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GLP-1

Product Name
GLP-1
CAS No.
87805-34-3
Chemical Name
GLP-1
Synonyms
GLP-1;GLP-1 (HUMAN);GLP-1 USP/EP/BP;Rat GLP-I(1-37);GLP-1, 5mg/vial;GATA-like protein 1;GLP-1 (1-37) (human);PREPROGLUCAGON 72-108;GLUCAGON-LIKE PEPTIDE I;Glucagon-likepeptide1(1-37)
CBNumber
CB0193173
Molecular Formula
C186H275N51O59
Formula Weight
4169.48
MOL File
Mol file
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GLP-1 Property

storage temp. 
−20°C
form 
Solid
Water Solubility 
Soluble to 5 mg/ml in water
InChIKey
UKVFVQPAANCXIL-FJVFSOETSA-N
CAS DataBase Reference
87805-34-3
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Safety

WGK Germany 
3
HS Code 
3504009000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G3265
Product name
Glucagon-Like Peptide I human
Purity
≥97% (HPLC)
Packaging
0.1mg
Price
$159
Updated
2024/03/01
Sigma-Aldrich
Product number
G3265
Product name
Glucagon-Like Peptide I human
Purity
≥97% (HPLC)
Packaging
0.5mg
Price
$540
Updated
2024/03/01
Alfa Aesar
Product number
J66108
Product name
Glucagon-Like Peptide-1, human
Packaging
0.5mg
Price
$191
Updated
2021/12/16
Alfa Aesar
Product number
J66108
Product name
Glucagon-Like Peptide-1, human
Packaging
1mg
Price
$393
Updated
2021/12/16
Tocris
Product number
1851
Product name
Glucagon-likepeptide1(1-37)(human,rat)
Packaging
1
Price
$450
Updated
2021/12/16
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GLP-1 Chemical Properties,Usage,Production

Description

GLP-1 stimulates pancreatic β cells to secrete insulin as an incretin hormone. GLP-1 also has additional actions, including suppression of glucagon secretion, inhibition of gastric motility, and promotion of satiety.

History

GLP-1 was first identified in the early 1980s, following the cloning of the proglucagon gene. The biological activity of GLP-1 was investigated initially by using the N-terminal extended forms of GLP-1(1–37 and 1–36 amide). However, these forms were devoid of biological activity. In the late 1980s, bioactive GLP-1 peptides were purified from gut extracts and were identified to be GLP1(7–37) and GLP-1(7–36)-amide. In the current literature, the unqualified designation of GLP-1 corresponds to the truncated peptides.

Uses

Glucagon-Like Peptide I (GLP1) has been used as an antigen in excess amounts for the incubation of primary antibodies, post-immunocytochemistry with positive results of paraffin-embedded pancreatic tissues of Rana temporaria.

Biosynthesis

Glucagon, GLP-1, and GLP-2 are processed from proglucagon in pancreatic α cells and intestinal L cells in a tissue-specific manner. Prohormone convertases (PCs) are responsible for the tissue-specific processing. Glucagon is liberated from pancreatic α cells by PC2, whereas GLP-1 and GLP-2 are liberated from the intestinal L cells by PC1/3. As a result, GLP-1 and GLP-2 are coreleased in a 1:1 ratio following nutrient ingestion. The secretion of GLP-1 is stimulated by nutrients such as lipids and carbohydrates. In addition, several hormones such as cholecystokinin (CCK), GIP, and somatostatin as well as numerous neuromediators regulate GLP-1 secretion.2 Insulin has been reported to inhibit GLP-1 release, indicating a feedback regulation of GLP-1 secretion.

General Description

Glucagon-Like Peptide I (GLP1) is an incretin hormone, which functions as ligand for GLP1 receptors (GLP1R). These receptors are expressed in renal and cardiovascular system, such as smooth muscle and endothelial cells.

