2-Methoxybenzoic acid
- Product Name
- 2-Methoxybenzoic acid
- CAS No.
- 529-75-9
- Chemical Name
- 2-Methoxybenzoic acid
- Synonyms
- 2-Methoxybenzoic acid;2-METHYOXY BENZOICACID;2-Methoxylbenzoic acid;2-METHOXYBENZOIC ACID 529-75-9
- CBNumber
- CB01075874
- Molecular Formula
- C8H8O3
- Formula Weight
- 152.15
- MOL File
- 529-75-9.mol
2-Methoxybenzoic acid Property
- Melting point:
- 101-103oC
- Boiling point:
- 182-185 °C (lit.)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Sparingly), Methanol (Sparingly)
- pka
- 4.08(at 25℃)
- form
- Solid
- color
- White to Off-White
- JECFA Number
- 881
- InChI
- InChI=1S/C8H8O3/c1-11-7-5-3-2-4-6(7)8(9)10/h2-5H,1H3,(H,9,10)
- InChIKey
- ILUJQPXNXACGAN-UHFFFAOYSA-N
- SMILES
- C1(OC)C=CC=CC=1C(=O)O
2-Methoxybenzoic acid Chemical Properties,Usage,Production
Description
2-Methoxybenzoic acid, also called 2-methoxybenzoate or O-anisic acid, belongs to a group of organic compounds called o-methoxybenzoic acids. These compounds have a methoxy group substituted for the hydrogen atom at position 2 of the benzene ring. In its solid form, 2-methoxybenzoic acid is slightly soluble in water and has weak acidity (indicated by its pKa value). It has been found in various biofluids and s primarily located in the cytoplasm of cells. Additionally, it can be converted into cyprosulfamide. 2-methoxybenzoic acid is present in foods like jew's ear, muscadine grape, sesame, and elliott's blueberry. Therefore, it can potentially be used as a biomarker for the consumption of these food products.
Uses
2-Methoxybenzoic Acid is used in the preparation of benzohydroxamic acids as potent and selective anti-hepatitis C virus (HCV) agents.
Definition
ChEBI: O-methylsalicylic acid is a methoxybenzoic acid that is the methyl ether of salicylic acid. It has a role as a non-steroidal anti-inflammatory drug and a flavouring agent. It is a conjugate acid of an O-methylsalicylate.
Preparation
The synthesis of 2-methoxybenzoic acid involved dissolving 0.8 kg (20 mol) of sodium hydroxide into 4.7 L of water in a 15 L glass reaction kettle, which was then stirred. The temperature of the reaction kettle was lowered to 0 °C using a low-temperature cycle device. Next, 1.38 kg (10 mol) of salicylic acid was added to the solution and stirred until completely dissolved.
Afterward, 1 L (10.5 mol) of dimethyl sulfate was added to the solution and stirred for 30 minutes at 0 °C. The reaction liquid was then heated to 35 °C for 30 minutes, followed by the sequential addition of 1 L (10.5 mol) of dimethyl sulfate. The temperature was further increased to 45 °C and maintained for 1.0 hour. The mixed solution was then heated to reflux for 2.0 hours.
To adjust the pH of the solution, 40% sodium hydroxide was added until it reached a value of 10. The solution continued to reflux for another 2.0 hours and was naturally cooled to room temperature. Subsequently, hydrochloric acid was used to adjust the pH to 1, resulting in the formation of a significant amount of white precipitate after stirring for 30 minutes.
The final product, 2-methoxybenzoic acid, was obtained by washing and drying the precipitate in an oven, yielding 1.4 kg.
Application
2-Methoxybenzoic acid, also known as 2-methoxybenzoate or O-anisic acid, belongs to the class of organic compounds known as o-methoxybenzoic acids and derivatives. These are benzoic acids in which the hydrogen atom at position 2 of the benzene ring is replaced by a methoxy group. 2-Methoxybenzoic acid has been detected, but not quantified in, several different foods, such as sugar apples (Annona squamosa), cereals and cereal products, fruits, cowpeas (Vigna unguiculata), and other cereal products. This could make 2-methoxybenzoic acid a potential biomarker for the consumption of these foods.
