Methyl 2-bromonicotinate

Product Name: Methyl 2-bromonicotinate
CAS No.: 52718-95-3
Chemical Name: Methyl 2-bromonicotinate
Synonyms: methyl 2-bromonicotinate;Methyl2-Bromonicotinate>Methyl 2-bromopyridin-3-carboxylate;METHYL 2-BROMOPYRIDINE-3-CARBOXYLATE;Methyl 2-broMo-3-pyridinecarboxylate;Methyl 2-bromopyridine-3-carboxylate, 96%;2-BROMO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER;2-Bromopyridine-3-carboxylic Acid Methyl Ester;3-pyridinecarboxylic acid, 2-bromo-, methyl ester;2-BROMO-3-PYRIDINE-3-CARBOXYLIC ACID METHYL ESTER
CBNumber: CB0171764
Molecular Formula: C7H6BrNO2
Formula Weight: 216.03
MOL File: 52718-95-3.mol

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Methyl 2-bromonicotinate Property

Melting point:: 32-37°C
Boiling point:: 95-97 °C(Press: 1.4 Torr)
Density: 1.579±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: powder to lump to clear liquid
pka: -1.25±0.10(Predicted)
color: White or Colorles to Yellow to Orange
InChIKey: RAFFKXWNTXTTFO-UHFFFAOYSA-N
CAS DataBase Reference: 52718-95-3

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Safety

WGK Germany: 3
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 706892
Product name: Methyl 2-bromopyridine-3-carboxylate
Purity: 97%
Packaging: 1g
Price: $151
Updated: 2023/06/20

TCI Chemical

Product number: M2449
Product name: Methyl 2-Bromonicotinate
Packaging: 1G
Price: $87
Updated: 2025/07/31

TCI Chemical

Product number: M2449
Product name: Methyl 2-Bromonicotinate
Packaging: 5G
Price: $345
Updated: 2025/07/31

TRC

Product number: M296040
Product name: Methyl 2-Bromonicotinate
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB149419
Product name: 2-Bromo-3-pyridinecarboxylic acid methylester
Packaging: 10g
Price: $672
Updated: 2021/12/16

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Methyl 2-bromonicotinate Chemical Properties,Usage,Production

Synthesis

13070-22-9

105-34-0

52718-95-3

In a 500 mL three-necked flask equipped with a thermometer, 61 mL (0.5 mol) of N,N-diethyl-3-aminoacrylaldehyde, 50 mL of 95% ethanol, and 5.0 g of potassium bicarbonate (KHCO3) were added sequentially, followed by the slow addition of 65 mL (0.6 mol) of methyl cyanoacetate. The assembled reaction apparatus was placed in an ultrasonic apparatus. The ultrasonic radiation conditions were set to 60 °C reaction temperature, 250 W ultrasonic power and 150 KHz frequency to start the reaction. The reaction progress was monitored by thin layer chromatography (TLC) (unfolding agent: petroleum ether to dichloromethane 1:2 v/v, color developer: sublimated iodine) until N,N-diethyl-3-aminoacrolein was fully reacted. Subsequently, hydrogen bromide (HBr) gas was passed into the reaction system, and the reaction was maintained under the above ultrasonic radiation conditions for about 35 minutes and the reaction was tracked to completion by high performance liquid chromatography (HPLC). At the end of the reaction, the pH of the reaction solution was adjusted to 5-6 with 10% potassium hydroxide solution and left to stratify. The aqueous phase was extracted with ethyl acetate (20 mL x 3) and the organic phases were combined. The organic phase was washed with 10 mL of deionized water and dried over anhydrous sodium sulfate. The desiccant was removed by filtration, and the filtrate was concentrated under reduced pressure to give a light brown liquid methyl 2-bromonicotinate (97.7 g) in 90.5% yield.

References

[1] Patent: CN104945317, 2018, B. Location in patent: Paragraph 0065; 0067; 0068

Methyl 2-bromonicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl 2-bromonicotinate manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Methyl 2-Bromonicotinate 52718-95-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 2-Bromo-3-pyridinecarboxylic acid methyl ester 52718-95-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2019-05-24

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