Ethyl 2-aminothiophene-3-carboxylate
- Product Name
- Ethyl 2-aminothiophene-3-carboxylate
- CAS No.
- 31891-06-2
- Chemical Name
- Ethyl 2-aminothiophene-3-carboxylate
- Synonyms
- AKOS B014694;BUTTPARK 33\06-04;ART-CHEM-BB B014694;ASINEX-REAG BAS 11719538;2-AMino-3-carboethoxythiophene;2-AMINOTHIOPHENE-3-CARBOXYLATE;2-aminothiophene-3-ethyl formate;2-AMINO-3-ETHOXYCARBONYLTHIOPHENE;Ethy 2-aminothiophene-3-carboxylate;Ethyl 2-amino-3-thiophenecarboxylate
- CBNumber
- CB6315067
- Molecular Formula
- C7H9NO2S
- Formula Weight
- 171.22
- MOL File
- 31891-06-2.mol
Ethyl 2-aminothiophene-3-carboxylate Property
- Melting point:
- 42 °C
- Boiling point:
- 273.6±20.0 °C(Predicted)
- Density
- 1.262±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Chloroform, Dichloromethane
- form
- Solid
- pka
- 0.11±0.10(Predicted)
- color
- Brown
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C7H9NO2S/c1-2-10-7(9)5-3-4-11-6(5)8/h3-4H,2,8H2,1H3
- InChIKey
- MKJQYFVTEPGXIE-UHFFFAOYSA-N
- SMILES
- C1(N)SC=CC=1C(OCC)=O
- CAS DataBase Reference
- 31891-06-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- E8603-75
- Product name
- Ethyl 2-Aminothiophene-3-carboxylate
- Packaging
- 1g
- Price
- $418
- Updated
- 2021/12/16
- Product number
- E899325
- Product name
- Ethyl2-Aminothiophene-3-carboxylate
- Packaging
- 10g
- Price
- $1010
- Updated
- 2021/12/16
- Product number
- P000473716
- Product name
- Ethyl 2-aminothiophene-3-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $7
- Updated
- 2021/12/16
- Product number
- 020677
- Product name
- 2-Amino-thiophene-3-carboxylic acid ethyl ester
- Purity
- 95+%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- P000473716
- Product name
- Ethyl 2-aminothiophene-3-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $10
- Updated
- 2021/12/16
Ethyl 2-aminothiophene-3-carboxylate Chemical Properties,Usage,Production
Chemical Properties
Brown Solid
Uses
Ethyl 2-aminothiophene-3-carboxylate is used as an organic chemical synthesis intermediate.
Synthesis
40018-26-6
105-56-6
31891-06-2
The general procedure for the synthesis of ethyl 2-aminothiophene-3-carboxylate from 1,4-dithio-2,5-diol and ethyl cyanoacetate was as follows: in a 2-5 mL microwave reaction flask, ethyl cyanoacetate (0.22 mmol, 1.0 equiv.) and trifluoroethanol (2 mL) were added, and stirred for 2 min until complete dissolution. Subsequently, 1,4-dithio-2,5-diol (0.11 mmol, 0.5 eq.) was added and stirring was continued for 5 min. Next, triethylamine (0.242 mmol, 1.1 eq.) was added and the reaction mixture was stirred for another 2 minutes. The reaction flask was sealed and placed in a microwave reactor and heated at 60 °C for 390 min. After completion of the reaction, the solvent was removed by vacuum evaporation. The crude product was purified by silica gel fast column chromatography (eluent: ethyl acetate/hexane mixed solvent) to afford the target product ethyl 2-aminothiophene-3-carboxylate.
References
[1] Synthesis (Germany), 2013, vol. 45, # 1, p. 45 - 52
[2] Journal of Medicinal Chemistry, 1999, vol. 42, # 26, p. 5437 - 5447
[3] Beilstein Journal of Organic Chemistry, 2015, vol. 11, p. 875 - 883
[4] Chemical Communications, 2013, vol. 49, # 2, p. 190 - 192
[5] Archiv der Pharmazie, 2011, vol. 344, # 7, p. 459 - 465
Ethyl 2-aminothiophene-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 2-aminothiophene-3-carboxylate Suppliers
- Tel
- 13270692087
- Fax
- -
- 2488110388@qq.com
- Country
- China
- ProdList
- 32
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15838
- Advantage
- 69
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- +86-21-54098501
- Fax
- +86-21-54096319
- sales@sinch.com.cn
- Country
- China
- ProdList
- 11598
- Advantage
- 64
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
View Lastest Price from Ethyl 2-aminothiophene-3-carboxylate manufacturers
- Product
- Ethyl 2-aminothiophene-3-carboxylate 31891-06-2
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- 85.0-99.8%
- Supply Ability
- 20ton
- Release date
- 2019-12-20