ChemicalBook > CAS DataBase List > EPIDERMAL GROWTH FACTOR, HUMAN

EPIDERMAL GROWTH FACTOR, HUMAN

Product Name
EPIDERMAL GROWTH FACTOR, HUMAN
CAS No.
62229-50-9
Chemical Name
EPIDERMAL GROWTH FACTOR, HUMAN
Synonyms
EGP;URG;HEGF;MUC9;RHEGF;CHIT5;OVGP1;kutrol;Mucin 9;LONG EGF
CBNumber
CB0295101
Molecular Formula
C257H381N73O83S7
Formula Weight
6045.66934
MOL File
62229-50-9.mol
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EPIDERMAL GROWTH FACTOR, HUMAN Property

storage temp. 
-20°C
form 
powder
color 
white to off-white
CAS DataBase Reference
62229-50-9
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Safety

Hazard Codes 
B
WGK Germany 
3
RTECS 
KB4518000
F 
10-21
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E4127
Product name
Epidermal Growth Factor from murine submaxillary gland
Purity
EGF, suitable for cell culture
Packaging
0.1mg
Price
$183
Updated
2024/03/01
Sigma-Aldrich
Product number
E4127
Product name
Epidermal Growth Factor from murine submaxillary gland
Purity
EGF, suitable for cell culture
Packaging
5x0.1mg
Price
$711
Updated
2024/03/01
Sigma-Aldrich
Product number
E1257
Product name
Epidermal Growth Factor from murine submaxillary gland
Purity
lyophilized powder, BioReagent, suitable for cell culture
Packaging
0.1mg
Price
$386
Updated
2024/03/01
Sigma-Aldrich
Product number
324831
Product name
EGF, Human, Recombinant, E. coli
Packaging
200μg
Price
$337
Updated
2024/03/01
Cayman Chemical
Product number
32057
Product name
EGF (human, recombinant)
Packaging
100μg
Price
$64
Updated
2024/03/01
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EPIDERMAL GROWTH FACTOR, HUMAN Chemical Properties,Usage,Production

Description

Epidermal growth factor (EGF) is a polypeptide ligand for the EGF receptor (EGFR; ). It is synthesized as a 1,217 amino acid glycosylated transmembrane precursor protein from which mature, soluble EGF is formed by proteolysis. Mature EGF is a 53-amino acid polypeptide that contains six cysteine residues, which form three intramolecular disulfide bonds essential to the biological activity of EGF. EGF is synthesized in the brain, kidney, pancreas, small intestine, pituitary gland, and submaxillary gland and is found in various bodily fluids, including saliva, cerebrospinal fluid, blood, breast milk, and prostatic fluid. Binding of EGF to the EGFR induces receptor dimerization, autophosphorylation, and intracellular signaling with roles in cell proliferation. In patients with early Parkinson’s disease and Alzheimer’s disease with amnestic mild cognitive impairment, low plasma EGF levels are predictive of future long-term cognitive decline. Plasma levels of EGF are reduced in pregnant woman infected with T. cruzi compared with uninfected pregnant controls. Exogenous application of EGF normalizes cortical GABAergic transmission and improves rotarod performance in the R6/2 transgenic mouse model of Huntington''s disease. Probiotic administration of E. coli engineered to secrete human EGF induces epithelial barrier restoration in a mouse model of intestinal ulcers. Immunization with human EGF induces an anti-EGF antibody response and increased survival in mice with EGFR-expressing tumors. Cayman''s EGF (human, recombinant) protein can be used for cell-based assay applications. This protein consists of 54 amino acids and has a calculated molecular mass of 6.3 kDa.

Uses

Epidermal Growth Factor (EGF) from murine submaxillary gland has been used as a mitogen, triggering the cell to commence mitosis, in a variety of cell lines. In tissue cultures, EGF acts to reduce or eliminate the requirement for serum and can be used in conjunction with other media additives and hormone. The working concentration for EGF is generally 0.1-10 ng/mL.

General Description

EGF (epidermal growth factor) is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells. Recombinant murine EGF is a 6kDa globular protein containing 53 amino acid residues, including 3 intramolecular disulfide-bonds.

Biochem/physiol Actions

EGF (epidermal growth factor) has been shown to inhibit gastric secretion, and to be involved in wound healing. EGF signals through a receptor known as c-erbB, which is a class I tyrosine kinase receptor. This receptor also binds with TGF (transforming growth factor)-α and VGF (vaccinia virus growth factor). EGF plays an important role in embryogenesis and cardiogenesis.

