ChemicalBook > CAS DataBase List > (6-Methylpyridin-3-yl)methanol
(6-Methylpyridin-3-yl)methanol
- Product Name
- (6-Methylpyridin-3-yl)methanol
- CAS No.
- 34107-46-5
- Chemical Name
- (6-Methylpyridin-3-yl)methanol
- Synonyms
- 5-Hydroxymethyl-2-picoline;6-Methylpyridine-3-methanol;6-Methyl-3-PyridineMethanol;(6-Methyl-3-pyridyl)methanol;6-(Methylpyridin-3-yl)methano;3-Pyridinemethanol, 6-methyl-;(6-methyl-3-pyridinyl)methanol;6-Methyl-3-pyridinemethanol >5-Hyroxymethyl-2-methylpyridine;5-(Hydroxymethyl)-2-methylpyridine
- CBNumber
- CB01263042
- Molecular Formula
- C7H9NO
- Formula Weight
- 123.15
- MOL File
- 34107-46-5.mol
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(6-Methylpyridin-3-yl)methanol Property
- Melting point:
- 43-47 °C
- Boiling point:
- 100°C/0.7mmHg(lit.)
- Density
- 1.092±0.06 g/cm3(Predicted)
- refractive index
- n20/D 1.540
- Flash point:
- >110°C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- soluble in Methanol
- form
- Solid
- pka
- 13.70±0.10(Predicted)
- color
- White
- InChI
- InChI=1S/C7H9NO/c1-6-2-3-7(5-9)4-8-6/h2-4,9H,5H2,1H3
- InChIKey
- DJCJOWDAAZEMCI-UHFFFAOYSA-N
- SMILES
- C1=NC(C)=CC=C1CO
- CAS DataBase Reference
- 34107-46-5
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Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2933399990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 716367
- Product name
- 5-Hydroxymethyl-2-methylpyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $77.6
- Updated
- 2023/06/20
TCI Chemical
- Product number
- M2683
- Product name
- 6-Methyl-3-pyridinemethanol
- Purity
- >97.0%(GC)(T)
- Packaging
- 1g
- Price
- $34
- Updated
- 2025/07/31
TCI Chemical
- Product number
- M2683
- Product name
- 6-Methyl-3-pyridinemethanol
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $101
- Updated
- 2025/07/31
Usbiological
- Product number
- 161920
- Product name
- 5-Hydroxymethyl-2-methylpyridine
- Packaging
- 250mg
- Price
- $460
- Updated
- 2021/12/16
TRC
- Product number
- H947980
- Product name
- 5-Hydroxymethyl-2-methylpyridine
- Packaging
- 2.5g
- Price
- $1260
- Updated
- 2021/12/16
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(6-Methylpyridin-3-yl)methanol Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
5-Hydroxymethyl-2-methylpyridine is a reactant used in the preparation of pioglitazone (P471000) metabolites.
Uses
(6-Methylpyridin-3-yl)methanol is a reactant used in the preparation of pioglitazone (P471000) metabolites.
Synthesis
5470-70-2
34107-46-5
General procedure for the synthesis of 6-methyl-3-methanolpyridine from 6-methylnicotinic acid methyl ester: To a stirred solution of 6-methylnicotinic acid methyl ester (21 g; 140 mmol; 1 eq.) in anhydrous THF (150 mL) was added slowly and dropwise to a THF solution (210 mL; 210 mmol; 1.5 eq.) of 1 M LiAlH4 at -5 °C. After the dropwise addition, the reaction mixture was continued to be stirred at 23 °C for 2 hours. Subsequently, the mixture was cooled to -10 °C and the reaction was carefully quenched with sodium sulfate decahydrate and ethyl acetate until bubbling ceased. The mixture was filtered through a pad of diatomaceous earth and the filtrate was concentrated to dryness under reduced pressure to afford 6-methyl-3-methanolpyridine (17 g, 100% yield). The product was characterized by 1H NMR (DMSO-d6): δ 8.37 (s, 1H), 7.59 (dd, 1H, J = 2,8Hz), 7.19 (d, 1H, J = 8Hz), 5.22 (t, 1H, J = 6Hz), 4.47 (d, 2H, J = 6Hz), 2.45 (s, 3H).
References
[1] Patent: WO2015/95128, 2015, A1. Location in patent: Paragraph 0152; 0155; 0156
[2] Organic Preparations and Procedures International, 2015, vol. 47, # 3, p. 220 - 226
[3] Patent: US2005/124586, 2005, A1. Location in patent: Page/Page column 7
[4] Journal of the Chemical Society. Perkin Transactions 2, 2002, # 5, p. 928 - 937
[5] Patent: WO2018/165718, 2018, A1. Location in patent: Page/Page column 100; 101; 102
(6-Methylpyridin-3-yl)methanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (6-Methylpyridin-3-yl)methanol manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- (6-Methylpyridin-3-yl)methanol 34107-46-5
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-08-02
Zibo Shiji Zhonglian Medical Technology Co., Ltd.
- Product
- (6-Methylpyridin-3-yl)methanol 34107-46-5
- Price
- US $1.00/KG
- Min. Order
- 25KG
- Purity
- 99.0%
- Supply Ability
- 5000KG/th
- Release date
- 2023-06-14
Dideu Industries Group Limited
- Product
- (6-Methylpyridin-3-yl)methanol 34107-46-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-27
34107-46-5, (6-Methylpyridin-3-yl)methanolRelated Search:
2-Hydroxy-6-methylpyridine-3-carboxylic acid
2,5-PYRIDINEDICARBOXYLIC ACID
Pyridoxal hydrochloride
Pyridoxine
6-Methylpyridine-3-carboxylic acid
Methyl 6-methylnicotinate
DIETHYL 2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE
4-Deoxypyridoxine hydrochloride
2,5-PYRIDINEDICARBOXYLIC ACID DI-N-PROPYL ESTER
Pyridoxamine dihydrochloride
DIMETHYL PYRIDINE-2,5-DICARBOXYLATE
Pyridoxine hydrochloride
4-Pyridoxic acid
Pyridoxal 5'-phosphate monohydrate
PYRIDOXYLIDENE-L-ISOLEUCINE POTASSIUM SALT
PYRIDOXAMINE-5'-PHOSPHATE
4-deoxypyridoxine
2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID