ZK118182 isopropyl ester

Product Name: ZK118182 isopropyl ester
CAS No.: 154927-31-8
Chemical Name: ZK118182 isopropyl ester
Synonyms: ZK118182 isopropyl ester;QLJUNFBXIBNQOL-LMJZMJOFSA-N;ZK118182 isopropyl ester Exclusive;ZK118182 isopropyl ester,ZK-118182 isopropyl ester;propan-2-yl 2-[4-[5-chloro-2-(3-cyclohexyl-3-hydroxyprop-1-enyl)-3-hydroxycyclopentyl]but-2-enoxy]acetate;Acetic acid, [[(2Z)-4-[(1R,2R,3R,5R)-5-chloro-2-[(1E,3S)-3-cyclohexyl-3-hydroxy-1-propenyl]-3-hydroxycyclopentyl]-2-butenyl]oxy]-, 1-methylethyl ester (9CI)
CBNumber: CB22592893
Molecular Formula: C23H37ClO5
Formula Weight: 428.99
MOL File: 154927-31-8.mol

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ZK118182 isopropyl ester Property

Boiling point:: 553.1±50.0 °C(Predicted)
Density: 1.14±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 3 mg/ml; DMSO: 2 mg/ml; Ethanol: 12.5 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
pka: 14.22±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13673
Product name: ZK118182 isopropyl ester
Purity: ≥98%
Packaging: 100μg
Price: $208
Updated: 2024/03/01

Cayman Chemical

Product number: 13673
Product name: ZK118182 isopropyl ester
Purity: ≥98%
Packaging: 500μg
Price: $925
Updated: 2024/03/01

TRC

Product number: Z485905
Product name: ZK118182isopropylester
Packaging: 250μg
Price: $450
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0068932
Product name: ((4-(5R-CHLORO-2Z-(3R-CYCLOHEXYL-3S-HYDROXY-1R-PROPENYL)-3S-HYDROXYCYCLOPENTYL)-2R-BUTENYL)OXY)-ACETIC ACID-1E-METHYLETHYL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $499.16
Updated: 2021/12/16

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ZK118182 isopropyl ester Chemical Properties,Usage,Production

Description

Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins (PGs) such as PGF_2α and PGD₂, have been shown to reduce IOP. ZK118182 is a PG analog that has potent DP-agonist activity (EC₅₀ = 16.5 nM) and a high nanomolar affinity for the DP receptor (K_i = 74 nM). ZK118182 isopropyl ester is a prodrug formulation of ZK118182 designed to enhance corneal absorption. At 0.03 μg, ZK118182 isopropyl ester has been shown to lower monkey and rabbit IOP 46% and 20%, respectively, two hours after dosing, demonstrating a much more potent effect compared to the free acid.

ZK118182 isopropyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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ZK118182 isopropyl ester Suppliers

China 14 United States 5 Global 19

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ZK118182 isopropyl ester

QLJUNFBXIBNQOL-LMJZMJOFSA-N

ZK118182 isopropyl ester Exclusive

propan-2-yl 2-[4-[5-chloro-2-(3-cyclohexyl-3-hydroxyprop-1-enyl)-3-hydroxycyclopentyl]but-2-enoxy]acetate

Acetic acid, [[(2Z)-4-[(1R,2R,3R,5R)-5-chloro-2-[(1E,3S)-3-cyclohexyl-3-hydroxy-1-propenyl]-3-hydroxycyclopentyl]-2-butenyl]oxy]-, 1-methylethyl ester (9CI)

ZK118182 isopropyl ester,ZK-118182 isopropyl ester

154927-31-8

C23H37ClO5