ZK756326(dihydrochloride)

Product Name: ZK756326(dihydrochloride)
CAS No.: 1780259-94-0
Chemical Name: ZK756326(dihydrochloride)
Synonyms: ZK 756326 (hydrochloride);ZK756326(dihydrochloride);ZK 756326, non-peptide CCR8 chemokine receptor agonist
CBNumber: CB63356182
Molecular Formula: C21H29ClN2O3
Formula Weight: 392.92
MOL File: 1780259-94-0.mol

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ZK756326(dihydrochloride) Property

storage temp.: Store at -20°C
solubility: PBS (pH 7.2): 10 mg/ml
form: A crystalline solid
color: White to off-white
InChI: InChI=1S/C21H28N2O3.ClH/c24-14-16-25-15-13-22-9-11-23(12-10-22)18-19-5-4-8-21(17-19)26-20-6-2-1-3-7-20;/h1-8,17,24H,9-16,18H2;1H
InChIKey: GPPMZVONOXAYET-UHFFFAOYSA-N
SMILES: C(N1CCN(CCOCCO)CC1)C1C=CC=C(OC2C=CC=CC=2)C=1.Cl

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28454
Product name: ZK 756326 (hydrochloride)
Packaging: 5mg
Price: $101
Updated: 2024/03/01

Cayman Chemical

Product number: 28454
Product name: ZK 756326 (hydrochloride)
Packaging: 25mg
Price: $399
Updated: 2024/03/01

Cayman Chemical

Product number: 28454
Product name: ZK 756326 (hydrochloride)
Packaging: 10mg
Price: $182
Updated: 2024/03/01

ChemScene

Product number: CS-7558
Product name: ZK756326dihydrochloride
Purity: 98.28%
Packaging: 25mg
Price: $228
Updated: 2021/12/16

ChemScene

Product number: CS-7558
Product name: ZK756326dihydrochloride
Purity: 98.28%
Packaging: 50mg
Price: $348
Updated: 2021/12/16

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ZK756326(dihydrochloride) Chemical Properties,Usage,Production

Uses

ZK756326 dihydrochloride is a nonpeptide chemokine receptor agonist for the CC chemokine receptor CCR8.

IC 50

CCR8: 1.8 μM (IC₅₀, in U87 cells); 5-HT_2B: 4.4 μM (IC₅₀); 5-HT_1A: 5.4 μM (IC₅₀); 5-HT₆: 5.9 μM (IC₅₀); 5-HT_5A: 16 μM (IC₅₀); 5-HT_2C: 34.8 μM (IC₅₀); α_2A: <20 μM (IC₅₀)

References

[1] Haskell CA, et al. Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8. Mol Pharmacol. 2006 Jan;69(1):309-16. DOI:10.1124/mol.105.014779

ZK756326(dihydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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ZK756326(dihydrochloride) Suppliers

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ZK756326(dihydrochloride)

ZK 756326 (hydrochloride)

ZK 756326, non-peptide CCR8 chemokine receptor agonist

1780259-94-0