5-Nitro-2-furoic acid Property

Melting point:

185-189 °C (lit.)

Boiling point:

281.7°C (rough estimate)

Density 

1.8109 (rough estimate)

refractive index 

1.4798 (estimate)

storage temp. 

Sealed in dry,2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

2.06±0.10(Predicted)

color 

White to Light Yellow

Water Solubility 

Slightly soluble in water.

BRN 

139373

CAS DataBase Reference

645-12-5(CAS DataBase Reference)

NIST Chemistry Reference

5-Nitrofuran-2-carboxylic acid(645-12-5)

Safety

Hazard Codes 

Xn

Risk Statements 

68-36/37/38-40

Safety Statements 

37/39-36/37-36-22

WGK Germany 

3

RTECS 

LV2012000

HS Code 

2932.19.5100

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

5-Nitro-2-furoic acid Chemical Properties,Usage,Production

Chemical Properties

yellow crystalline powder

Uses

5-Nitro-2-furoic acid is a representative of 2-substituted 5-nitrofurans. A number of nitrofurans have been used as antibacterial, antiprotozoal, and anthelmintic drugs in humans and animals. 2-Substituted 5-nitrofurans have been used worldwide as human and veterinary medicines, food preservatives, and feed additives, and they are utilized in human medicine as antibacterial agents. Therefore, the relationship between the antibacterial effect and the mutagenicity of these compounds and their oxidized metabolites is important. Comparison of the antibacterial effects and genotoxic potencies of nitrofuran drugs and their oxidative metabolites may provide a new direction for selecting nitrofuran drugs for human use.

Uses

5-Nitro-2-furoic acid was used in the preparation of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and [1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles. The FT-IR and FT-Raman spectra of 5-Nitro-2-furoic acid has also been studied.

General Description

The FT-IR and FT-Raman spectra of 5-Nitro-2-furoic acid has been studied.

Environmental Fate

5-Nitro^-2-furoic acid is a yellow crystalline powder with molecular weight of 157.08 g mol^-1 and density of 1.72 g cm^-3. The boiling point is 332.4 ℃ and the melting point is 185.00– 189.00 ℃ at 760 mm Hg. Vapor pressure is 5.83E-05 mm Hg at 25 ℃ and enthalpy of vaporization is 60.71 kJ mol^-1. 5-Nitro^-2-furoic acid is very soluble in water. It is stable under normal temperature and pressure.

Toxicity evaluation

The toxicological properties of this compound have not been fully investigated. However, as a minimum precaution, it should be considered harmful. Precautions should be taken and procedures adopted to prevent exposure.