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2-Amino-3-chloropyridine

Application
Product Name
2-Amino-3-chloropyridine
CAS No.
39620-04-7
Chemical Name
2-Amino-3-chloropyridine
Synonyms
AURORA 15088;IFLAB-BB F3099-7175;OTAVA-BB BB7110951381;Pyridinamine, 3-chloro;3-Choro-2-pyridinamine;2-AMino-3-chloropyridi;Amino-3-Chloropyridine;3-CHLOROPYRIDIN-2-AMINE;3-Chloro-2-pyridinamine;3-CHLOROPYPRIDIN-2-AMINE
CBNumber
CB0185482
Molecular Formula
C5H5ClN2
Formula Weight
128.56
MOL File
39620-04-7.mol
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2-Amino-3-chloropyridine Property

Melting point:
59-62℃
Boiling point:
207.0±20.0 °C(Predicted)
Density 
1.326±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
powder to crystal
pka
4.14±0.36(Predicted)
color 
White to Orange to Green
InChI
InChI=1S/C5H5ClN2/c6-4-2-1-3-8-5(4)7/h1-3H,(H2,7,8)
InChIKey
RZJPBQGRCNJYBU-UHFFFAOYSA-N
SMILES
C1(N)=NC=CC=C1Cl
CAS DataBase Reference
39620-04-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-41-37/38-22-20/21/22
Safety Statements 
26-36/37/39-39-36/37-24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
734691
Product name
2-Amino-3-chloropyridine
Purity
97%
Packaging
1g
Price
$22.1
Updated
2025/07/31
TCI Chemical
Product number
A2497
Product name
2-Amino-3-chloropyridine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$81
Updated
2025/07/31
TRC
Product number
A576870
Product name
2-Amino-3-chloropyridine
Packaging
500mg
Price
$60
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-5-06
Product name
3-Chloropyridin-2-amine
Purity
95%
Packaging
1g
Price
$50
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-5-06
Product name
3-Chloropyridin-2-amine
Purity
95%
Packaging
250mg
Price
$35
Updated
2021/12/16
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2-Amino-3-chloropyridine Chemical Properties,Usage,Production

Application

3-Chloro-2-aminopyridine belongs to the pyridine derivatives and is an intermediate in organic synthesis and pharmaceutical chemistry. Industrially, it can be used as a dyeing agent and in the synthesis of active pharmaceutical ingredients.

Chemical Properties

Light green solid

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 24, p. 1313, 1987 DOI: 10.1002/jhet.5570240516

Synthesis

54231-32-2

39620-04-7

The general procedure for the synthesis of 3-chloro-2-aminopyridine from 3-chloro-2-nitropyridine was as follows: 3-chloro-2-nitropyridine (1.00 g, 6.31 mmol) was dissolved in methanol (10 mL), and stannic(II) chloride (5.98 g, 31.54 mmol) and concentrated hydrochloric acid (2.63 mL, 31.54 mmol) were added sequentially. The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the reaction solution was diluted with ethyl acetate and washed with 1N NaOH solution. Subsequently, the organic phase was washed with saturated NaHCO3 solution and dried with anhydrous Na2SO4. Finally, the organic phase was concentrated under reduced pressure to afford the target product 3-chloro-2-aminopyridine (510.0 mg, 63% yield). The product was characterized by 1H NMR (400 MHz, CD3CN) with chemical shifts of δ 6.80 (m, 1H), 7.60 (d, 1H), 8.12 (d, 1H).

References

[1] Patent: WO2006/44775, 2006, A2. Location in patent: Page/Page column 64
[2] Patent: US2009/22670, 2009, A1. Location in patent: Page/Page column 25

2-Amino-3-chloropyridine Preparation Products And Raw materials

Raw materials

Ammonium hydroxide 2,3-Dichloropyridine Ethyl acetate Ammonia

Preparation Products

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2-Amino-3-chloropyridine Suppliers

Americas 1 Austria 1 Canada 1 China 198 Europe 3 France 2 Germany 6 India 11 Japan 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 8 United States 38 Global 273
Synchem OHG
Tel
+49 5662 408730
Fax
+49 5662 4087320
Email
info@synchem.de
Country
Germany
ProdList
4705
Advantage
70
Toroma GmbH
Tel
--
Fax
--
Email
info@toroma.eu
Country
Germany
ProdList
195
Advantage
58
Toroma Organics Ltd
Tel
--
Fax
--
Country
Germany
ProdList
223
Advantage
58
ABCR GmbH & CO. KG
Tel
--
Fax
--
Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75
ACTIVATE SCIENTIFIC GmbH
Tel
--
Fax
--
Email
info@activate-scientific.com
Country
Germany
ProdList
2856
Advantage
61
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from 2-Amino-3-chloropyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Amino-3-chloropyridine 39620-04-7
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-04-30
Hebei Chuanghai Biotechnology Co,.LTD
Product
2-Amino-3-chloropyridine 39620-04-7
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-20
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Amino-3-chloropyridine 39620-04-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

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