3-Amino-2,2-dimethylpropionamide
- Product Name
- 3-Amino-2,2-dimethylpropionamide
- CAS No.
- 324763-51-1
- Chemical Name
- 3-Amino-2,2-dimethylpropionamide
- Synonyms
- Aliskiren Inter-5;3-aMino-2,2-diMethyl-;ALISKIREN InterMediates/ AM4;3-Amino-2,2-dimethylpropiomide;3-AMino-2,2-diMethylpropinaMid;3-Amino-2,2-dimethylpropanamide;3-Amino-2,2-dimethylpropionamide;PropanaMide, 3-aMino-2,2-diMethyl-;2-(aminomethyl)-2-methylpropanamide;3-amino-2,2-dimethylpropionic acid amide
- CBNumber
- CB01094136
- Molecular Formula
- C5H12N2O
- Formula Weight
- 116.16
- MOL File
- 324763-51-1.mol
3-Amino-2,2-dimethylpropionamide Property
- Melting point:
- 74-75 °C
- Boiling point:
- 271 °C
- Density
- 1.004
- Flash point:
- 117 °C
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO, Methanol
- pka
- 16.45±0.50(Predicted)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C5H12N2O/c1-5(2,3-6)4(7)8/h3,6H2,1-2H3,(H2,7,8)
- InChIKey
- HKQZJXVIXAPOPZ-UHFFFAOYSA-N
- SMILES
- C(N)(=O)C(C)(C)CN
- CAS DataBase Reference
- 324763-51-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- A607370
- Product name
- 3-Amino-2,2-dimethylpropanamide
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- A607370
- Product name
- 3-Amino-2,2-dimethylpropanamide
- Packaging
- 5G
- Price
- $450
- Updated
- 2021/12/16
- Product number
- CHM0069273
- Product name
- 3-AMINO-2,2-DIMETHYLPROPIONAMIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $867.1
- Updated
- 2021/12/16
- Product number
- CHM0069273
- Product name
- 3-AMINO-2,2-DIMETHYLPROPIONAMIDE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1255.54
- Updated
- 2021/12/16
- Product number
- CHM0069273
- Product name
- 3-AMINO-2,2-DIMETHYLPROPIONAMIDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1590.46
- Updated
- 2021/12/16
3-Amino-2,2-dimethylpropionamide Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
3-Amino-2,2-dimethylpropionamide is a kind of Reagent, used in the synthesis of Aliskiren.
Synthesis
7505-93-3
324763-51-1
The general procedure for the synthesis of 3-amino-2,2-dimethylpropionamide from 2-cyano-2-methylpropionamide is as follows: embodiment 5 (according to the present invention) Preparation of 3-amino-2,2-dimethylpropionamide: The product of embodiment 4 was dissolved in 840 mL of methanol-ammonia mixture (containing 169 g NH3/kg), which was subsequently transferred to an autoclave. To this was added 47.9 g of Raney Ni catalyst. The reaction mixture was stirred for hydrogenation at 60-70 °C and 5 bar hydrogen pressure for 10 hours. When analysis confirmed that the feedstock was completely consumed, the reaction mixture was filtered, the filter cake was washed with methanol, and the filtrate was subsequently evaporated to give 160 g (97% yield) of crude product. The crude product was dissolved in 800 mL of isopropanol-toluene (1:9, v/v) mixed solvent for recrystallization. Finally, 124 g (78% overall yield) of the target product 3-amino-2,2-dimethylpropionamide was obtained.
References
[1] Patent: WO2012/21446, 2012, A2. Location in patent: Page/Page column 30-31
[2] Patent: WO2010/112482, 2010, A1. Location in patent: Page/Page column 29
[3] Tetrahedron Letters, 2005, vol. 46, # 37, p. 6337 - 6340
[4] Patent: WO2011/148392, 2011, A1. Location in patent: Page/Page column 64
[5] Journal of Medicinal Chemistry, 2017, vol. 60, # 3, p. 957 - 971
3-Amino-2,2-dimethylpropionamide Preparation Products And Raw materials
Raw materials
Preparation Products
3-Amino-2,2-dimethylpropionamide Suppliers
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View Lastest Price from 3-Amino-2,2-dimethylpropionamide manufacturers
- Product
- 3-Amino-2,2-dimethylpropionamide 324763-51-1
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2024-08-08
- Product
- 3-Amino-2,2-dimethylpropionamide 324763-51-1
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-18
- Product
- 3-Amino-2,2-dimethylpropionamide 324763-51-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-18