ChemicalBook > CAS DataBase List > ZK-261991

ZK-261991

Product Name
ZK-261991
CAS No.
886563-25-3
Chemical Name
ZK-261991
Synonyms
ZK-991;ZK 991;ZK-261991;ZK261991(ZK991);ZK 261991,ZK261991;ZK261991;ZK-261991;ZK 261991;ZK-991;ZK 991;Benzamide, 2-[[[2-[[(dimethylamino)carbonyl]amino]-4-pyridinyl]methyl]amino]-N-(2-methyl-2H-indazol-6-yl)-
CBNumber
CB02628541
Molecular Formula
C24H25N7O2
Formula Weight
443.5
MOL File
886563-25-3.mol
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ZK-261991 Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
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Hazard and Precautionary Statements (GHS)

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ZK-261991 Chemical Properties,Usage,Production

Uses

ZK-261991 is an orally active VEGFR tyrosine kinase inhibitor with an IC50 of 5 nM for VEGFR2.

in vivo

ZK991 results in a significantly reduced recruitment of CD11b+ and LYVE-1+ cells into the murine cornea. ZK991 significantly improves the graft survival rate after corneal transplantation[1].

IC 50

VEGFR2: 5 nM (IC50)

References

[1] Deniz Hos, et al. Inflammatory Corneal (Lymph)angiogenesis Is Blocked by VEGFR-Tyrosine Kinase Inhibitor ZK 261991, Resulting in Improved Graft Survival after Corneal Transplantation. Investigative Ophthalmology & Visual Science May 2008, Vol.49, 1836-184

ZK-261991 Preparation Products And Raw materials

Raw materials

Preparation Products

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ZK-261991 Suppliers

China 6 United States 5 USA 1 Global 12
MedChemexpress LLC
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Biosynth Biological Technology (Suzhou) Co Ltd
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Adooq Bioscience LLC
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886563-25-3, ZK-261991Related Search:

(+)-ZK 216348 ZK824859 ZK824859 ZK 158252 ZK164015 ZK756326(dihydrochloride) ZK 93426 hydrochloride ZK 159222 ZK 756326 ZK118182 isopropyl ester ZK-90055 (hydrochloride) ZK 110841 ZK 112993 FUDAEUIGIJZUAY-UMIRZPQISA-N

  • ZK-261991
  • ZK261991(ZK991)
  • ZK 991
  • ZK261991;ZK-261991;ZK 261991;ZK-991;ZK 991
  • ZK-991
  • Benzamide, 2-[[[2-[[(dimethylamino)carbonyl]amino]-4-pyridinyl]methyl]amino]-N-(2-methyl-2H-indazol-6-yl)-
  • ZK 261991,ZK261991
  • 886563-25-3