1-Phenyl-1-cyclopropanecarboxylic acid
- Product Name
- 1-Phenyl-1-cyclopropanecarboxylic acid
- CAS No.
- 6120-95-2
- Chemical Name
- 1-Phenyl-1-cyclopropanecarboxylic acid
- Synonyms
- AKOS BB-9362;RARECHEM AL BO 1075;LABOTEST-BB LT00451798;1-phenyl-1-cyclopropanecarboxylate;1-phenyl-1-cycloprocarboxylic acid;1-phenylcyclopropanecarboxylic acid;1-Phenylcyclopropan-carboxylic acid;1-Phenyl-1-cyclopropanecarboxylicaci;1-Phenyl-1-cycloprppanecarboxylicacid;1-PHENYL-1-CYCLOPROPANECARBOXYLIC ACID
- CBNumber
- CB0218870
- Molecular Formula
- C10H10O2
- Formula Weight
- 162.19
- MOL File
- 6120-95-2.mol
1-Phenyl-1-cyclopropanecarboxylic acid Property
- Melting point:
- 85-87 °C (lit.)
- Boiling point:
- 248.88°C (rough estimate)
- Density
- 1.0613 (rough estimate)
- refractive index
- 1.5782 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- pka
- 4.30±0.20(Predicted)
- form
- Crystals, Crystalline Powder or Chunks
- color
- White to beige
- InChI
- InChI=1S/C10H10O2/c11-9(12)10(6-7-10)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,11,12)
- InChIKey
- IWWCCNVRNHTGLV-UHFFFAOYSA-N
- SMILES
- C1(C2=CC=CC=C2)(C(O)=O)CC1
- CAS DataBase Reference
- 6120-95-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 160075
- Product name
- 1-Phenyl-1-cyclopropanecarboxylic acid
- Purity
- 97%
- Packaging
- 10g
- Price
- $110
- Updated
- 2025/07/31
- Product number
- P2324
- Product name
- 1-Phenyl-1-cyclopropanecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $95
- Updated
- 2025/07/31
- Product number
- P2324
- Product name
- 1-Phenyl-1-cyclopropanecarboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $314
- Updated
- 2023/01/07
- Product number
- P319790
- Product name
- 1-Phenyl-1-cyclopropanecarboxylic acid
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 2621-1-90
- Product name
- 1-Phenyl-1-cyclopropanecarboxylic acid
- Packaging
- 1g
- Price
- $136
- Updated
- 2021/12/16
1-Phenyl-1-cyclopropanecarboxylic acid Chemical Properties,Usage,Production
Chemical Properties
white to beige crystals, crystalline powder
Uses
1-Phenyl-1-cyclopropanecarboxylic Acid, is an intermediate in the synthesis of pharmaceutical products including inhibitors and anticancer compounds. It is also used as the starting material in the synthesis of 2-(1-Phenylcyclopropyl)-4-oxazolecarboxylic Acid (P319785).
Synthesis
935-44-4
6120-95-2
Step (vi): synthesis of 1-phenylcyclopropanecarboxylic acid Experimental Procedure: to a solution of 1-phenylcyclopropanecarbonitrile (7 g, mmol) was added water (15 mL), acetic acid (15 mL), and concentrated sulfuric acid (15 mL) sequentially. The reaction mixture was refluxed at 110 °C overnight. After completion of the reaction, the mixture was cooled to room temperature and extracted with ethyl acetate (3 x 50 mL). The organic layers were combined, washed with saturated sodium chloride solution (2 x 50 mL) and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (230-400 mesh) with 5% ethyl acetate/hexane mixture as eluent, the target component was collected, and 1-phenylcyclopropanecarboxylic acid was obtained as a colorless solid after concentration under reduced pressure (4.35 g, 50% yield).
References
[1] Pharmaceutical Chemistry Journal, 1980, vol. 14, # 2, p. 114 - 118
[2] Khimiko-Farmatsevticheskii Zhurnal, 1980, vol. 14, # 2, p. 40 - 45
[3] European Journal of Medicinal Chemistry, 1991, vol. 26, # 2, p. 125 - 128
[4] Patent: WO2012/12410, 2012, A2. Location in patent: Page/Page column 46-47
[5] Journal of Organic Chemistry, 1959, vol. 24, p. 616,618, 619
1-Phenyl-1-cyclopropanecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Phenyl-1-cyclopropanecarboxylic acid manufacturers
- Product
- 1-Phenyl-1-cyclopropanecarboxylic acid 6120-95-2
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-18
- Product
- 1-Phenyl-1-cyclopropanecarboxylic acid 6120-95-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 1-Phenyl-1-cyclopropanecarboxylic acid 6120-95-2
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-01-02