ChemicalBook > CAS DataBase List > METHYL 3,5-DICHLOROPYRAZINE-2-CARBOXYLATE

METHYL 3,5-DICHLOROPYRAZINE-2-CARBOXYLATE

Product Name
METHYL 3,5-DICHLOROPYRAZINE-2-CARBOXYLATE
CAS No.
330786-09-9
Chemical Name
METHYL 3,5-DICHLOROPYRAZINE-2-CARBOXYLATE
Synonyms
2-Methoxycarbonyl-3,5-dichloropyrazine;METHYL 3,5-DICHLOROPYRAZINE-2-CARBOXYLATE;Methyl 3,5-dichloro-2-pyrazinecarboxylate;METHYL 3,5-DICHLOROPYRAZINE-2-CARBOXYLATE 98%;3,5-Dichloro-pyrazine-2-carboxylic acid Methyl ester;Pyrazinecarboxylic acid, 3,5-dichloro-, Methyl ester;2-Pyrazinecarboxylic acid, 3,5-dichloro-, methyl ester
CBNumber
CB02453264
Molecular Formula
C6H4Cl2N2O2
Formula Weight
207.01
MOL File
330786-09-9.mol
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METHYL 3,5-DICHLOROPYRAZINE-2-CARBOXYLATE Property

Boiling point:
269.5±35.0 °C(Predicted)
Density 
1.503±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-5.96±0.10(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C6H4Cl2N2O2/c1-12-6(11)4-5(8)10-3(7)2-9-4/h2H,1H3
InChIKey
VEDWLDKMRDJFNF-UHFFFAOYSA-N
SMILES
C1(C(OC)=O)=NC=C(Cl)N=C1Cl
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
M342903
Product name
methyl3,5-dichloropyrazine-2-carboxylate
Packaging
100mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
3770AB
Product name
Methyl3,5-dichloropyrazine-2-carboxylate
Packaging
100mg
Price
$70
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0360304
Product name
METHYL-3,5-DICHLOROPYRAZINE-2-CARBOXYLATE
Purity
95.00%
Packaging
5MG
Price
$505.4
Updated
2021/12/16
AK Scientific
Product number
3770AB
Product name
Methyl3,5-dichloropyrazine-2-carboxylate
Packaging
25g
Price
$1111
Updated
2021/12/16
Alichem
Product number
330786099
Product name
Methyl3,5-dichloropyrazine-2-carboxylate
Packaging
25g
Price
$1419.6
Updated
2021/12/16
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METHYL 3,5-DICHLOROPYRAZINE-2-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

312736-49-5

74-88-4

330786-09-9

At 23 °C, 3,5-dichloropyrazine-2-carboxylic acid (2.68 g, 13.9 mmol) and sodium bicarbonate (1.4 g, 16.6 mmol) were dissolved in DMF (20 mL), followed by addition of iodomethane (5.21 mL, 83 mmol). After completion of the reaction, the reaction mixture was diluted with 10% aqueous citric acid and extracted with EtOAc. The organic layers were combined, washed sequentially with water and brine, dried over anhydrous MgSO4 and concentrated under reduced pressure to afford the brown solid product methyl 3,5-dichloropyrazine-2-carboxylate (2.83 g, 13.6 mmol, 98% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 3.95 (s, 3H), 8.94 (s, 1H).

References

[1] Patent: WO2009/89042, 2009, A1. Location in patent: Page/Page column 113
[2] Patent: WO2018/81091, 2018, A1. Location in patent: Paragraph 0127; 0128; 0129
[3] Patent: US2014/148454, 2014, A1. Location in patent: Paragraph 0700
[4] Patent: WO2014/82739, 2014, A1. Location in patent: Page/Page column 64
[5] Patent: US2004/142930, 2004, A1

METHYL 3,5-DICHLOROPYRAZINE-2-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 3,5-DICHLOROPYRAZINE-2-CARBOXYLATE Suppliers

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330786-09-9, METHYL 3,5-DICHLOROPYRAZINE-2-CARBOXYLATERelated Search:

METHYL 3,5-DICHLOROPYRAZINE-2-CARBOXYLATE 2,6-Dichloropyrazine 5-CHLOROPYRAZINE-2-CARBALDEHYDE (5-CHLOROPYRAZIN-2-YL)METHANOL 3,5-Dichloropyrazine-2-carbaldehyde 3-CHLORO-2-PYRAZINE-CARBOXYLIC ACID METHYL 3-CHLORO-2-PYRAZINECARBOXYLATE 3-CHLORO-PYRAZINE-2-CARBALDEHYDE 5-CHLORO-PYRAZINE-2-CARBOXYLIC ACID 3,5-Dichloropyrazine-2-carboxyamide METHYL 2-CHLOROPYRIMIDINE-5-CARBOXYLATE

  • Pyrazinecarboxylic acid, 3,5-dichloro-, Methyl ester
  • METHYL 3,5-DICHLOROPYRAZINE-2-CARBOXYLATE
  • 3,5-Dichloro-pyrazine-2-carboxylic acid Methyl ester
  • 2-Methoxycarbonyl-3,5-dichloropyrazine
  • 2-Pyrazinecarboxylic acid, 3,5-dichloro-, methyl ester
  • Methyl 3,5-dichloro-2-pyrazinecarboxylate
  • METHYL 3,5-DICHLOROPYRAZINE-2-CARBOXYLATE 98%
  • 330786-09-9