Biochem/physiol Actions

Glucagon-Like Peptide I (GLP1) controls the metabolism of glucose, by inducing the secretion of insulin and suppressing that of glucagon. Studies in Indonesian population show that reduced levels of this protein are linked with increased susceptibility to type 2 diabetes mellitus. Plasma levels of this hormone also show significant association with systolic and diastolic blood pressure levels.

Clinical Use

GLP-1 enhances glucose-stimulated insulin release. GLP-1 agonists are resistant to degradation by DPP-4; thus these agonists are used clinically for the treatment of diabetes. DPP-4 inhibitors are also acceptable for use in diabetes patients because GLP-1 is rapidly deactivated by DPP-4.

Side effects

Common side effects of GLP-1 include: loss of appetite, nausea, vomiting, diarrhoea. Other side effects may include: dizziness, mild tachycardia or increased heart rate, infection, headache, and indigestion. Temporary mild itching and redness of the skin at the injection site may also occur. Serious and rare side effects include: pancreatitis, medullary thyroid cancer, acute (sudden) kidney injury, worsening of diabetes-related retinopathy, and severe allergic reactions. And GLP-1 agonists are recommended during pregnancy because they can cause abnormal foetal development. Seek medical attention if any serious adverse reactions occur.

Receptors

Structure and subtype
The receptor of GLP-1 (GLP1R) is a seventransmembrane GPCR that belongs to a subclass of the family B. The GLP-1 receptor was first identified by ligand binding experiments and measurements of cyclic AMP accumulation using the rat insulinoma cell line.3 The human GLP-1 receptor gene, GLP1R, is located on chromosome 6 (6p21). The GLP-1 receptor contains a large hydrophilic extracellular domain and seven hydrophobic transmembrane domains. In addition, the GLP-1 receptor has three potential N-linked glycosylation sites, and glycosylation may modulate the receptor function.
Signal transduction pathway
The GLP-1 receptor is functionally coupled to Gs. 3 Through the activation of AC, cAMP is formed and activates PKA.Ligand stimulation of the receptor alsoincreases the cytoplasmic concentration of Ca2+; this is brought through the Na+ -dependent uptake of extracellular Ca2+ and through the release of Ca2+ from intracellular Ca2+ stores. The increased cytosolic Ca2+ in conjunction with the activated PKA stimulates the translocation and exocytosis of insulin-containing secretory granules.
Agonists
Exendin-4 (subsequently renamed exenatide, the first FDA approved “incretin mimetic”), Liraglutide (a longacting DPP-4-resistant GLP-1 receptor agonist), CJC1131 (a GLP-1 analog engineered for covalent coupling to albumin), Albiglutide (originally referred to as albugon, a recombinant human albumin-GLP-1 protein), ZP10 (an exendin-4 derivative), BIM51077 (subsequently renamed taspoglutide), LY315902 (a DPP-4-resistant GLP-1 analog), LY2428757 (a pegylated GLP-1), LY2199265 (Dulaglutide, an Fc immunoglobulin fusion protein), Semaglutide (a synthetic peptide similar to GLP-1), Lixisenatide (a synthetic peptide similar to exandin-4), and Tirzepatide (LY3298176, a dual agonist of GIP and GLP-1 receptors).
Antagonists
Exendin (9–39), T-0632.

storage

Store at -20°C

Mode of action

Glucagon-like peptide-1 (GLP-1) released from gut enteroendocrine cells controls meal-related glycemic excursions through augmentation of insulin and inhibition of glucagon secretion. GLP-1 also inhibits gastric emptying and food intake, actions maximizing nutrient absorption while limiting weight gain.

Structure and conformation

GLP-1 is a 31-aa peptide hormone and is secreted from intestinal endocrine L cells in two major molecular forms, GLP-1(7–37) and GLP-1(7–36)-amide. Amidation is not always important for its biological activity, and these two molecular forms have similar biological activities. The majority of circulating GLP-1 is found to be GLP-1(7–36) amide, with lesser amounts of GLP-1 (7–37). GLP-1 shares a highly conserved alanine at position 9 with GIP and GLP-2, making these peptides ideal substrates for dipeptidyl peptidase 4 (DPP-4).
The primary structure of GLP-1 is highly conserved in most mammals, except for the platypus (11 substitutions). In the platypus and squirrel, GLP-1 has one substitution of the C-terminal glutamate.

