Acid-PEG3-t-butyl ester
- Product Name
- Acid-PEG3-t-butyl ester
- CAS No.
- 1807539-06-5
- Chemical Name
- Acid-PEG3-t-butyl ester
- Synonyms
- COOH-PEG3-OtBu;Acid-PEG3-C2-Boc;COOH-PEG3-COOtBu;HOOC-PEG2-COOtBu;Acid-PEG3-t-Bu Ester;Acid-PEG3-t-butyl ester;HOOCCH2CH2O-PEG2-CH2CH2COOtBu;Carboxy-PEG3-tert-butyl Ester;2,2-Dimethyl-4-oxo-3,7,10,13-tetraoxahexadecan-16-oic acid;4,7,10,14-Tetraoxahexadecanoic acid, 15,15-dimethyl-13-oxo-
- CBNumber
- CB43062292
- Molecular Formula
- C14H26O7
- Formula Weight
- 306.35
- MOL File
- 1807539-06-5.mol
Acid-PEG3-t-butyl ester Property
- Boiling point:
- 423.2±35.0 °C(Predicted)
- Density
- 1.106±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- solubility
- Soluble in Water, DMSO, DCM, DMF
- pka
- 4.28±0.10(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
- InChI
- InChI=1S/C14H26O7/c1-14(2,3)21-13(17)5-7-19-9-11-20-10-8-18-6-4-12(15)16/h4-11H2,1-3H3,(H,15,16)
- InChIKey
- VDWZJPCGUNJFEE-UHFFFAOYSA-N
- SMILES
- C(O)(=O)CCOCCOCCOCCC(=O)OC(C)(C)C
Safety
- HS Code
- 9999999999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- bp-22143
- Product name
- Acid-PEG3-t-butyl ester
- Purity
- 98%
- Packaging
- 100MG
- Price
- $150
- Updated
- 2026/05/24
- Product number
- bp-22143
- Product name
- Acid-PEG3-t-butyl ester
- Purity
- 98%
- Packaging
- 250MG
- Price
- $280
- Updated
- 2026/05/24
- Product number
- bp-22143
- Product name
- Acid-PEG3-t-butyl ester
- Purity
- 98%
- Packaging
- 500MG
- Price
- $430
- Updated
- 2026/05/24
- Product number
- bp-22143
- Product name
- Acid-PEG3-t-butyl ester
- Purity
- 98%
- Packaging
- 1G
- Price
- $750
- Updated
- 2026/05/24
- Product number
- BD-A754902
- Product name
- Acid-PEG3-C2-Boc
- Purity
- 95%
- Packaging
- 50mg
- Price
- $17
- Updated
- 2026/05/25
Acid-PEG3-t-butyl ester Chemical Properties,Usage,Production
Description
Acid-PEG3-t-butyl ester is a PEG linker containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses
Acid-PEG3-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the degradation of EGFR and inhibition of mTOR[1][2].
IC 50
PEGs; Alkyl/ether
References
[1] Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1.
[2] Christopher Semko, et al. Rapamycin analogs as mtor inhibitors. WO 2018204416 A1.
Acid-PEG3-t-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Acid-PEG3-t-butyl ester manufacturers
- Product
- COOH-PEG3-COOtBu 1807539-06-5
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-23