ChemicalBook > CAS DataBase List > Methyl 2-aminothiophene-3-carboxylate
Methyl 2-aminothiophene-3-carboxylate
- Product Name
- Methyl 2-aminothiophene-3-carboxylate
- CAS No.
- 4651-81-4
- Chemical Name
- Methyl 2-aminothiophene-3-carboxylate
- Synonyms
- METHYL 2-AMINO-3-THIOPHENECARBOXYLATE;AKOS 90546;METHYL 2-A;AKOS B014692;BUTTPARK 46\18-81;ART-CHEM-BB B014692;Methyl-2-amino-3-thenoat;methyl 2-amino-3-thenoate;Methyl 2-aMinothiophene-3-carbo; 2-Amino-3-carbomethoxythiophene
- CBNumber
- CB0202552
- Molecular Formula
- C6H7NO2S
- Formula Weight
- 157.19
- MOL File
- 4651-81-4.mol
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Methyl 2-aminothiophene-3-carboxylate Property
- Melting point:
- 76-81 °C (lit.)
- Boiling point:
- 259.5±20.0 °C(Predicted)
- Density
- 1.319±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- pka
- 0.10±0.10(Predicted)
- color
- Beige
- InChI
- InChI=1S/C6H7NO2S/c1-9-6(8)4-2-3-10-5(4)7/h2-3H,7H2,1H3
- InChIKey
- DGGJQLCAYQCPDD-UHFFFAOYSA-N
- SMILES
- C1(N)SC=CC=1C(OC)=O
- CAS DataBase Reference
- 4651-81-4(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 563080
- Product name
- Methyl 2-aminothiophene-3-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $26
- Updated
- 2023/06/20
TCI Chemical
- Product number
- M1697
- Product name
- Methyl 2-Aminothiophene-3-carboxylate
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $81
- Updated
- 2025/07/31
TCI Chemical
- Product number
- M1697
- Product name
- Methyl 2-Aminothiophene-3-carboxylate
- Purity
- min. 98.0 %
- Packaging
- 25G
- Price
- $243
- Updated
- 2025/07/31
TRC
- Product number
- M328648
- Product name
- Methyl 2-aminothiophene-3-carboxylate
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- CHM0030495
- Product name
- METHYL 2-AMINOTHIOPHENE-3-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 100G
- Price
- $1000
- Updated
- 2021/12/16
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Methyl 2-aminothiophene-3-carboxylate Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Uses
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.
Uses
Methyl 2-aminothiophene-3-carboxylate may be used to prepare 3-thiaisatoic anhydride via hydrolysis, followed by the reaction with phosgene.
Definition
ChEBI: Methyl 2-aminothiophene-3-carboxylate is a thiophenecarboxylic acid.
Synthesis
40018-26-6
105-34-0
4651-81-4
To two 20 mL microwave reaction tubes were added 1,4-dithio-2,5-diol (2.0 g, 13.1 mmol, 1.0 eq.) and methanol (10.5 mL), respectively, and the reaction tubes were sealed. Methyl cyanoacetate (2.32 mL, 26.3 mmol, 2.0 eq.), triethylamine (1.28 mL, 9.20 mmol, 0.7 eq.), and N,N-dimethylformamide (3 drops) were added sequentially through the septum to each reaction tube. The reaction mixture was placed in a microwave reactor and the reaction was heated at 50 °C for 3 min. Upon completion of the reaction, the reaction solutions in the two tubes were combined and left at room temperature to allow the product to precipitate. The precipitate was collected by filtration and washed with cold methanol to afford methyl 2-aminothiophene-3-carboxylate (16as) as a white solid (3.88 g, 24.7 mmol, 94% yield).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 8, p. 1947 - 1953
[2] Patent: WO2015/959, 2015, A1. Location in patent: Page/Page column 47
[3] Tetrahedron Letters, 2007, vol. 48, # 30, p. 5261 - 5264
[4] Tetrahedron, 2012, vol. 68, # 45, p. 9226 - 9233
[5] Patent: WO2005/63734, 2005, A2. Location in patent: Page/Page column 60-61
Methyl 2-aminothiophene-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 2-aminothiophene-3-carboxylate manufacturers
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- Methyl 2-aminothiophene-3-carboxylate 4651-81-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
Career Henan Chemical Co
- Product
- Methyl 2-aminothiophene-3-carboxylate 4651-81-4
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-20
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