Acid-PEG3-t-butyl ester

Product Name: Acid-PEG3-t-butyl ester
CAS No.: 1807539-06-5
Chemical Name: Acid-PEG3-t-butyl ester
Synonyms: COOH-PEG3-OtBu;Acid-PEG3-C2-Boc;COOH-PEG3-COOtBu;Acid-PEG3-t-Bu Ester;Acid-PEG3-t-butyl ester;HOOCCH2CH2O-PEG2-CH2CH2COOtBu;Carboxy-PEG3-tert-butyl Ester;2,2-Dimethyl-4-oxo-3,7,10,13-tetraoxahexadecan-16-oic acid;4,7,10,14-Tetraoxahexadecanoic acid, 15,15-dimethyl-13-oxo-;3-[2-[2-(3-tert-butoxy-3-oxo-propoxy)ethoxy]ethoxy]propanoic acid
CBNumber: CB43062292
Molecular Formula: C14H26O7
Formula Weight: 306.35
MOL File: 1807539-06-5.mol

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Acid-PEG3-t-butyl ester Property

Boiling point:: 423.2±35.0 °C(Predicted)
Density: 1.106±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
solubility: Soluble in Water, DMSO, DCM, DMF
pka: 4.28±0.10(Predicted)
form: Liquid
color: Colorless to light yellow
InChI: InChI=1S/C14H26O7/c1-14(2,3)21-13(17)5-7-19-9-11-20-10-8-18-6-4-12(15)16/h4-11H2,1-3H3,(H,15,16)
InChIKey: VDWZJPCGUNJFEE-UHFFFAOYSA-N
SMILES: C(O)(=O)CCOCCOCCOCCC(=O)OC(C)(C)C

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Safety

HS Code: 9999999999

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-22143
Product name: Acid-PEG3-t-butylester
Purity: 95%
Packaging: 500mg
Price: $980
Updated: 2021/12/16

BroadPharm

Product number: BP-22143
Product name: Acid-PEG3-t-butylester
Purity: 95%
Packaging: 1g
Price: $1650
Updated: 2021/12/16

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Acid-PEG3-t-butyl ester Chemical Properties,Usage,Production

Description

Acid-PEG3-t-butyl ester is a PEG linker containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Acid-PEG3-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the degradation of EGFR and inhibition of mTOR[1][2].

IC 50

PEGs; Alkyl/ether

References

[1] Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1.
[2] Christopher Semko, et al. Rapamycin analogs as mtor inhibitors. WO 2018204416 A1.

Acid-PEG3-t-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Acid-PEG3-t-butyl ester Suppliers

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View Lastest Price from Acid-PEG3-t-butyl ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: COOH-PEG3-COOtBu 1807539-06-5
Price: US $0.00/g
Min. Order: 1g
Purity: >98.00%
Supply Ability: 1g
Release date: 2024-03-23

1807539-06-5, Acid-PEG3-t-butyl esterRelated Search:

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COOH-PEG3-OtBu

Acid-PEG3-t-butyl ester

COOH-PEG3-COOtBu

Acid-PEG3-C2-Boc

4,7,10,14-Tetraoxahexadecanoic acid, 15,15-dimethyl-13-oxo-

HOOCCH2CH2O-PEG2-CH2CH2COOtBu

2,2-Dimethyl-4-oxo-3,7,10,13-tetraoxahexadecan-16-oic acid

Acid-PEG3-t-Bu Ester

HOOCCH2CH2O-PEG2-CH2CH2COOtBu/4,7,10,14-Tetraoxahexadecanoic acid, 15,15-dimethyl-13-oxo-

Carboxy-PEG3-tert-butyl Ester

3-[2-[2-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]ethoxy]ethoxy]propanoic acid

3-[2-[2-(3-tert-butoxy-3-oxo-propoxy)ethoxy]ethoxy]propanoic acid

1807539-06-5

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