Synthesis Reference(s)
Tetrahedron Letters, 22, p. 1013, 1981 DOI: 10.1016/S0040-4039(01)82853-7
Solubility in water
The water solubility was determined to be 5443.79 mg/L at 30°C.
2-Methoxybenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-Methoxybenzoic acid Suppliers
- Tel
- 13305392349; 15269100373
- Fax
- 0539-7910696
- 977495915@qq.com
- Country
- China
- ProdList
- 491
- Advantage
- 58
- Tel
- 0536-8888106 17663601818
- Fax
- 0536-8888106
- 2354379876@qq.com
- Country
- China
- ProdList
- 244
- Advantage
- 58
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- sales@capotchem.com
- Country
- China
- ProdList
- 18217
- Advantage
- 66
- Tel
- 021-54306202 13764082696;
- info@hanhongsci.com
- Country
- China
- ProdList
- 42982
- Advantage
- 64
- Tel
- 400-1166-196 18981987031
- Fax
- 028-84555506 800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 11726
- Advantage
- 57
- Tel
- Please Send Email 18652950785
- Fax
- 025-87193546
- chemweiao@163.com
- Country
- China
- ProdList
- 4388
- Advantage
- 65
- Tel
- 0370-2785118 15343847665
- Fax
- QQ：3470079902
- huawenchem@163.com
- Country
- China
- ProdList
- 3206
- Advantage
- 55
- Tel
- 4008-755-333 18080918076
- Fax
- 028-86757656
- 800078821@qq.com
- Country
- China
- ProdList
- 9725
- Advantage
- 55
- Tel
- 0512-65617459 18915409046
- Fax
- 0512-65617459
- sales@sibian-chem.com
- Country
- China
- ProdList
- 1927
- Advantage
- 55
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9452
- Advantage
- 58
- Tel
- 86-13605431940 13605431940
- Fax
- 0086-0543-2240079
- zpmxchemical@126.com
- Country
- China
- ProdList
- 2002
- Advantage
- 62
- Tel
- 86-21-51086038
- Fax
- 86-21-51861608
- Country
- China
- ProdList
- 2931
- Advantage
- 58
- Tel
- 400-1166-196 13458535857
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 13358
- Advantage
- 58
- Tel
- 15221275939 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 15878
- Advantage
- 55
- Tel
- 010-1234567 18521000990
- Fax
- 86-021-33275113
- sonyuanchemical@163.com
- Country
- China
- ProdList
- 6490
- Advantage
- 50
- Tel
- 13096311329 028-88469284 616445927
- Fax
- 028-88469284
- 616445927@qq.com
- Country
- China
- ProdList
- 2876
- Advantage
- 50
- Tel
- 025-87193546 18652950785
- Fax
- 025-87193546
- chemweiao@163.com
- Country
- China
- ProdList
- 9030
- Advantage
- 60
- Tel
- 021-50908862，442785678，326799392 18721037013
- Fax
- 021-50908862
- siyansales@126.com
- Country
- China
- ProdList
- 9638
- Advantage
- 58
- Tel
- 400-1166-196 18502815961
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 14623
- Advantage
- 60
- Tel
- QQ:65489617 15618227136
- Fax
- 21-5161 9052
- info@SuperLan-chem.com
- Country
- China
- ProdList
- 9445
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131981
- Advantage
- 58
- Tel
- 0751-2886750 13927877953
- Fax
- 0751-2886750
- 3005811397@qq.com
- Country
- China
- ProdList
- 13352
- Advantage
- 58
- Tel
- 17721395025
- Fax
- 021-68882955
- 2423903095@qq.com
- Country
- China
- ProdList
- 3150
- Advantage
- 58
- Tel
- 027-65526929 15102793023
- Fax
- 027-65526669
- hbhxry@163.com
- Country
- China
- ProdList
- 2060
- Advantage
- 55
- Tel
- 18800375331
- Fax
- 021-50908862
- kangmansales@163.com
- Country
- China
- ProdList
- 7580
- Advantage
- 55
- Tel
- 13661490451 13671802554
- Fax
- QQ627235036
- xyfn@163.com
