ZK-90055 (hydrochloride)
- Product Name
- ZK-90055 (hydrochloride)
- CAS No.
- 84638-81-3
- Chemical Name
- ZK-90055 (hydrochloride)
- Synonyms
- ZK-90055 (hydrochloride);ZK 90055 hydrochloride,ZK90055 hydrochloride
- CBNumber
- CB13339733
- Molecular Formula
- C16H23ClN2O4
- Formula Weight
- 342.82
- MOL File
- 84638-81-3.mol
ZK-90055 (hydrochloride) Property
- Melting point:
- 187-190 °C (decomp)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
ZK-90055 (hydrochloride) Chemical Properties,Usage,Production
Uses
ZK-90055 hydrochloride is a β2 adrenergic receptor agonist.
in vivo
Contrasting a pro-drug, a soft-drug is active per se when given locally but is rapidly inactivated when it reaches the general circulation. Thus, a long duration of action at a minimum of systemic side effects may be achieved after inhalation of a h2-agonist designed in this way. One such example is ZK-90055, an indol derivative with a hydrolysable ester bond on the ring system. The development of ZK-90055 is stopped before clinical trials are commenced[2].
References
[1] Waldeck B, et al. beta-Adrenoceptor agonists after terbutaline. Pharmacol Toxicol. 1995;77 Suppl 3:25-9. DOI:10.1111/j.1600-0773.1995.tb01937.x
[2] Waldeck B, et al. Beta-adrenoceptor agonists and asthma--100 years of development. Eur J Pharmacol. 2002 Jun 7;445(1-2):1-12. DOI:10.1016/s0014-2999(02)01728-4
ZK-90055 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
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