ChemicalBook > CAS DataBase List > ZK824859

ZK824859

Product Name
ZK824859
CAS No.
2254001-81-3
Chemical Name
ZK824859
Synonyms
CS-2839;ZK824859;ZK824190;ZK824190, 10 mM in DMSO;ZK824859;ZK-824859;ZK 824859;2254001-81-3;(R)-2-((6-((3'-(Aminomethyl)-biphenyl-3-yloxy))-3,5-difluoropyridin-2-yloxy))butanoic acid;2-[6-[3-[3-(Aminomethyl)phenyl]-5-methylphenoxy]-3,5-difluoropyridin-2-yl]oxybutanoic acid;(R)-2-((6-((3'-(aminomethyl)-[1,1'-biphenyl]-3-yl)oxy)-3,5-difluoropyridin-2-yl)oxy)butanoic acid;Butanoic acid, 2-[[6-[[3'-(aminomethyl)[1,1'-biphenyl]-3-yl]oxy]-3,5-difluoro-2-pyridinyl]oxy]-, (2R)-;Inhibitor,Serine endopeptidases,protease,multiple sclerosis,plasminogen,Urokinase,Plasminogen activator inhibitor-1,Serine,Serine proteases,Ser/Thr Protease,ZK-824190,uPA,Threonine proteases,ZK824190,inhibit,ZK 824190,PAI-1
CBNumber
CB84668701
Molecular Formula
C22H20F2N2O4
Formula Weight
414.4
MOL File
2254001-81-3.mol
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ZK824859 Property

solubility 
DMSO: Soluble
Methanol: Soluble
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biorbyt Ltd
Product number
orb573175
Product name
ZK824859
Purity
>98%
Packaging
100mg
Price
$1431.4
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573289
Product name
ZK824859
Purity
>98%
Packaging
100mg
Price
$2245.7
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573175
Product name
ZK824859
Purity
>98%
Packaging
250mg
Price
$2395.3
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573289
Product name
ZK824859
Purity
>98%
Packaging
250mg
Price
$4469.3
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573175
Product name
ZK824859
Purity
>98%
Packaging
1g
Price
$5210.5
Updated
2021/12/16
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ZK824859 Chemical Properties,Usage,Production

Uses

ZK824190 is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively[1].

in vivo

ZK824190 (2?mg/kg; PO) exhibits a relatively high oral availability and a moderate half time (T1/2=2.8 h)[1].

Animal Model:Rats with experimental autoimmune encephalomyelitis (EAE) model[1]
Dosage:2?mg/kg (Pharmacokinetic Analysis)
Administration:PO
Result:Oral availability F?=?55%; Cmax=?0.64?g/mL and AUC?=?2.2?h*g/mL; T1/2=2.8 h.

References

[1] Islam I, et al. Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375. DOI:10.1016/j.bmcl.2018.09.001

ZK824859 Preparation Products And Raw materials

Raw materials

Preparation Products

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ZK824859 Suppliers

China 38 United States 5 Global 43
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9119
Advantage
58
Fujian boshi pharmaceutical technology co. LTD
Tel
0595-22008920; 18120708884
Email
393612455@qq.com
Country
China
ProdList
255
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58

2254001-81-3, ZK824859Related Search:

(+)-ZK 216348 ZK824859 ZK 158252 ZK164015 ZK756326(dihydrochloride) ZK 93426 hydrochloride ZK 159222 ZK 756326 ZK118182 isopropyl ester ZK-90055 (hydrochloride) ZK 110841 ZK 112993 FUDAEUIGIJZUAY-UMIRZPQISA-N ZK-261991

  • CS-2839
  • ZK824859
  • ZK824859;ZK-824859;ZK 824859;2254001-81-3
  • ZK824190
  • Butanoic acid, 2-[[6-[[3'-(aminomethyl)[1,1'-biphenyl]-3-yl]oxy]-3,5-difluoro-2-pyridinyl]oxy]-, (2R)-
  • Inhibitor,Serine endopeptidases,protease,multiple sclerosis,plasminogen,Urokinase,Plasminogen activator inhibitor-1,Serine,Serine proteases,Ser/Thr Protease,ZK-824190,uPA,Threonine proteases,ZK824190,inhibit,ZK 824190,PAI-1
  • (R)-2-((6-((3'-(aminomethyl)-[1,1'-biphenyl]-3-yl)oxy)-3,5-difluoropyridin-2-yl)oxy)butanoic acid
  • ZK824190, 10 mM in DMSO
  • 2-[6-[3-[3-(Aminomethyl)phenyl]-5-methylphenoxy]-3,5-difluoropyridin-2-yl]oxybutanoic acid
  • (R)-2-((6-((3'-(Aminomethyl)-biphenyl-3-yloxy))-3,5-difluoropyridin-2-yloxy))butanoic acid
  • 2254001-81-3
  • C22H20F2N2O4