Ald-PEG5-Azide
- Product Name
- Ald-PEG5-Azide
- CAS No.
- 1446282-38-7
- Chemical Name
- Ald-PEG5-Azide
- Synonyms
- Ald-PEG5-Azide;CHO-PEG5-azide;N3-PEG5-CH2CHO;Ald-CH2-PEG5-N3;ALD-CH2-PEG5-AZIDE
- CBNumber
- CB03062300
- Molecular Formula
- C12H23N3O6
- Formula Weight
- 305.33
- MOL File
- 1446282-38-7.mol
N-Bromosuccinimide Price
- Product number
- A305280
- Product name
- Ald-PEG5-Azide
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- A305280
- Product name
- Ald-PEG5-Azide
- Packaging
- 10mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- BP-21721
- Product name
- Ald-CH2-PEG5-azide
- Purity
- 98%
- Packaging
- 100mg
- Price
- $295
- Updated
- 2021/12/16
Ald-PEG5-Azide Chemical Properties,Usage,Production
Description
Ald-CH2-PEG5-azide is a click chemistry crosslinker containing an azide group and an aldehyde group. The azide group enables PEGylation via Click Chemistry. PEG5 arm increases solubility in aqueous media. The aldehyde group reacts with amines and the N-terminal of peptides and proteins to form an imine containing a C=N double bond, which can be further reduced.
Uses
Ald-CH2-PEG5-azide is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Ald-CH2-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Biological Activity
Ald-CH2-PEG5-azide is a non-cleavable ADC linker containing 5-unit PEG that can be used to synthesize antibody drug conjugates (ADCs).
target
| Non-cleavable < span> |
IC 50
Non-cleavable Linker
References
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
Ald-PEG5-Azide Preparation Products And Raw materials
Raw materials
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