Sofalcone

ChemicalBook > CAS DataBase List > Sofalcone

Pharmacological action Pharmacokinetics

Product Name: Sofalcone
CAS No.: 64506-49-6
Chemical Name: Sofalcone
Synonyms: su88;solon;Sofacone;SOFALCONE;SOFALCONE JP;Mr. Method ketone;isoprenylchalcone;Sofalcone USP/EP/BP;SOFALCONE MICROPOWDER;l)-1-oxo-2-propenyl)phenoxy)-
CBNumber: CB0143037
Molecular Formula: C27H30O6
Formula Weight: 450.52
MOL File: 64506-49-6.mol

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Sofalcone Property

Melting point:: 143-144°
Boiling point:: 478.6°C (rough estimate)
Density: 1.1362 (rough estimate)
refractive index: 1.4870 (estimate)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Solid
pka: 2.98±0.10(Predicted)
color: Light Yellow
CAS DataBase Reference: 64506-49-6(CAS DataBase Reference)

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Safety

Toxicity: LD50 in mice, rats: >10 g/kg orally (Tarumoto)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11882
Product name: Sofalcone
Purity: ≥98%
Packaging: 100mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 11882
Product name: Sofalcone
Purity: ≥98%
Packaging: 250mg
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 11882
Product name: Sofalcone
Purity: ≥98%
Packaging: 500mg
Price: $216
Updated: 2024/03/01

TRC

Product number: S675500
Product name: Sofalcone
Packaging: 2g
Price: $225
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FS27851
Product name: Sofalcone
Packaging: 500mg
Price: $90
Updated: 2021/12/16

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Sofalcone Chemical Properties,Usage,Production

Pharmacological action

Sofalcone is an effective component extracted and synthesized from traditional Chinese medicine Sophora tonkinensis. It is the product of isoprene derivatives. It can increase gastric blood flow, expand gastric mucosal blood vessels, increase oxygen consumption in gastric tissue, promote gastric mucosal repair, increase gastric wall composition and increase prostaglandin content in gastric tissue. Its mechanism is to inhibit prostaglandin 5hydroxyl prostaglandin dehydrogenase (PG). This product has a good effect on the ulcer of the digestive tract by enhancing the defense factor. It is mainly used for the treatment of gastric ulcer and gastritis.

Figure 1 Structural formula for sofalcone

Pharmacokinetics

This product is absorbed quickly after oral administration, and the concentration is up to the peak in about one hour. The half life of plasma is about 1h, and it will almost disappear in the blood after 2h. The main metabolites in the body are the reductive products of the alpha and beta unsaturated bonds of the chalcone skeleton, and the oxidation products of the isoprene side chain. It is excreted from urine by 6% to 8% in the form of isoprene chain oxidation products within 48h.

Description

Sofalcone is a synthetic antiulcer agent related to sophoradin, the active principle of the Chinese medicinal plant, Sophora subprostata. It is suggested to act via a strengthening of the mucosal barrier through an increase in blood flow and stimulation of the synthesis of sulfated mucopolysaccharides.

Originator

Japan (Japan)

Uses

Sofalcone is an anti-ulcer chalcone derivative. It blocks inflammation by suppressing the production of nitric oxide, TNF-α, and MCP-1 while inducing the expression of heme oxygenase-1 when used at 10-20 μM. Sofalcone (20-50 μM) induces VEGF expression in gastric epithelial cells and promotes gastric ulcer healing following eradication therapy for H. pylori.[Cayman Chemical]

Uses

Sofalcone is a substituted chalcone with anti-ulcer activity.

Definition

ChEBI: Sofalcone is a member of the class of chalcones that is benzene in which the hydrogens at positions 1,2 and 5 are replaced by carboxymethoxy, (1E)-1-{4-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-oxoprop-1-en-3-yl, and (3-methylbut-2-en-1-yl)oxy groups, respectively. It is a gastrointestinal drug currently used for treatment of gastritis and gastric ulcers in Japan and South Korea. It has a role as an anti-ulcer drug, a gastrointestinal drug, a plant metabolite and an antibacterial agent. It is an aromatic ether, a monocarboxylic acid and a member of chalcones.

Sofalcone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Sofalcone manufacturers

Hebei Duling International Trade Co. LTD

Product: Sofalcone 64506-49-6
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 Ton
Release date: 2023-02-23

Shaanxi Dideu Medichem Co. Ltd

Product: Sofalcone 64506-49-6
Price: US $1.00-1.00/Kg/Bag
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-04-30

Hebei Shengyuan Jinlong Import and Export Co. LTD

Product: Sofalcone 64506-49-6
Price: US $100.00-50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: Monthly supply of 1 ton
Release date: 2022-10-28

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{5-[(3-methyl-2-butenyl)oxy]-2-{p-[(3-methyl-2-butenyl)oxy]cinnamoyl}phenoxy}acetic acid

SOFALCONE

SOFALCONE(2'-ETHOXYCARBONYLMETHOXY-4'-(3-METHYL-2-BUTENYL-OXY)ACETOPHENONE)

SOFALCONE JP

SOFALCONE MICROPOWDER

[4,4'-Bis(3-methyl-2-butenyloxy)chalcon-2'-yloxy]acetic acid

[5-[(3-Methyl-2-butenyl)oxy]-2-[3-[4-[(3-methyl-2-butenyl)oxy]phenyl]-1-oxo-2-propenyl]phenoxy]acetic acid

2-[5-[(3-Methyl-2-buten-1-yl)oxy]-2-[3-[4-[(3-Methyl-2-buten-1-yl)oxy]phenyl]-1-oxo-2-propen-1-yl]phenoxy]acetic Acid

Mr. Method ketone

2-[5-(3-methylbut-2-enoxy)-2-[(E)-3-[4-(3-methylbut-2-enoxy)phenyl]-1-oxoprop-2-enyl]phenoxy]acetic acid

2’-carboxymethoxy-4,4’-bis(3-methyl-2-butenyloxy)chalcone

aceticacid,(5((3-methyl-2-butenyl)oxy)-2-(3-(4-((3-methyl-2-butenyl)oxy)pheny

isoprenylchalcone

l)-1-oxo-2-propenyl)phenoxy)-

solon

su88

Acetic acid, 2-[5-[(3-methyl-2-buten-1-yl)oxy]-2-[3-[4-[(3-methyl-2-buten-1-yl)oxy]phenyl]-1-oxo-2-propen-1-yl]phenoxy]-

Sofalcone USP/EP/BP

2-(5-((3-Methylbut-2-en-1-yl)oxy)-2-(3-(4-((3-methylbut-2-en-1-yl)oxy)phenyl)acryloyl)phenoxy)acetic acid

Sofacone

64506-49-6

4506-49-6

506-49-6

C27H30O6