ZK824859
- Product Name
- ZK824859
- CAS No.
- 2271122-53-1
- Chemical Name
- ZK824859
- Synonyms
- ZK824859,ZK-824859;(R)-2-((6-((3'-(Aminomethyl)-5-methyl-[1,1'-biphenyl]-3-yl)oxy)-3,5-difluoropyridin-2-yl)oxy)butanoic acid;Butanoic acid, 2-[[6-[[3'-(aminomethyl)-5-methyl[1,1'-biphenyl]-3-yl]oxy]-3,5-difluoro-2-pyridinyl]oxy]-, (2R)-
- CBNumber
- CB74845073
- Molecular Formula
- C23H22F2N2O4
- Formula Weight
- 428.43
- MOL File
- 2271122-53-1.mol
ZK824859 Property
- Boiling point:
- 542.7±50.0 °C(Predicted)
- Density
- 1.291±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 2.62±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A983398
- Product name
- (R)-2-((6-((3'-(Aminomethyl)-5-methyl-[1,1'-biphenyl]-3-yl)oxy)-3,5-difluoropyridin-2-yl)oxy)butanoicacid
- Purity
- 98%
- Packaging
- 5mg
- Price
- $52
- Updated
- 2021/12/16
- Product number
- A983398
- Product name
- (R)-2-((6-((3'-(Aminomethyl)-5-methyl-[1,1'-biphenyl]-3-yl)oxy)-3,5-difluoropyridin-2-yl)oxy)butanoicacid
- Purity
- 98%
- Packaging
- 10mg
- Price
- $88
- Updated
- 2021/12/16
- Product number
- A983398
- Product name
- (R)-2-((6-((3'-(Aminomethyl)-5-methyl-[1,1'-biphenyl]-3-yl)oxy)-3,5-difluoropyridin-2-yl)oxy)butanoicacid
- Purity
- 98%
- Packaging
- 50mg
- Price
- $193
- Updated
- 2021/12/16
- Product number
- CSN23689
- Product name
- ZK824859
- Packaging
- 50mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- A983398
- Product name
- (R)-2-((6-((3'-(Aminomethyl)-5-methyl-[1,1'-biphenyl]-3-yl)oxy)-3,5-difluoropyridin-2-yl)oxy)butanoicacid
- Purity
- 98%
- Packaging
- 100mg
- Price
- $308
- Updated
- 2021/12/16
ZK824859 Chemical Properties,Usage,Production
Uses
ZK824859 is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79?nM, 1580?nM and 1330?nM for human uPA, tPA, and plasmin, respectively[1].
in vivo
ZK824859 (50, 25 and 10?mg/kg; b.i.d.; 25 days) is used in a chronic mouse EAE model. ZK 824859 completely prevents the development of disease. However, two lower doses (25 and 10?mg/kg) have no effect on clinical scores[1].
| Animal Model: | Female SJL mice with chronic mouse EAE model[1] |
| Dosage: | 50, 25 and 10?mg/kg |
| Administration: | B.i.d.; 25 days |
| Result: | Prevented the development of disease at 50?mg/kg completely. However, 25 and 10?mg/kg had no effect on clinical scores. |
References
[1] Islam I, et al. Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375. DOI:10.1016/j.bmcl.2018.09.001
ZK824859 Preparation Products And Raw materials
Raw materials
Preparation Products
ZK824859 Suppliers
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