EPIDERMAL GROWTH FACTOR, HUMAN Preparation Products And Raw materials

Raw materials

Freeze-dried powder TRIS BORATE EDTA BUFFER, 10X, DNASE, RNASE AND PROTEASE FREE, PH 8.3, FOR MOLECULAR BIOLOGY

Preparation Products

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View Lastest Price from EPIDERMAL GROWTH FACTOR, HUMAN manufacturers

Wuhan Quanjinci New Material Co.,Ltd.
Product
EPIDERMAL GROWTH FACTOR, HUMAN 62229-50-9
Price
US $70.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
1000000tons
Release date
2023-10-30
Career Henan Chemical Co
Product
EPIDERMAL GROWTH FACTOR, HUMAN 62229-50-9
Price
US $8.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
10MT
Release date
2018-12-16

62229-50-9, EPIDERMAL GROWTH FACTOR, HUMANRelated Search:

Tris(2,4-pentanedionato)chroMiuM(III) Tosylmethyl isocyanide Cupric acetylacetonate Ethyl isocyanoacetate 2,4-PENTANEDIONE, SILVER DERIVATIVE Aluminum acetylacetonate METHYL ISOCYANOACETATE COBALT(II) ACETYLACETONATE Ferric acetylacetonate DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) N-BUTYLISOCYANIDE 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE SALCOMINE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Benzyl isocyanide TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) TERT-BUTYL ISOCYANIDE Epidermal Growth Factor Human Egf Human Epidermal Growth Factor

  • RHEGF
  • REC EGF (HUMAN)
  • REC EPIDERMAL GROWTH FACTOR (HUMAN)
  • RECOMBINANT HUMAN EGF
  • LONG EGF
  • ASN-SER-ASP-SER-GLU-CYS-PRO-LEU-SER-HIS-ASP-GLY-TYR-CYS-LEU-HIS-ASP-GLY-VAL-CYS-MET-TYR-ILE-GLU-ALA-LEU-ASP-LYS-TYR-ALA-CYS-ASN-CYS-VAL-VAL-GLY-TYR-ILE-GLY-GLU-ARG-CYS-GLN-TYR-ARG-ASP-LEU-LYS-TRP-TRP-GLU-LEU-ARG
  • EGF, HUMAN
  • EGP
  • EPIDERMAL GROWTH FACTOR, HUMAN, RECOMBINANT
  • EPIDERMAL GROWTH FACTOR, HUMAN
  • EPIDERMAL GROWTH FACTOR (EGF) HUMAN
  • HUMAN EGF
  • HUMAN EPIDERMAL GROWTH FACTOR
  • HUMAN URG
  • HUMAN UROGASTRONE
  • HEGF
  • antheloneu
  • urogastrone
  • Epidermal Growth Factor, Murine Submaxillary Glands, Recpt.
  • mouse epidermal growth factor (egf)
  • urogastrone from human pregnancy urine
  • LONGEGF MEDIA GRADE
  • LONG EGF, RECOMBINANT ANALOG
  • LONG(TM) EGF, MEDIA GRADE
  • EPIDERMAL GROWTH FACTOR FROM MOUSE*SUBMA XILLARY GLA
  • EPIDERMAL GROWTH FACTOR (FROM MOUSE SUBMAXILLARY GLAND) 95%
  • EPIDERMAL GROWTH FACTOR 98+%, LYOPHILIZED
  • EPIDERMAL GROWTH FACTOR 95+%
  • EPIDERMAL GROWTH FACTOR FROM RAT SUBMANDIBULAR GLANDS
  • EPIDERMAL GROWTH FACTOR HUMAN, RECOMBINANT 98+%
  • EGF, Epidermal cell growth factor
  • Epidermal Growth Factor from murine submaxillary gland
  • Anthelone
  • EGF (Recombinant Human Epidermal Growth Factor)
  • Epidemal Growth Factor Human from Mouse
  • CHIT5
  • MUC9
  • Mucin 9
  • OVGP1
  • Epidermal cell growth factor
  • Epidermal Growth Factor from murine submaxillary gland,EGF, Epidermal cell growth factor
  • EGF, Human, Recombinant, E. coli
  • Fc-tagged)
  • Soluble CD40 Ligand (human, recombinant
  • epidermalgrowthfactor(egf)
  • epidermalgrowthfactorreceptorgrade*frommouse
  • epidermalgrowthfactor-urogastrone
  • kutrol
  • uroanthelone
  • uroenterone
  • urogastron
  • uro-gastron
  • Oviductal glycoprotein
  • EGF, Murine Submaxillary Glands, Receptor Grade
  • EGF, Human, Recombinant,
  • LONG EGF human
  • URG
  • EGF from mouse