H7BrN2O2S
Formula Weight
251.1
MOL File
61830-21-5.mol
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Ethyl 2-amino-5-bromothiazole-4-carboxylate Property

Melting point:
115-117 °C
Boiling point:
357.0±22.0 °C(Predicted)
Density 
1.731±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
solid
pka
0.88±0.10(Predicted)
color 
brown
CAS DataBase Reference
61830-21-5(CAS DataBase Reference)
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Safety

HazardClass 
IRRITANT
HS Code 
2934100090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
E899413
Product name
Ethyl2-amino-5-bromothiazole-4-carboxylate
Packaging
500mg
Price
$65
Updated
2021/12/16
Usbiological
Product number
448854
Product name
Ethyl 2-amino-5-bromothiazole-4-carboxylate
Packaging
100mg
Price
$305
Updated
2021/12/16
Apolloscientific
Product number
OR2808
Product name
Ethyl2-amino-5-bromo-1,3-thiazole-4-carboxylate
Packaging
100g
Price
$534
Updated
2021/12/16
Matrix Scientific
Product number
057464
Product name
Ethyl 2-amino-5-bromothiazole-4-carboxylate
Purity
99%
Packaging
100g
Price
$559
Updated
2021/12/16
Apolloscientific
Product number
OR2808
Product name
Ethyl2-amino-5-bromo-1,3-thiazole-4-carboxylate
Packaging
5g
Price
$70
Updated
2021/12/16
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Ethyl 2-amino-5-bromothiazole-4-carboxylate Chemical Properties,Usage,Production

Uses

Ethyl 2-amino-5-bromothiazole-4-carboxylate is an organic synthetic reagent for the preparation of anticonvulsants.

Synthesis

5398-36-7

61830-21-5

GENERAL METHOD: Ethyl 2-aminothiazole-4-carboxylate (0.1 mol) was dissolved in a minimal amount of glacial acetic acid, and bromine (0.11 mol) was added drop-wise while stirring continuously at room temperature. The reaction mixture was heated at 80°C for 90 min followed by stirring at room temperature for 12 hrs. After completion of the reaction, the mixture was filtered and washed with deionized water. The resulting precipitate was dissolved in hot water, the aqueous solution was alkalized with ammonia, filtered again, the precipitate was washed with deionized water and finally dried. Recrystallization by mixed ethanol/water solvent gave ethyl 2-amino-5-bromo-4-thiazolecarboxylate (compounds 3a-f).

References

[1] Medicinal Chemistry Research, 2015, vol. 24, # 8, p. 3194 - 3211
[2] Journal of Medicinal Chemistry, 1977, vol. 20, p. 572 - 576
[3] Tetrahedron Letters, 2002, vol. 43, # 39, p. 7051 - 7053
[4] Patent: US2007/281979, 2007, A1. Location in patent: Page/Page column 22
[5] Patent: US2007/4700, 2007, A1. Location in patent: Page/Page column 23

Ethyl 2-amino-5-bromothiazole-4-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 2-amino-5-bromothiazole-4-carboxylate Suppliers

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View Lastest Price from Ethyl 2-amino-5-bromothiazole-4-carboxylate manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Ethyl 2-amino-5-bromothiazole-4-carboxylate 61830-21-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-10
Career Henan Chemical Co
Product
Ethyl 2-amino-5-bromothiazole-4-carboxylate 61830-21-5
Price
US $2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
customise
Release date
2018-08-09

61830-21-5, Ethyl 2-amino-5-bromothiazole-4-carboxylateRelated Search:

ISOXADIFEN-ETHYL 2-Amino-5-bromobenzothiazole 4-Thiazolecarboxylic acid Trinexapac-ethyl Benzocaine 2-(2-Aminothiazol-4-yl)glyoxylic acid Tris(trimethylsilyl)phosphate Methyl acrylate 6-Aminocaproic acid RESMETHRIN Ethyl cyanoacetate Ethyl acrylate Ethyl propiolate Ethanol Urethane Ethyl formate Ethylparaben Ethyl acetate

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