ChemicalBook > CAS DataBase List > Alantolactone

Alantolactone

Product Name
Alantolactone
CAS No.
546-43-0
Chemical Name
Alantolactone
Synonyms
HELENINE;ALANTOLACETONE;Alantolactone/Helenine;4a.H-Eudesma-5,11(13)-dien-12-oic acid, 8b-hydroxy-, g-lactone;helenin;Eupatal;NSC 93131;NSC 333843;Alant camphor;ALANTOLACTONE
CBNumber
CB0194433
Molecular Formula
C15H20O2
Formula Weight
232.32
MOL File
546-43-0.mol
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Alantolactone Property

Melting point:
78-79 C
Boiling point:
275 C
alpha 
D +175° (chloroform)
Density 
1.0610 (rough estimate)
refractive index 
1.4360 (estimate)
storage temp. 
-20°C
solubility 
DMSO: soluble15mg/mL (clear solution)
form 
powder
color 
white to beige
LogP
3.380
CAS DataBase Reference
546-43-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-43
Safety Statements 
26-36-36/37-24/25
WGK Germany 
3
HS Code 
29322090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0415
Product name
Alantolactone
Purity
≥98% (HPLC)
Packaging
5mg
Price
$67.8
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0415
Product name
Alantolactone
Purity
≥98% (HPLC)
Packaging
25mg
Price
$441
Updated
2024/03/01
Sigma-Aldrich
Product number
PHL89156
Product name
Alantolactone
Purity
phyproof? Reference Substance
Packaging
10MG
Price
$430
Updated
2024/03/01
Cayman Chemical
Product number
29762
Product name
Alantolactone
Packaging
5mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
29762
Product name
Alantolactone
Packaging
10mg
Price
$116
Updated
2024/03/01
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Alantolactone Chemical Properties,Usage,Production

Description

The allergen eudesmanolide sesquiterpene lactone was isolated from elecampane (Inula helenium L.). With dehydrocostuslactone and costunolide, it is a component of the (sesquiterpene) lactone-mix, used to detect sensitization to Compositae.

Chemical Properties

Crystalline powder

Uses

anthelmintic, antibacterial, antineoplastic

Uses

Alantolactone has been used:

  • in cell viability assay
  • to examine the percentage of multicentrosomal mitosis in low and high passage human embryonic stem cells (hESC)
  • in assessment of degranulation

Uses

Alantolactone is sesquiterpene lactone that possesses anti-inflammatory property. Alantolactone have been studied to be developed as a novel agent against human liver cancer.

Definition

ChEBI: A sesquiterpene lactone that is 3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2-one bearing two methyl substituents at positions 5 and 8a as well as a methylidene substituent at position 3.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biochem/physiol Actions

Alantolactone is a sesquiterpene lactone disrupts the Cripto-1/ActRII complexes, resulting in an induction of activin/SMAD3 signaling. Alantolactone inhibits proliferation in cancer cells with no affect on normal cells.

Contact allergens

The allergen eudesmanolide sesquiterpene lactone was isolated from elecampane (Inula helenium L.). With dehydrocostuslactone and costunolide, it is a component of the (sesquiterpene) lactone mix used to detect sensitization to Compositae-Asteraceae.

storage

Store at -20°C

Alantolactone Preparation Products And Raw materials

Raw materials

Preparation Products

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Alantolactone Suppliers

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View Lastest Price from Alantolactone manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
Alantolactone 546-43-0
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000ton
Release date
2023-08-21
R&D Scientific Inc.
Product
Alantolactone 546-43-0
Price
US $580.00/g
Min. Order
1g
Purity
97
Supply Ability
500 Kg
Release date
2024-03-31
Anhui Ruihan Technology Co., Ltd
Product
Alantolactone 546-43-0
Price
US $50.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10000tons
Release date
2023-08-22

546-43-0, AlantolactoneRelated Search:

ε-Caprolactone N,N-Dimethylacetamide ETHANE Dimethyl sebacate Dimethyl sulfate Dimethyl ether Dimethyl fumarate CHLOROPHOSPHONAZO III Dimethyl carbonate N,N-Dimethylformamide Dacthal Hyaluronic acid Dimethyl sulfoxide Dimethyl sulfone Ethyl 2-(Chlorosulfonyl)acetate Dichlorodimethylsilane Dimethyl sulfide Folic acid

  • HELENINE
  • 8b-hydroxy-4ah-eudesm-5-en-12-oic acid
  • ALLANTOLACTONE
  • ALANTOLACETONE
  • ALANTOLACTONE
  • [3ar-(3aa,5b,8ab,9aa)]-3a,5,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylenenaphtho-[2,3-b]furan-2(3h)-one
  • [3aR-(3aalpha,5beta,8abeta,9aalpha)]-3a,5,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylenenaphtho[2,3-b]furan-2(3H)-one
  • Alantolactone (Helenin)
  • helenin
  • 4αH-Eudesma-5,11(13)-dien-12-oic acid, 8β-hydroxy-, γ-lactone (8CI)
  • Alant camphor
  • Alantolactone (6CI)
  • Elecampane camphor
  • Eupatal
  • Helenin (7CI)
  • Inula camphor
  • Naphtho[2,3-b]furan-2(3H)-one, 3a,5,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylene-, (3aR,5S,8aR,9aR)-
  • Naphtho[2,3-b]furan-2(3H)-one, 3a,5,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylene-, [3aR-(3aα,5β,8aβ,9aα)]-
  • NSC 93131
  • 8b-hydroxy-4aH-eudesm-s-en-12-oic acid
  • Naphtho[2,3-b]furan-2(3H)-one,3a,5,6,7,8,8a,9,9a-
  • octahydro-5,8a-dimethyl-3-methylene-,(3aR,5S,8aR,9aR)-
  • 4a.H-Eudesma-5,11(13)-dien-12-oic acid, 8b-hydroxy-, g-lactone
  • (3aR)-3a,5,6,7,8,8a,9,9aα-Octahydro-5β,8aβ-dimethyl-3-methylenenaphtho[2,3-b]furan-2(3H)-one
  • (3aR)-3aα,5,6,7,8,8a,9,9aα-Octahydro-5β,8aβ-dimethyl-3-methylenenaphtho[2,3-b]furan-2(3H)-one
  • ALANTOLACTONE(RG)
  • Alantolactone/Helenine
  • Alantic anhydride
  • NSC 333843
  • 3aR,5S,8aR,9aR)-3a,5,6,7,8,8a,9,9a-Octahydro-5,8a-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one
  • Alantolactone, 98%, from Inula helenium L.
  • (3aR,5S,8aR,9aR)-5,8a-Dimethyl-3-methylene-3,3a,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2(5H)-one
  • Alantolactone USP/EP/BP
  • Alantolactone Inula camphor
  • 3aR-(3a?,5?,8a?,9a?)]-3a,5,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylenenaphtho[2,3-b]furan-2(3H)-one
  • (+)-Alantolactone
  • hymenolactone
  • 546-43-0
  • Inhibitors
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Alkaloids
  • chiral