ChemicalBook > CAS DataBase List > LY 334370 HYDROCHLORIDE

LY 334370 HYDROCHLORIDE

Product Name
LY 334370 HYDROCHLORIDE
CAS No.
182563-08-2
Chemical Name
LY 334370 HYDROCHLORIDE
Synonyms
Y334370;LY 334370;Y 334370 HCL;LY 334370 HCL;LY 334370 hydrochlor;LY 334370 HYDROCHLORIDE;LY334370, 10 mM in DMSO;LY334370;LY-334370;LY 334370;LY-334370 hydrochloride hydrate;4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benazmide
CBNumber
CB02459701
Molecular Formula
C21H22FN3O
Formula Weight
351.42
MOL File
182563-08-2.mol
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LY 334370 HYDROCHLORIDE Property

Boiling point:
479.1±45.0 °C(Predicted)
Density 
1.267±0.06 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
H2O: ≥5mg/mL (warmed)
form 
powder
pka
13.98±0.43(Predicted)
color 
white to tan
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0010
Product name
LY-334370 hydrochloride hydrate
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$130
Updated
2022/05/15
Sigma-Aldrich
Product number
SML0010
Product name
LY-334370 hydrochloride hydrate
Purity
≥98% (HPLC), powder
Packaging
25mg
Price
$501
Updated
2022/05/15
Tocris
Product number
3079
Product name
LY334370hydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$713
Updated
2021/12/16
Tocris
Product number
3079
Product name
LY334370hydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$194
Updated
2021/12/16
ChemScene
Product number
CS-0025021
Product name
LY334370
Purity
99.80%
Packaging
25mg
Price
$348
Updated
2021/12/16
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LY 334370 HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

LY 334370 Hydrochloride is a 5-HT1f receptor agoniist used potentially in the treatment of migranes.

Biological Activity

Selective 5-HT 1F receptor agonist (K i values are 1.87, 16.4, > 100 (IC 50 ), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC 50 ) and 3250 nM for 5-HT 1F , 5-HT 1A , 5-HT 4 , 5-HT 1E , 5-HT 1B , 5-HT 1D , 5-HT 2B , 5-HT 2A , 5-HT 7 , 5-HT 6 and 5-HT 2C receptors respectively). Displays antimigraine effects.

in vivo

Following intravenous administration of LY334370 at 3 mg/kg (n=3) or 10 mg/kg (n=6) electrical stimulation evokes an increase in dural blood vessel diameter of 135±6% and 106±11%, respectively, which is not significantly different from the respective control values. LY334370 has no effect on dural blood vessel diameter per se, since the actual dural blood vessel diameter is 43±4 arbitrary units before drug and 43±4 arbitrary units 15 min after injection of LY334370 (10 mg/kg)[1].

IC 50

5-HT1F Receptor: 1.6 nM (Ki)

LY 334370 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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LY 334370 HYDROCHLORIDE Suppliers

China 48 The Netherlands 1 United Kingdom 1 United States 10 Global 60
3B Pharmachem (Wuhan) International Co.,Ltd.
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View Lastest Price from LY 334370 HYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
LY 334370 HYDROCHLORIDE 182563-08-2
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-24

182563-08-2, LY 334370 HYDROCHLORIDERelated Search:

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  • LY 334370 HYDROCHLORIDE
  • 4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamidehydrochloride
  • 4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benazmide
  • BenzaMide, 4-fluoro-N-[3-(1-Methyl-4-piperidinyl)-1H-indol-5-yl]-
  • 4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide hydrochloride hydrate
  • LY-334370 hydrochloride hydrate
  • 4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benzamide hydrochloride
  • LY 334370
  • 4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-1H-indol-5-yl]-benzamide
  • LY 334370 HCL
  • 4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benazmide hydrochloride
  • LY334370;LY-334370;LY 334370
  • Y 334370 HCL
  • Y334370
  • LY 334370 hydrochlor
  • inhibit,Inhibitor,5-hydroxytryptamine Receptor,LY-334370,LY334370,Serotonin Receptor,5-HT Receptor
  • LY334370, 10 mM in DMSO
  • 182563-08-2
  • C21H22FN3OHCl