GLP-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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GLP-1 Suppliers

SIGMA-RBI
Tel
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Fax
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Country
Switzerland
ProdList
6896
Advantage
91
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View Lastest Price from GLP-1 manufacturers

CONTIDE BIOTECH CO.,LTD
Product
GLP-1 87805-34-3
Price
US $0.00/G
Min. Order
1G
Purity
99%
Supply Ability
5kg
Release date
2024-05-11
hebei hongtan Biotechnology Co., Ltd
Product
GLP-1, 5mg/vial 87805-34-3
Price
US $60.00-40.00/box
Min. Order
1box
Purity
99.99%
Supply Ability
1000
Release date
2024-03-14
Shanghai Affida new material science and technology center
Product
GLP-1 87805-34-3
Price
US $0.00-0.00/BOX
Min. Order
1BOX
Purity
99
Supply Ability
200000 BOX
Release date
2024-05-09

87805-34-3, GLP-1Related Search:


  • HIS-ASP-GLU-PHE-GLU-ARG-HIS-ALA-GLU-GLY- THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-ARGY-GLY
  • GLUCAGON-LIKE PEPTIDE I HUMAN
  • GLUCAGON-LIKE PEPTIDE-1, HUMAN
  • GLUCAGON-LIKE PEPTIDE I
  • GLUCAGON-LIKE PEPTIDE 1 (1-37) (HUMAN)
  • GLUCAGON-LIKE PEPTIDE 1 (1-37) (HUMAN, BOVINE, GUINEA PIG, MOUSE, RAT)
  • GLUCAGON-LIKE PEPTIDE 1 (1-37) (HUMAN, BOVINE, GUINEA PIG, MOUSE, RAT) TRIFLUOROACETATE SALT
  • GLP-1
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  • GLP-1 (1-37) (HUMAN, BOVINE, GUINEA PIG, MOUSE, RAT) TRIFLUOROACETATE SALT
  • GLP-1 (HUMAN)
  • Glucagon-likepeptide1(1-37)
  • glucagon-like peptide I (1-37)
  • PREPROGLUCAGON 72-108
  • PREPROGLUCAGON (92-128) (HUMAN, BOVINE, GUINEA PIG, MOUSE, RAT) TRIFLUOROACETATE SALT
  • PROGLUCAGON (72-108) (HUMAN, BOVINE, GUINEA PIG, MOUSE, RAT) TRIFLUOROACETATE SALT
  • M.W. 4169.54 C186H275N51O59
  • HIS-ASP-GLU-PHE-GLU-ARG-HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-ARG-GLY
  • Glucagon-like peptide 1 (1-37) (human, rat)
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  • Preproglucagon (92-128) (huMan, bovine, guinea pig, Mouse, rat), Proglucagon (72-108) (huMan, bovine, guinea pig, Mouse, rat), Glucagon-Like Peptide 1 (1-37) (huMan, bovine, guinea pig, Mouse, rat)
  • GLP-1 (1-37) (human, bovine, gp, mouse, rat)
  • ANTI-GLP1 (CENTER) antibody produced in rabbit
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  • H-HIS-ASP-GLU-PHE-GLU-ARG-HIS-ALA-GLU-GLY-THR-PHE-THR-SER-ASP-VAL-SER-SER-TYR-LEU-GLU-GLY-GLN-ALA-ALA-LYS-GLU-PHE-ILE-ALA-TRP-LEU-VAL-LYS-GLY-ARG-GLY-OH
  • GLP-1 USP/EP/BP
  • Rat GLP-I(1-37)
  • GLP-1, 5mg/vial
  • GLP-1 (1-37) (human)
  • 87805-34-3
  • C186H275N51O59
  • Cytokines, Growth Factors and Hormones
  • Hormones
  • Other Protein/Peptide Hormones
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Glucagon receptor and related
  • hormones