Pharmacological action Pharmacokinetics
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Sofalcone

Pharmacological action Pharmacokinetics
Product Name
Sofalcone
CAS No.
64506-49-6
Chemical Name
Sofalcone
Synonyms
su88;solon;Sofacone;SOFALCONE;SOFALCONE JP;(E)-Sofalcone;Mr. Method ketone;isoprenylchalcone;Sofalcone USP/EP/BP;SOFALCONE MICROPOWDER
CBNumber
CB0143037
Molecular Formula
C27H30O6
Formula Weight
450.52
MOL File
64506-49-6.mol
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Sofalcone Property

Melting point:
143-144°
Boiling point:
478.6°C (rough estimate)
Density 
1.1362 (rough estimate)
refractive index 
1.4870 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
Solid
pka
2.98±0.10(Predicted)
color 
Light Yellow
CAS DataBase Reference
64506-49-6(CAS DataBase Reference)
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Safety

Toxicity
LD50 in mice, rats: >10 g/kg orally (Tarumoto)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11882
Product name
Sofalcone
Purity
≥98%
Packaging
100mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
11882
Product name
Sofalcone
Purity
≥98%
Packaging
250mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
11882
Product name
Sofalcone
Purity
≥98%
Packaging
500mg
Price
$216
Updated
2024/03/01
TRC
Product number
S675500
Product name
Sofalcone
Packaging
2g
Price
$225
Updated
2021/12/16
Biosynth Carbosynth
Product number
FS27851
Product name
Sofalcone
Packaging
500mg
Price
$90
Updated
2021/12/16
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Sofalcone Chemical Properties,Usage,Production

Pharmacological action

Sofalcone is an effective component extracted and synthesized from traditional Chinese medicine Sophora tonkinensis. It is the product of isoprene derivatives. It can increase gastric blood flow, expand gastric mucosal blood vessels, increase oxygen consumption in gastric tissue, promote gastric mucosal repair, increase gastric wall composition and increase prostaglandin content in gastric tissue. Its mechanism is to inhibit prostaglandin 5hydroxyl prostaglandin dehydrogenase (PG). This product has a good effect on the ulcer of the digestive tract by enhancing the defense factor. It is mainly used for the treatment of gastric ulcer and gastritis.

Figure 1 Structural formula for sofalcone

Pharmacokinetics

This product is absorbed quickly after oral administration, and the concentration is up to the peak in about one hour. The half life of plasma is about 1h, and it will almost disappear in the blood after 2h. The main metabolites in the body are the reductive products of the alpha and beta unsaturated bonds of the chalcone skeleton, and the oxidation products of the isoprene side chain. It is excreted from urine by 6% to 8% in the form of isoprene chain oxidation products within 48h.

Description

Sofalcone is a synthetic antiulcer agent related to sophoradin, the active principle of the Chinese medicinal plant, Sophora subprostata. It is suggested to act via a strengthening of the mucosal barrier through an increase in blood flow and stimulation of the synthesis of sulfated mucopolysaccharides.

Originator

Japan (Japan)

Uses

Sofalcone is an anti-ulcer chalcone derivative. It blocks inflammation by suppressing the production of nitric oxide, TNF-α, and MCP-1 while inducing the expression of heme oxygenase-1 when used at 10-20 μM. Sofalcone (20-50 μM) induces VEGF expression in gastric epithelial cells and promotes gastric ulcer healing following eradication therapy for H. pylori.[Cayman Chemical]

Uses

Sofalcone is a substituted chalcone with anti-ulcer activity.

Definition

ChEBI: Sofalcone is a member of the class of chalcones that is benzene in which the hydrogens at positions 1,2 and 5 are replaced by carboxymethoxy, (1E)-1-{4-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-oxoprop-1-en-3-yl, and (3-methylbut-2-en-1-yl)oxy groups, respectively. It is a gastrointestinal drug currently used for treatment of gastritis and gastric ulcers in Japan and South Korea. It has a role as an anti-ulcer drug, a gastrointestinal drug, a plant metabolite and an antibacterial agent. It is an aromatic ether, a monocarboxylic acid and a member of chalcones.

Sofalcone Preparation Products And Raw materials

Raw materials

Preparation Products

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Sofalcone Suppliers

ecochem international chemical broker
Tel
--
Fax
--
Email
export@ecochem.dk
Country
Europe
ProdList
6371
Advantage
66
kemikalieimport
Tel
--
Fax
--
Email
Sales@kemikalieimport.dk
Country
Europe
ProdList
6685
Advantage
47
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View Lastest Price from Sofalcone manufacturers

Sinoway Industrial co., ltd.
Product
Sofalcone 64506-49-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-05-20
Hebei Shengyuan Jinlong Import and Export Co. LTD
Product
Sofalcone 64506-49-6
Price
US $100.00-50.00/kg
Min. Order
1kg
Purity
99
Supply Ability
Monthly supply of 1 ton
Release date
2022-10-28
Handan Tongyi New Material Technology Co., Ltd
Product
Sofalcone 64506-49-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99
Supply Ability
300kg/month
Release date
2021-03-10

64506-49-6, SofalconeRelated Search:


  • {5-[(3-methyl-2-butenyl)oxy]-2-{p-[(3-methyl-2-butenyl)oxy]cinnamoyl}phenoxy}acetic acid
  • SOFALCONE
  • SOFALCONE(2'-ETHOXYCARBONYLMETHOXY-4'-(3-METHYL-2-BUTENYL-OXY)ACETOPHENONE)
  • SOFALCONE JP
  • SOFALCONE MICROPOWDER
  • [4,4'-Bis(3-methyl-2-butenyloxy)chalcon-2'-yloxy]acetic acid
  • [5-[(3-Methyl-2-butenyl)oxy]-2-[3-[4-[(3-methyl-2-butenyl)oxy]phenyl]-1-oxo-2-propenyl]phenoxy]acetic acid
  • 2-[5-[(3-Methyl-2-buten-1-yl)oxy]-2-[3-[4-[(3-Methyl-2-buten-1-yl)oxy]phenyl]-1-oxo-2-propen-1-yl]phenoxy]acetic Acid
  • Mr. Method ketone
  • 2-[5-(3-methylbut-2-enoxy)-2-[(E)-3-[4-(3-methylbut-2-enoxy)phenyl]-1-oxoprop-2-enyl]phenoxy]acetic acid
  • 2’-carboxymethoxy-4,4’-bis(3-methyl-2-butenyloxy)chalcone
  • aceticacid,(5((3-methyl-2-butenyl)oxy)-2-(3-(4-((3-methyl-2-butenyl)oxy)pheny
  • isoprenylchalcone
  • l)-1-oxo-2-propenyl)phenoxy)-
  • solon
  • su88
  • Acetic acid, 2-[5-[(3-methyl-2-buten-1-yl)oxy]-2-[3-[4-[(3-methyl-2-buten-1-yl)oxy]phenyl]-1-oxo-2-propen-1-yl]phenoxy]-
  • Sofalcone USP/EP/BP
  • 2-(5-((3-Methylbut-2-en-1-yl)oxy)-2-(3-(4-((3-methylbut-2-en-1-yl)oxy)phenyl)acryloyl)phenoxy)acetic acid
  • Sofacone
  • (E)-Sofalcone
  • 64506-49-6
  • 4506-49-6
  • 506-49-6
  • C27H30O6