Chloromethyl isopropyl carbonate
- Product Name
- Chloromethyl isopropyl carbonate
- CAS No.
- 35180-01-9
- Chemical Name
- Chloromethyl isopropyl carbonate
- Synonyms
- CMIC;Chloromethy Isopropyl carbonate;ALSTint-A08;Chloromethyl isoprop;Tenofovir Impurity 56;Tenofovir CMIC Impurity;Tenofovir Impurity 41 CRS;Tenofovir intermediate(CMIC);L-Propylchloromethylcarbonate;Chloromethyl isopropyl carbote
- CBNumber
- CB0223267
- Molecular Formula
- C5H9ClO3
- Formula Weight
- 152.58
- MOL File
- 35180-01-9.mol
Chloromethyl isopropyl carbonate Property
- Boiling point:
- 66 °C(Press: 16 Torr)
- Density
- 1.14
- refractive index
- 1.4110-1.4150
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly), DMSO, Ethyl Acetate (Slightly)
- form
- clear liquid
- color
- Colorless to Almost colorless
- Stability:
- Moisture sensitive
- InChI
- InChI=1S/C5H9ClO3/c1-4(2)9-5(7)8-3-6/h4H,3H2,1-2H3
- InChIKey
- JHYNXXBAHWPABC-UHFFFAOYSA-N
- SMILES
- C(OC(C)C)(=O)OCCl
- CAS DataBase Reference
- 35180-01-9(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- RIDADR
- 2924
- HazardClass
- 3/8
- PackingGroup
- Ⅲ
- HS Code
- 29189900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 1115705
- Product name
- Chloromethyl isopropyl carbonate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 100MG
- Price
- $1360
- Updated
- 2024/03/01
- Product number
- C2626
- Product name
- Chloromethyl Isopropyl Carbonate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $57
- Updated
- 2024/03/01
- Product number
- C2626
- Product name
- Chloromethyl Isopropyl Carbonate
- Purity
- >98.0%(GC)
- Packaging
- 100g
- Price
- $170
- Updated
- 2024/03/01
- Product number
- 268404
- Product name
- Chloromethyl isopropyl carbonate
- Packaging
- 5g
- Price
- $360
- Updated
- 2021/12/16
- Product number
- C369230
- Product name
- Chloromethyl Isopropyl Carbonate
- Packaging
- 100g
- Price
- $470
- Updated
- 2021/12/16
Chloromethyl isopropyl carbonate Chemical Properties,Usage,Production
Chemical Properties
Clear Colourless Liquid
Uses
Chloromethyl Isopropyl Carbonate is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor used as an anti-HIV agent.
Synthesis
At 0-5°C, a photoinitiator is added, and dimethyl carbonate and chlorine are subjected to light reaction. The reaction is stopped, and the product is distilled and separated to obtain dimethyl monochlorocarbonate. At 70-100°C, a catalyst is added, and dimethyl monochlorocarbonate and isopropanol are added to a distillation tower capable of controlling the reflux ratio. Methanol is distilled and separated under normal pressure while reacting. After the reaction is completed, excess isopropanol is distilled off under reduced pressure, and finally chloromethyl isopropyl carbonate is distilled under reduced pressure.
Chloromethyl isopropyl carbonate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Chloromethyl isopropyl carbonate manufacturers
- Product
- Chloromethyl isopropyl carbonate 35180-01-9
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 98
- Supply Ability
- 2000kg
- Release date
- 2024-05-14
- Product
- Chloromethyl Isopropyl Carbonate 35180-01-9
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-21
- Product
- Chloromethyl isopropyl carbonate 35180-01-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-09