- Country
- China
- ProdList
- 582
- Advantage
- 58
- Tel
- 0531-68657833 15553112864
- Fax
- -
- 2098511197@qq.com
- Country
- China
- ProdList
- 221
- Advantage
- 58
- Tel
- 571-85586718 +8613336195806
- Fax
- +86-571-85864795
- sales@capotchem.com
- Country
- China
- ProdList
- 29797
- Advantage
- 60
- Tel
- 027-87466105 15377573527
- 2678564200@qq.com
- Country
- China
- ProdList
- 17997
- Advantage
- 58
- Tel
- 400-400-1332688 18019345275
- Fax
- 400-133-2688
- amy@rhawn.cn
- Country
- China
- ProdList
- 15503
- Advantage
- 58
- Tel
- 021-60345187 13917602471
- Fax
- 021-60345187
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 9908
- Advantage
- 58
- Tel
- 027-51831887 15337167856
- Fax
- 027-51837635 QQ1165326703
- hubeixinyuanshun@163.com
- Country
- China
- ProdList
- 10305
- Advantage
- 58
- Tel
- 13382066392
- Country
- CHINA
- ProdList
- 4880
- Advantage
- 58
- Tel
- 0371-0371-63315541 13323832564
- Fax
- QQ:3001332135
- 3001332135@qq.com
- Country
- China
- ProdList
- 8820
- Advantage
- 58
- Tel
- +86-0710-4323688 +86-18071785587
- Fax
- 15502706050
- market@yxinchem.com
- Country
- China
- ProdList
- 1022
- Advantage
- 58
- Tel
- 18019463053
- Fax
- 021-50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 13017
- Advantage
- 58
- Tel
- 15926260361
- Fax
- QQ:1930063008
- 1930063008@qq.com
- Country
- China
- ProdList
- 5094
- Advantage
- 58
- Tel
- 025-58351158 13851454004
- Fax
- 025-83271564
- 3494688757@qq.com
- Country
- China
- ProdList
- 116
- Advantage
- 58
- Tel
- 0571-0571-87682782 18957127338
- Fax
- QQ800182836
- sales@zetchem.com
- Country
- China
- ProdList
- 573
- Advantage
- 58
- Tel
- 027-83855389 13545340383
- Fax
- 027-83855389
- 2586905842@qq.com
- Country
- China
- ProdList
- 1246
- Advantage
- 58
- Tel
- +8617531190177
- peter@yan-xi.com
- Country
- China
- ProdList
- 5993
- Advantage
- 58
- Tel
- +8618339805032
- alfa4@alfachem.cn
- Country
- China
- ProdList
- 12755
- Advantage
- 58
- Tel
- +862156762820 +86-13564624040
- sales@myuchem.com
- Country
- China
- ProdList
- 6710
- Advantage
- 58
- Tel
- +8613288715578
- sales@hbmojin.com
- Country
- China
- ProdList
- 12459
- Advantage
- 58
- Tel
- 0551-65418671
- Fax
- 0551-65418697
- sales@tnjchem.com
- Country
- China
- ProdList
- 34572
- Advantage
- 58
- Tel
- +8618330912755
- Fax
- +8619932103556
- sale2@hbyalin.com
- Country
- China
- ProdList
- 1677
- Advantage
- 58
- Tel
- +8615986615575
- Fax
- 0086-13651442114
- info@codchem.com
- Country
- China
- ProdList
- 20356
- Advantage
- 58
- Tel
- 571-88938639 +8617705817739
- Fax
- +86-571-88938652，+86-571- 88492614
- info@dycnchem.com
- Country
- CHINA
- ProdList
- 52867
- Advantage
- 58
- Tel
- +8615604608665 15604608665
- dominicguo@gk-bio.com
- Country
- CHINA
- ProdList
- 9427
- Advantage
- 58
- Tel
- 0571-85134551
- Fax
- 008657185134895
- info@afinechem.com
- Country
- CHINA
- ProdList
- 15377
- Advantage
- 58
View Lastest Price from 2-Methoxybenzoic acid manufacturers
- Product
- 2-Methoxybenzoic Acid 529-75-9
- Price
- US $0.00-0.00/kgkg
- Min. Order
- 1kgkg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2024-04-15
- Product
- 2-Methoxybenzoic acid 529-75-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2022-10-27
- Product
- 2-Methoxybenzoic acid 529-75-9
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2023-09-08