Ethyl 4,6-dichloro-1H-indole-2-carboxylate
- Product Name
- Ethyl 4,6-dichloro-1H-indole-2-carboxylate
- CAS No.
- 53995-82-7
- Chemical Name
- Ethyl 4,6-dichloro-1H-indole-2-carboxylate
- Synonyms
- Ethyl4,6-dichloro-1H-indole;ETHYL,4,6-DICLOROINDOLE-2-CARBOXYLATE;ETHYL 4,6-DICHLOROINDOLE-2-CARBOXYLATE;Ethyl 4,6-dichloro-1H-indol-2-carboxylate;ETHYL 4,6-DICHLORO-1H-INDOLE-2-CARBOXYLATE;ethyl pyruvate-3,5-di-chlorophenylhydrazone;Ethyl 4,6-dichloro-1H-indole-2-carboxylate 97%;4,6-DICHLOROINDOLE-2-CARBOXYLIC ACID ETHYL ESTER;4,6-DICHLORO-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER;1H-Indole-2-carboxylic acid, 4,6-dichloro-, ethyl ester
- CBNumber
- CB0273262
- Molecular Formula
- C11H9Cl2NO2
- Formula Weight
- 258.1
- MOL File
- 53995-82-7.mol
Ethyl 4,6-dichloro-1H-indole-2-carboxylate Property
- Melting point:
- 171-172
- Boiling point:
- 405.0±40.0 °C(Predicted)
- Density
- 1.432±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, protect from light
- pka
- 13.21±0.30(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 53995-82-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- E915865
- Product name
- Ethyl4,6-dichloro-1h-indole-2-carboxylate
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FD56357
- Product name
- 4,6-Dichloro-1H-indole-2-carboxylic acid ethyl ester
- Packaging
- 5G
- Price
- $75
- Updated
- 2021/12/16
- Product number
- Y9391
- Product name
- Ethyl4,6-dichloro-1H-indole-2-carboxylate
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- FD56357
- Product name
- 4,6-Dichloro-1H-indole-2-carboxylic acid ethyl ester
- Packaging
- 10g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 092922
- Product name
- Ethyl 4,6-dichloro-1H-indole-2-carboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $167
- Updated
- 2021/12/16
Ethyl 4,6-dichloro-1H-indole-2-carboxylate Chemical Properties,Usage,Production
Uses
Ethyl 4,6-dichloro-1H-indole-2-carboxylate is used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.
Synthesis
103855-01-2
53995-82-7
Step 3: Preparation of the intermediate ethyl 4,6-dichloro-1H-indole-2-carboxylate (I-ic) Ethyl 2-[2-(3,5-dichlorophenyl)hydrazin-1-ylidene]propanoate (26 g, 94.50 mmol in two batches) was reacted with polyphosphoric acid (260 g, each batch) at 110 °C with stirring for 3 hours. Upon completion of the reaction, the reaction mixture was slowly poured into crushed ice, stirred thoroughly and the precipitate was collected by filtration. The resulting solid was alkalized with saturated aqueous NaHCO3 (adjusted pH to 10) and subsequently extracted with ethyl acetate (3 x 150 mL). The organic layers were combined, washed with brine, dried over anhydrous Na2SO4 and concentrated. The crude product was purified by silica gel column chromatography using a hexane solution of 30% ethyl acetate as eluent to afford ethyl 4,6-dichloro-1H-indole-2-carboxylate (I-ic) 36 g in 73.8% yield as an off-white solid. 1H NMR (400 MHz, DMSO-d6): δ 12.46 (s, 1H), 7.46 (s, 1H), 7.30 (s, 1H), 7.12 (s, 1H), 4.36 (q, J = 7.2 Hz, 2H), 1.35 (t, J = 7.2 Hz, 3H). ESI MS: m/z 255.8 (M-H).
References
[1] Patent: WO2006/109633, 2006, A1. Location in patent: Page/Page column 182-183
[2] Organic Process Research and Development, 2000, vol. 4, # 6, p. 477 - 487
[3] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 4, p. 326 - 330
[4] Journal of Labelled Compounds and Radiopharmaceuticals, 2011, vol. 54, # 10, p. 645 - 656
[5] ACS Infectious Diseases, 2017, vol. 3, # 3, p. 225 - 236
Ethyl 4,6-dichloro-1H-indole-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 4,6-dichloro-1H-indole-2-carboxylate Suppliers
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View Lastest Price from Ethyl 4,6-dichloro-1H-indole-2-carboxylate manufacturers
- Product
- Ethyl 4,6-dichloroindole-2-carboxylate 53995-82-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- Ethyl 4,6-dichloroindole-2-carboxylate 53995-82-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-02